A Long-Term, Safety Study With a Flexible Dose Range of KW-6002 in Patients With Motor Response Complications on Levodopa/Carbidopa Therapy

NCT ID: NCT00955045

Last Updated: 2024-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Study Classification

INTERVENTIONAL

Study Start Date

2002-08-31

Study Completion Date

2003-10-31

Brief Summary

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The primary objective of this study was to establish the long-term tolerability and safety of istradefylline treatment in subjects with Parkinson's disease treated with levodopa/carbidopa. In addition, treatment response and maintenance of response were assessed.

Detailed Description

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Conditions

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Parkinson's Disease

Study Groups

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istradefylline

Group Type EXPERIMENTAL

istradefylline

Intervention Type DRUG

Interventions

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istradefylline

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Eligible subjects were:

* male or female
* at least 30 years of age
* had completed participation in a prior double-blind istradefylline trial
* met United Kingdom's Parkinson's Disease Society (UKPDS) brain bank criteria (Step 1 and Step 2) for Parkinson's disease and the severity of the Parkinson's disease was defined as Stages 2-4 on the Modified Hoehn and Yahr Scale while in the OFF state
* had been treated with levodopa for at least 1 year
* had been on a stable Parkinson's disease regimen within normal therapeutic ranges including levodopa for at least 4 weeks before Baseline
* were currently taking at least 4 doses of levodopa per day (3 doses per day if at least 2 doses contained slow-release formulation)
* had predictable end-of-dose wearing-off

Exclusion Criteria

* none
Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kyowa Kirin, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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48 Centers in the US and 4 in Canada

Princeton, New Jersey, United States

Site Status

Countries

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United States

Other Identifiers

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6002-US-007

Identifier Type: -

Identifier Source: org_study_id

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