Protocol for RCT of Posturing in Phacovitrectomy for Full Thickness Macular Hole (FTMH)

NCT ID: NCT01020760

Last Updated: 2012-04-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-09-30

Study Completion Date

2010-10-31

Brief Summary

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The purpose of this study is to determine the effect of postoperative posturing on the outcome of macular hole surgery. Current practice is divided; some individuals are advised to posture face-down for 10 days and others are advised that posturing is unnecessary. By evaluating the effect of posturing in a prospective randomised controlled trial the investigators hope to determine best practice, enabling surgeons and patients to make informed decisions regarding postoperative management.

Detailed Description

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Conditions

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Full Thickness Macular Hole

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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No posture

Patients will undergo routine phacoemulsification, pars plana vitrectomy, ILM peel and gas fluid exchange with 14% C3F8. They will be advised to avoid supine posturing for seven days after surgery, but will not be advised to posture in the face down or prone position.

Group Type NO_INTERVENTION

No interventions assigned to this group

Face down posture

Patients will undergo routine phacoemulsification, pars plana vitrectomy, ILM peel and gas fluid exchange with 14% C3F8. They will be advised to posture in the face down or prone position for 50 minutes per hour for seven days.

Group Type EXPERIMENTAL

Face down posture

Intervention Type BEHAVIORAL

Patients are requested to maintain a strict face down posture for 50 minutes out of every hour for seven days after surgery.

Interventions

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Face down posture

Patients are requested to maintain a strict face down posture for 50 minutes out of every hour for seven days after surgery.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. Patients having surgery for idiopathic full thickness macular hole
2. Able and willing to posture face-down for 10 days postoperatively
3. Agree to participate in the trial and able to give informed consent

Exclusion Criteria

1. History of visual loss suggesting a duration of macular hole greater than 12 months
2. Patients unable or unwilling to posture face-down for 10 days postoperatively
3. History of trauma that may have been causative
4. Age less than 16 years (in practice idiopathic macular hole is extremely rare in patients under 30 years).
5. Previous vitrectomy surgery
6. Additional retinal breaks occurring during surgery that necessitate post-operative posturing to prevent retinal detachment.
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NHS Greater Glasgow and Clyde

OTHER

Sponsor Role lead

Responsible Party

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David Yorston

Consultant Ophthalmologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Gartnavel General Hospital

Glasgow, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Yorston D, Siddiqui MA, Awan MA, Walker S, Bunce C, Bainbridge JW. Pilot randomised controlled trial of face-down posturing following phacovitrectomy for macular hole. Eye (Lond). 2012 Feb;26(2):267-71. doi: 10.1038/eye.2011.220. Epub 2011 Sep 23.

Reference Type RESULT
PMID: 21941363 (View on PubMed)

Other Identifiers

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Version 1

Identifier Type: -

Identifier Source: org_study_id

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