The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems?

NCT ID: NCT00988663

Last Updated: 2017-03-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2009-11-30

Study Completion Date

2009-11-30

Brief Summary

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The purpose of this study is to determine whether memantine will enhance the therapeutic of effect on depression and prevent memory and other cognitive problems caused by ECT.

Detailed Description

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Patients will be assigned randomly either to a treatment group or a placebo groups. All patients in both groups will be receiving standard ECT. The treatment group will receive memantine. All patients will be given a battery of cognitive tests and test of depression before ECT treatments start, after the 6th ECT treatment and after the completions of ECT. An analysis will be performed to see if memantine causes any impact on the response to ECT and prevents memory and cognitive impairment.

Conditions

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Major Depressive Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Memantine arm

Patient receiving ECT and Memantine

Group Type ACTIVE_COMPARATOR

memantine

Intervention Type DRUG

patient will receive 5mg daily for 7day then 10 mgm daily

placebo

25 patients receiving ECT will will receive placebo

Group Type PLACEBO_COMPARATOR

memantine

Intervention Type DRUG

patient will receive 5mg daily for 7day then 10 mgm daily

Placebo

Intervention Type DRUG

will give placebo that looks like memantine

Interventions

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memantine

patient will receive 5mg daily for 7day then 10 mgm daily

Intervention Type DRUG

Placebo

will give placebo that looks like memantine

Intervention Type DRUG

Other Intervention Names

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Namenda

Eligibility Criteria

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Inclusion Criteria

* Meets criteria for Major Depressive disorder

Exclusion Criteria

* Neurological disease
* Mental retardation
* Seizure disorder
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Jerrry L Lewis

OTHER

Sponsor Role lead

Responsible Party

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Jerrry L Lewis

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Jerry L Lewis, MD

Role: PRINCIPAL_INVESTIGATOR

University of Iowa Hospitals and Clinic

Locations

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University of Iowa hosptitals and clinic

Iowa City, Iowa, United States

Site Status

Countries

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United States

Other Identifiers

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Memantine ECT trial

Identifier Type: -

Identifier Source: org_study_id

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