Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2
34 participants
INTERVENTIONAL
2009-04-30
2009-11-30
Brief Summary
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* The prevalence of Demodex sp. in chronic blepharitis.
* The efficacy of the treatment of topical Tree Tea Oil in chronic blepharitis for Demodex sp.
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Detailed Description
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Under a slit lamp visualization, three lashes with cylindrical dandruff of each eyelid were epilated by fine forceps. The lashes were immersed in fluorescein dye and examined under a light microscope at a 20-times magnification. The mites were detected based on its morphological characteristics and movement.
The patients with chronic blepharitis who had Demodex were randomly divided in two groups. The treatment group was prescribed lid hygiene with Tea Tree Oil shampoo 0.25% and ointment 5% daily and Tea Tree Oil oily solution 50% once a week - produced by Ophthalmos, São Paulo. The control group used the same posology of placebo similar products.
After six weeks, all subjects underwent the initial clinical and laboratory examination. The symptoms and the quantity of mites (mites/eye) were compared before and after the treatment in both groups.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Interventions
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Tea Tree Oil
Tea Tree Oil shampoo 0.25% and ointment 5% daily and Tea Tree Oil oily solution 50% once a week for six weeks
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Pregnant woman
* Others Ocular Surface Disease (Severe Dry Eye, Lagoftalmo, Entropium, Ectropium)
18 Years
ALL
No
Sponsors
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Federal University of São Paulo
OTHER
Responsible Party
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Federal University of Sao Paulo
Principal Investigators
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Nahin Geha
Role: PRINCIPAL_INVESTIGATOR
Federal University of São Paulo
Locations
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Federal University of Sao Paulo
São Paulo, São Paulo, Brazil
Countries
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Other Identifiers
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Nahin Geha
Identifier Type: -
Identifier Source: org_study_id
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