Intrauterine Human Chorionic Gonadotrophins (hCG) and Endometrial Treg Cells
NCT ID: NCT01064219
Last Updated: 2013-11-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2010-02-28
2010-12-31
Brief Summary
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Detailed Description
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To study the effect of intrauterine injection of human chorionic gonadotrophin on the endometrial T regulatory cells (Treg cells)and the electromicroscopic endometrial characteristics.
Background:
It has been demonstrated that regulatory T cells expand during pregnancy and are present at the feto-maternal interface at very early stages in pregnancy.
Rational:
Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation.
Methods:
Intrauterine injection of 100 IU hCG will be done followed by endometrial biopsy to check for Treg cells and pinopodes.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
DOUBLE
Study Groups
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intrauterine hCG
intrauterine injection of 100 hCG followed by endometrial biopsy
human chorionic gonadotrophin
intrauterine injection of 100 IU hCG followed by endometrial biopsy .
Interventions
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human chorionic gonadotrophin
intrauterine injection of 100 IU hCG followed by endometrial biopsy .
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Ovulatory factor infertility
* Unexplained infertility
* Female age less than 39
Exclusion Criteria
* Tubal factor infertility
* Pelvic endometriosis
20 Years
38 Years
FEMALE
No
Sponsors
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The Egyptian IVF-ET Center
OTHER
Responsible Party
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Ragaa Mansour
Director, the Egyptian IVF-ET Center
Principal Investigators
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Ragaa Mansour, MD,PhD
Role: PRINCIPAL_INVESTIGATOR
The Egyptian IVF-ET Center
Locations
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Cairo University
Cairo, , Egypt
Countries
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Related Links
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Related Info
Other Identifiers
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hCG and Treg cells
Identifier Type: -
Identifier Source: org_study_id