A 6 Month Study of Once Daily Ciclesonide Hydrofluoroalkane (HFA) Nasal Aerosol in The Treatment of Perennial Allergic Rhinitis (PAR) in Subjects 12 Years and Older

NCT ID: NCT01067105

Last Updated: 2012-06-13

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

824 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-02-28

Study Completion Date

2010-11-30

Brief Summary

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6-month safety extension study in subjects who have completed Study 060-633 (NCT00953147). Evaluating the long-term safety of ciclesonide HFA nasal aerosol 160 μg administered once-daily in patients with Perennial Allergic Rhinitis.

Detailed Description

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This is a 6-month multi-center, open-label, long-term safety extension study in subjects who have completed Study 060-633 (NCT00953147). This study is designed to evaluate the long-term safety of ciclesonide HFA nasal aerosol 160 μg administered once-daily to male and female subjects 12 years or older diagnosed with perennial allergic rhinitis (PAR). This study was previously posted by Sepracor Inc. In October 2009, Sepracor Inc. was acquired by Dainippon Sumitomo Pharma., and in October 2010, Sepracor Inc's name was changed to Sunovion Pharmaceuticals Inc.

Conditions

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Perennial Allergic Rhinitis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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ciclesonide

ciclesonide HFA 160 μg once daily

Group Type EXPERIMENTAL

ciclesonide HFA 160 μg

Intervention Type DRUG

ciclesonide HFA 160 μg once daily

Interventions

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ciclesonide HFA 160 μg

ciclesonide HFA 160 μg once daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subject has successfully completed all visits of Study 060-633.
* Subject has given written informed consent and assent, including privacy authorization as well as adherence to concomitant medication withholding periods, prior to participation.
* Subject is male or female 12 years and older.
* Subject must be in general good health (defined as the absence of any clinically relevant abnormalities as determined by the Investigator) based on screening physical examination, clinical laboratory tests, and medical history.
* Subject, if female 65 years of age or younger, must have a negative urine pregnancy test (performed at Visit 1). Females of childbearing potential must be instructed to and agree to avoid pregnancy during the study and must use an acceptable method of birth control:

1. An oral contraceptive, an intrauterine device (IUD), implantable contraceptive, transdermal or injectable contraceptive for at least 1 month prior to entering the study with continued use throughout the study and for thirty days following study participation.
2. Barrier method of contraception, eg, condom and/or diaphragm with spermicide while participating in the study.
3. Abstinence.

Exclusion Criteria

* Female subject who is pregnant or lactating.
* History of physical findings of nasal pathology, including nasal polyps.
* Subject has any condition that, in the judgment of the investigator, would preclude the subject from completing the study.
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sumitomo Pharma America, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Allergy and Asthma Specialists Group

Huntington Beach, California, United States

Site Status

California Allergy and Asthma Medical Group

Los Angeles, California, United States

Site Status

Southern California Research

Mission Viejo, California, United States

Site Status

CHOC PSF, AMC, Division of Allergy Asthma and Immunology

Orange, California, United States

Site Status

California Allergy and Asthma Medical Group

Palmdale, California, United States

Site Status

Allergy Associates Medical Group

San Diego, California, United States

Site Status

Bensch Research Associates

Stockton, California, United States

Site Status

Asthma and Allergy Associates, PC

Colorado Springs, Colorado, United States

Site Status

Storms Clinical Research Institute

Colorado Springs, Colorado, United States

Site Status

Colorado Allergy and Asthma Centers

Denver, Colorado, United States

Site Status

DataQuest Medical Research

Lawrenceville, Georgia, United States

Site Status

Allergy and Asthma Consultants

Lilburn, Georgia, United States

Site Status

Clinical Research Atlanta

Stockbridge, Georgia, United States

Site Status

Clinical Research Atlanta

Stockbridge, Georgia, United States

Site Status

Atlanta Allergy and Asthma Clinic

Woodstock, Georgia, United States

Site Status

Clinical Research Center of Indiana

Indianapolis, Indiana, United States

Site Status

GR

Bethesda, Maryland, United States

Site Status

Northeast Medical Research Associates, Inc.

North Dartmouth, Massachusetts, United States

Site Status

Respiratory Medicine Research Institute of Michigan

Ypsilanti, Michigan, United States

Site Status

The Clinical Research Center

St Louis, Missouri, United States

Site Status

Clinical Research Group of Montana

Bozeman, Montana, United States

Site Status

Allergy and Asthma Center of NC

High Point, North Carolina, United States

Site Status

North Carolina Clinical Research

Raleigh, North Carolina, United States

Site Status

Toledo Center for Clinical Research

Sylvania, Ohio, United States

Site Status

Allergy and Ashtma Research Group

Eugene, Oregon, United States

Site Status

Baker Allergy, Asthma, and Dermatology Research Center

Lake Oswego, Oregon, United States

Site Status

Allergy Associates Research Center

Portland, Oregon, United States

Site Status

Valley Clinical Research

Bethlehem, Pennsylvania, United States

Site Status

Asthma and Allergy Research

Upland, Pennsylvania, United States

Site Status

Asthma, Nasal Disease, and Allergy Research Center of New England

Providence, Rhode Island, United States

Site Status

National Allergy, Asthma, and Urticaria Centers

Charleston, South Carolina, United States

Site Status

ISIS Clinical Research

Austin, Texas, United States

Site Status

Sirius Clinical Research

Austin, Texas, United States

Site Status

TTS Research

Boerne, Texas, United States

Site Status

Pharmaceutical Research and Consulting

Dallas, Texas, United States

Site Status

North Texas Institute for Clinical Trials

Fort Worth, Texas, United States

Site Status

Allergy and Asthma Associates

Houston, Texas, United States

Site Status

Kerrville Research Associates

Kerrville, Texas, United States

Site Status

Central Texas Health Research

New Braunfels, Texas, United States

Site Status

Western Sky Medical Research

Paso, Texas, United States

Site Status

Biogenics Research Institute

San Antonio, Texas, United States

Site Status

Southwest Allergy and Asthma Center

San Antonio, Texas, United States

Site Status

Sylvana Research

San Antonio, Texas, United States

Site Status

ASTHMA Inc.

Seattle, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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060-635

Identifier Type: -

Identifier Source: org_study_id

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