Risk Factors and Biomarkers Associated With Recurrence After Excision of Primary Pterygium
NCT ID: NCT01068496
Last Updated: 2015-05-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
1 participants
OBSERVATIONAL
2010-03-31
2014-12-31
Brief Summary
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Detailed Description
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Slit lamp digital color photographs will be taken on primary and recurrent pterygium and pterygium will be graded in three levels of severity, based on relative transparency of pterygium tissue; grade 1 (transparent), grade 2 (intermediate), and grade 3 (opaque) to see whether the risk factors correlate to the morphology of the pterygium.
Tear samples will be collected before surgery using schirmers strip.Proteins in tear samples will be analyzed using the iTRAQ method.
The transcriptional differences in pterygium and conjunctival tissue samples will be analyzed using western blot, qPCR and immunohistochemistry assays.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Must agree to participate in this study
* Must sign informed consent form
Exclusion Criteria
* HIV/AIDS
21 Years
ALL
No
Sponsors
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Singapore Eye Research Institute
OTHER
Singapore National Eye Centre
OTHER_GOV
Responsible Party
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Louis Tong
Singapore National Eye Centre
Principal Investigators
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Samanthila Waduthantri
Role: STUDY_CHAIR
Singapore National Eye Centre
Laurence Lim, MBBS
Role: STUDY_CHAIR
Singapore National Eye Centre
Federico Luengo Gimeno
Role: STUDY_CHAIR
Singapore National Eye Centre
Jodhbir Mehta
Role: STUDY_CHAIR
Singapore National Eye Centre
Locations
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Singapore National Eye Centre
Singapore, Singapore, Singapore
Singapore National Eye Center
Singapore, , Singapore
Countries
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Other Identifiers
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R707/57/2009
Identifier Type: -
Identifier Source: org_study_id
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