Bright Light: A Novel Treatment for Anxiety

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2007-12-31

Brief Summary

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The primary aim of this research was to examine the influence of bright light on anxiety in high-anxious young adults. In an acute exposure study, participants were randomly assigned to 45 min of either (1) bright light (3,000 lux) or (2) a placebo inactivated negative ion generator. Treatments were initiated ≤1 hr after awakening. At 10 min before and 30 min after the treatments, state anxiety, mood, and blood pressure were assessed.

Following the acute exposure study, participants performed a 5-week study. Following a a 1-week baseline, participants were randomly assigned to four weeks of daily exposure to either (1) bright light (45 min/day; 3,000 lux) or (2) placebo inactivated negative ion generator, which were initiated ≤1 hr after awakening. Before and after the experiment, clinical ratings were conducted with the Hamilton Anxiety Scale, the Hamilton Depression Scale, and the Clinical Global Impressions scale (CGI). Following baseline, and following each week of treatment, blood pressure, as well as questionnaires for state anxiety, depression, mood, sleep, and side effects were assessed.

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Detailed Description

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Conditions

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Anxiety Depression Sleep

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Baseline

1 week period, in which subjects followed usual schedule, though they were asked to maintain a fairly stable sleep schedule. The baseline period was used for comparison with the experimental intervention.

Group Type NO_INTERVENTION

No interventions assigned to this group

Experimental Intervention

Randomized exposure to the 4-week experimental treatments.

Group Type EXPERIMENTAL

Litebook Bright Light Box

Intervention Type DEVICE

Four weeks of daily exposure to bright light (3,000 lux) for 45 min/day, beginning within 60 min of arising.

Litebook inactivated negation ion generator (the placebo)

Intervention Type DEVICE

Four weeks of daily exposure to inactivated negative ion generator for 45 min/day, beginning within 60 min of arising

Interventions

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Litebook Bright Light Box

Four weeks of daily exposure to bright light (3,000 lux) for 45 min/day, beginning within 60 min of arising.

Intervention Type DEVICE

Litebook inactivated negation ion generator (the placebo)

Four weeks of daily exposure to inactivated negative ion generator for 45 min/day, beginning within 60 min of arising

Intervention Type DEVICE

Other Intervention Names

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Phototherapy Placebo

Eligibility Criteria

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Inclusion Criteria

* Having a level of trait anxiety \[Spielberger State-Trait Anxiety Inventory (Form Y1)\]{23642} that was ≥ the 75th percentile for their age (i.e., ≥ 46 and ≥ 44 for women and men, respectively)

Exclusion Criteria

* Current treatment for anxiety or depression;
* History of bipolar disorder, mania, or psychotic disorders;
* History of winter depression, which might bias towards positive response to light;
* Hypertension;
* Ophthalmic abnormalities; and
* Usual exposure to high levels of light such that the intervention would add little to usual exposure.

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes