Effect of Intermittent Pneumatic Compression on Ulcer Healing in Subjects With Secondary Lymphedema

NCT ID: NCT01079299

Last Updated: 2012-02-10

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-12-31

Study Completion Date

2010-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a randomized, controlled, parallel group, open label, clinical trial to evaluate the effectiveness of intermittent, gradient, pneumatic compression (IPC)on the healing of venous ulcers in subjects diagnosed with chronic secondary lymphedema. Time to complete healing, healing rates, edema, wound pain, granulation tissue, and wound exudate (type and amount) will be compared between the IPC-treated group (IPC plus standard compression)and control (standard compression alone).

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Lymphedema

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

IPC plus standard compression

Group Type EXPERIMENTAL

Intermittent, gradient, pneumatic compression device

Intervention Type DEVICE

lymphedema pump provides external compression in a segmental,gradient fashion

Standard compression alone

Group Type ACTIVE_COMPARATOR

Intermittent, gradient, pneumatic compression device

Intervention Type DEVICE

lymphedema pump provides external compression in a segmental,gradient fashion

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Intermittent, gradient, pneumatic compression device

lymphedema pump provides external compression in a segmental,gradient fashion

Intervention Type DEVICE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Bio 4000 (Bio Compression Inc, Moonachie,NJ)

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Diagnosed with secondary lymphedema
* Presence of a venous ulcer that has not healed in more than 6 months
* Localized wound pain greater than 3 with VAS
* Ulcer must be on lower leg (below knee)
* Ulcer must be of venous etiology
* CVI proven by duplex studies
* Subject must have adequate arterial blood flow (ABI \> 0.70)
* Subject must be able to tolerate compression bandages
* Subject must be ambulatory
* Capable of understanding consent process

Exclusion Criteria

* Wound infection
* Ulcer of non-venous etiology
* Ulcer on toes or plantar surface of the foot
* Subject taking any medication that in the opinion of the investigator affects wound healing
* Alcohol or drug abuse
* Active deep venous thrombosis (DVT)
* Subject has a cancer diagnosis
* Diabetic with hemoglobin A1C\>12
* Arterial insufficiency ABI\<0.70
* Subject is not capable of walking (wheelchair-bound or bed-bound)
* Subject currently enrolled in another clinical trial
* Moderate to severe congestive heart failure
Minimum Eligible Age

21 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

RTS Family Foundation

UNKNOWN

Sponsor Role collaborator

New York State Department of Health

OTHER_GOV

Sponsor Role collaborator

Calvary Hospital, Bronx, NY

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Center for curative and Palliative Wound Care, Calvary Hospital

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Calvary Hospital, Center for Curative and Palliative Wound Care

The Bronx, New York, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CL-VU-0308

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.