Cementless One-stage Revision of the Chronic Infected Hip Arthroplasty

NCT ID: NCT01015365

Last Updated: 2017-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-11-30

Study Completion Date

2017-11-30

Brief Summary

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The investigators hypothesise that cementless one-stage exchange revision surgery can be performed in patients with chronically infected hip replacement with substantial benefits for the patients, in terms of fast rehabilitation, low re-revision rates and good long term results.

Detailed Description

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Conditions

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Infection Hip Joint Replacement

Keywords

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Chronic infected hip arthroplasty Fast-track One-stage cementless revision

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Surgical revision

Surgical cementless One-stage revision of the chronic infected hip arthroplasty

Group Type OTHER

Cementless one-stage surgical revision

Intervention Type PROCEDURE

A Cementless one-stage surgical revision is to be performed for all included in the cohort.

Interventions

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Cementless one-stage surgical revision

A Cementless one-stage surgical revision is to be performed for all included in the cohort.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patient with clinical signs of infection for more than 4 weeks, arising from total hip arthroplasty (primary and revision), resurfacing hip arthroplasty or hemi-hip arthroplasty
* Informed oral and written consent given

Exclusion Criteria

* Life expectancy under 2 years
* Cognitive dysfunction
* Pre-operative unwillingness to receive blood
* Intravenous drug abuse
* Alcoholism
* Immunocompromised patients
* Patients receiving immunosuppressive medication
* Ongoing systemic inflammatory disease
* Poorly regulated diabetes mellitus
* Renal failure (requiring dialysis)
* Acute systemic inflammatory response syndrome with proven infection (sepsis)
* Signs of coexisting active long-term local infection (i.e. endocarditis)
* Previous two-stage revision of hip arthroplasty due to ipsilateral chronic infection (regardless of symptom free interval) or contralateral chronic infection (within the last 2 years).
* \< 6 weeks since last surgery of the affected hip
* If definition of infection is not fulfilled: infection defined as Culture positive: ≥ 3 positive intraoperative cultures (tissue biopsies a.m. Kamme-Lindberg) Culture negative: \< 3 positive intraoperative cultures (tissue biopsies a.m. Kamme-Lindberg) + Chronic fistula with history of previous or existing secretion or Positive cultures in pre-operatively joint fluid aspiration with other clinical signs of infection or Visual pus or purulent fluid during exchange procedure with clinical signs of infection
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kjeld Soballe, Prof. D.Msc.

Role: STUDY_CHAIR

Lundbeckfoundation center for fast-track hip and knee surgery

Jeppe Lange, M.D.

Role: PRINCIPAL_INVESTIGATOR

Lundbeckfoundation center for fast-track hip and knee surgery

Locations

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Orthopaedic Center, Alborg sygehus, Aarhus Universityhospital

Aalborg, , Denmark

Site Status

Orthopaedic department, Aarhus Universityhospital

Aarhus, , Denmark

Site Status

Gentofte Hospital

Hellerup, , Denmark

Site Status

Orthopaedic department, Hvidovre Hospital

Hvidovre, , Denmark

Site Status

Regionalhospital Silkeborg

Silkeborg, , Denmark

Site Status

Sønderborg Hospital

Sønderborg, , Denmark

Site Status

Vejle Hospital

Vejle, , Denmark

Site Status

Regional Hospital Viborg

Viborg, , Denmark

Site Status

Countries

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Denmark

Related Links

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http://www.fthk.dk

Webpage of the Lundbeckfoundation center for fast-track hip and knee surgery

Other Identifiers

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CORIHA

Identifier Type: -

Identifier Source: org_study_id