Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Total Enrollment
50 participants
Study Classification
OBSERVATIONAL
Study Start Date
2008-08-31
Study Completion Date
2011-09-30
Brief Summary
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The UCLA Semel Institute for Neuroscience in Los Angeles, CA, is conducting a study looking at similarities and differences in how the brain works between bipolar disorder and attention deficit hyperactivity disorder (ADHD).
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Detailed Description
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Children between the ages of 7 and 17 years old, with a diagnosis of Bipolar I, Bipolar II, or Bipolar NOS, are currently being recruited for this study looking at similarities and differences in how the brain works between bipolar disorder and attention deficit hyperactivity disorder (ADHD). The study involves a comprehensive evaluation at intake, cognitive assessment, EEG, and functional MRI, done over the course of 2 or 3 visits. This study does not provide treatment. However, with participants' consent, the assessment information can be shared with the child's clinician or psychiatrist and a letter with the results from cognitive testing can be prepared, which can be useful in school planning. Referrals for treatment can also be provided.
Conditions
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Bipolar Disorder
Study Design
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Study Time Perspective
CROSS_SECTIONAL
Eligibility Criteria
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Inclusion Criteria
* Subject suffers clinically impairing symptoms of mood lability.
* Child has resided with primary caretaker for at least 6 months.
* Caretaker speaks sufficient English to complete all study evaluations and measures.
* Child has resided with primary caretaker for at least 6 months.
* Caretaker speaks sufficient English to complete all study evaluations and measures.
Exclusion Criteria
* Lifetime history of mental retardation, autism, or primary diagnosis of psychosis.
* Subject is pregnant or nursing.
* Subject is pregnant or nursing.
Minimum Eligible Age
7 Years
Maximum Eligible Age
17 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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National Institute of Mental Health (NIMH)
NIH
Sponsor Role
collaborator
The State Family Fund
UNKNOWN
Sponsor Role
collaborator
University of California, Los Angeles
OTHER
Sponsor Role
lead
Responsible Party
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James McCracken
Chair
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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Patricia Walshaw, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of California, Los Angeles
Locations
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UCLA Semel Institute for Neuroscience and Human Behavior
Los Angeles, California, United States
Site Status
Countries
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United States
References
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Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986 Dec;51(6):1173-82. doi: 10.1037//0022-3514.51.6.1173.
Reference Type
BACKGROUND
Bearden CE, Hoffman KM, Cannon TD. The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disord. 2001 Jun;3(3):106-50; discussion 151-3. doi: 10.1034/j.1399-5618.2001.030302.x.
Reference Type
BACKGROUND
Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Arch Gen Psychiatry. 2003 Jun;60(6):601-9. doi: 10.1001/archpsyc.60.6.601.
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BACKGROUND
Carlson GA. Mania and ADHD: comorbidity or confusion. J Affect Disord. 1998 Nov;51(2):177-87. doi: 10.1016/s0165-0327(98)00179-7.
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BACKGROUND
Carlson GA. Juvenile mania versus ADHD. J Am Acad Child Adolesc Psychiatry. 1999 Apr;38(4):353-4. doi: 10.1097/00004583-199904000-00001. No abstract available.
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BACKGROUND
Casey BJ, Castellanos FX, Giedd JN, Marsh WL, Hamburger SD, Schubert AB, Vauss YC, Vaituzis AC, Dickstein DP, Sarfatti SE, Rapoport JL. Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1997 Mar;36(3):374-83. doi: 10.1097/00004583-199703000-00016.
Reference Type
BACKGROUND
Castellanos FX, Giedd JN, Eckburg P, Marsh WL, Vaituzis AC, Kaysen D, Hamburger SD, Rapoport JL. Quantitative morphology of the caudate nucleus in attention deficit hyperactivity disorder. Am J Psychiatry. 1994 Dec;151(12):1791-6. doi: 10.1176/ajp.151.12.1791.
Reference Type
BACKGROUND
Faraone SV, Biederman J, Wozniak J, Mundy E, Mennin D, O'Donnell D. Is comorbidity with ADHD a marker for juvenile-onset mania? J Am Acad Child Adolesc Psychiatry. 1997 Aug;36(8):1046-55. doi: 10.1097/00004583-199708000-00012.
Reference Type
BACKGROUND
Geller B, Luby J. Child and adolescent bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry. 1997 Sep;36(9):1168-76. doi: 10.1097/00004583-199709000-00008.
Reference Type
BACKGROUND
Geller B, Tillman R, Craney JL, Bolhofner K. Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Arch Gen Psychiatry. 2004 May;61(5):459-67. doi: 10.1001/archpsyc.61.5.459.
Reference Type
BACKGROUND
Geller B, Williams M, Zimerman B, Frazier J, Beringer L, Warner KL. Prepubertal and early adolescent bipolarity differentiate from ADHD by manic symptoms, grandiose delusions, ultra-rapid or ultradian cycling. J Affect Disord. 1998 Nov;51(2):81-91. doi: 10.1016/s0165-0327(98)00175-x.
Reference Type
BACKGROUND
Geller B, Zimerman B, Williams M, Delbello MP, Bolhofner K, Craney JL, Frazier J, Beringer L, Nickelsburg MJ. DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol. 2002 Spring;12(1):11-25. doi: 10.1089/10445460252943533.
Reference Type
BACKGROUND
Gruber SA, Rogowska J, Yurgelun-Todd DA. Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. J Affect Disord. 2004 Oct 15;82(2):191-201. doi: 10.1016/j.jad.2003.10.010.
Reference Type
BACKGROUND
Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8. doi: 10.1097/00004583-199707000-00021.
Reference Type
BACKGROUND
Kent L, Craddock N. Is there a relationship between attention deficit hyperactivity disorder and bipolar disorder? J Affect Disord. 2003 Feb;73(3):211-21. doi: 10.1016/s0165-0327(02)00092-7.
Reference Type
BACKGROUND
Kovatchev B, Cox D, Hill R, Reeve R, Robeva R, Loboschefski T. A psychophysiological marker of attention deficit/hyperactivity disorder (ADHD)--defining the EEG consistency index. Appl Psychophysiol Biofeedback. 2001 Jun;26(2):127-40. doi: 10.1023/a:1011339206875.
Reference Type
BACKGROUND
Mostofsky SH, Cooper KL, Kates WR, Denckla MB, Kaufmann WE. Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2002 Oct 15;52(8):785-94. doi: 10.1016/s0006-3223(02)01412-9.
Reference Type
BACKGROUND
National Institute of Mental Health research roundtable on prepubertal bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2001 Aug;40(8):871-8. doi: 10.1097/00004583-200108000-00007.
Reference Type
BACKGROUND
Quraishi S, Frangou S. Neuropsychology of bipolar disorder: a review. J Affect Disord. 2002 Dec;72(3):209-26. doi: 10.1016/s0165-0327(02)00091-5.
Reference Type
BACKGROUND
Pennington BF, Ozonoff S. Executive functions and developmental psychopathology. J Child Psychol Psychiatry. 1996 Jan;37(1):51-87. doi: 10.1111/j.1469-7610.1996.tb01380.x.
Reference Type
BACKGROUND
Sax KW, Strakowski SM, Zimmerman ME, DelBello MP, Keck PE Jr, Hawkins JM. Frontosubcortical neuroanatomy and the continuous performance test in mania. Am J Psychiatry. 1999 Jan;156(1):139-41. doi: 10.1176/ajp.156.1.139.
Reference Type
BACKGROUND
Walcott CM, Landau S. The relation between disinhibition and emotion regulation in boys with attention deficit hyperactivity disorder. J Clin Child Adolesc Psychol. 2004 Dec;33(4):772-82. doi: 10.1207/s15374424jccp3304_12.
Reference Type
BACKGROUND
Wilder-Willis KE, Sax KW, Rosenberg HL, Fleck DE, Shear PK, Strakowski SM. Persistent attentional dysfunction in remitted bipolar disorder. Bipolar Disord. 2001 Apr;3(2):58-62. doi: 10.1034/j.1399-5618.2001.030202.x.
Reference Type
BACKGROUND
Wozniak J, Biederman J, Kiely K, Ablon JS, Faraone SV, Mundy E, Mennin D. Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry. 1995 Jul;34(7):867-76. doi: 10.1097/00004583-199507000-00010.
Reference Type
BACKGROUND
Other Identifiers
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