Metabolism of Lipids in Advanced Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

12 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-10-31

Study Completion Date

2011-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The causes of failing nutrition status in advanced cancer are not well known. The way fat is moved, stored, burned or changed into other compounds may be affected and will be followed in patients using a tracer and other blood tests. The investigators hypothesize that fat loss and wasting results from low essential fatty acid availability in the body. Changes may occur in the liver that limits distribution and availability of fat to the body as an energy source or for other essential functions.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The RECHARGE Low Carbohydrate Diet Trial for Metastatic Cancer

NCT00444054

Cancer Breast Cancer Colon Cancer +3 more

COMPLETED NA

Medical Nutrition Therapy or Standard Care in Treating Patients With Lung Cancer, Pancreatic Cancer, or Stage III or Stage IV Prostate Cancer

NCT00769652

Lung Cancer Malnutrition Pancreatic Cancer +2 more

TERMINATED NA

Safety and Efficacy of ALC in Breast Cancer in Subjects With Fatigue

NCT00555841

Breast Cancer

TERMINATED PHASE2

Evaluating a Fasting-mimicking Diet in Combination With Immunotherapy in Patients With Non-small Cell Lung Cancer

NCT06671613

Stage IV NSCLC NSCLC Immunotherapy +1 more

RECRUITING NA

Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy

NCT02330926

Cachexia Neoplasms

COMPLETED PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Weight loss in cancer is the result of breakdown of fat (lipid) and muscle protein reserves. This research will explore how people with cancer use fat in their body through the use of tracers and measures in the blood. A stable isotope of hydrogen called 'deuterium' is used to trace the production of different fats by the liver. Other methods will determine how much and what types of fat are transported around the body. Body composition will be determined by CT scan and related to fat measures.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Lung Neoplasms Cachexia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Metabolism

Lung cancer patients who exhibit abnormalities in lipid measures.

Blood draws

Intervention Type OTHER

Up to 4 blood draws will be required, in the amount of about 10 mL each

Oral administration of stable isotope (deuterium)

Intervention Type BIOLOGICAL

1 mg deuterium-labeled water/kg body water (loading dose), and 0.5 mg/kg body water diluted in 1 L of normal water (maintenance dose) to be consumed over the following 16 hours

Metabolic rate testing

Intervention Type PROCEDURE

Metabolic rate testing is a painless, non-invasive test that takes about 1h. A metabolic cart is used, which detects the amount of oxygen and carbon dioxide the body uses. Patients will lie down on a bed for 30 minutes with lights dimmed and soft music to help them relax. After 30 minutes, a canopy will be placed over the patient's head and shoulders for 30 minutes for the analysis of breath samples. This test will be performed only once for this study.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Blood draws

Up to 4 blood draws will be required, in the amount of about 10 mL each

Intervention Type OTHER

Oral administration of stable isotope (deuterium)

1 mg deuterium-labeled water/kg body water (loading dose), and 0.5 mg/kg body water diluted in 1 L of normal water (maintenance dose) to be consumed over the following 16 hours

Intervention Type BIOLOGICAL

Metabolic rate testing

Metabolic rate testing is a painless, non-invasive test that takes about 1h. A metabolic cart is used, which detects the amount of oxygen and carbon dioxide the body uses. Patients will lie down on a bed for 30 minutes with lights dimmed and soft music to help them relax. After 30 minutes, a canopy will be placed over the patient's head and shoulders for 30 minutes for the analysis of breath samples. This test will be performed only once for this study.

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

C/D/N Isotopes, Deuterium Oxide, CAS No: 7789-20-0

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Low plasma phospholipids OR low plasma ratio of triglycerides to free fatty acids
* Recent weight loss
* Advanced stage lung cancer (Stage 3 or 4)

Exclusion Criteria

* Having symptoms that may affect measures of fat metabolism (nausea, vomiting, problems swallowing, etc.)
* Taking n-3 fatty acid supplements such as fish oil

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No