Action in Diabetes and Vascular Disease Preterax and Diamicron MR Controlled Evaluation Post Trial Observational Study
NCT ID: NCT00949286
Last Updated: 2014-05-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
8494 participants
OBSERVATIONAL
2010-01-31
2014-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Ability to provide informed consent
Exclusion Criteria
ALL
No
Sponsors
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Servier
INDUSTRY
The George Institute
OTHER
Responsible Party
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Principal Investigators
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John P Chalmers
Role: PRINCIPAL_INVESTIGATOR
The George Institute
Stephen MacMahon
Role: PRINCIPAL_INVESTIGATOR
The George Institute
Locations
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LCC 80 - Canberra Hospital
Garran, Australian Capital Territory, Australia
LCC 28 - Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia
LCC 48 - Gosford
Gosford, New South Wales, Australia
LCC 59 - Liverpool Hospital
Liverpool, New South Wales, Australia
LCC 78 - Wentworth Diabetes Centre
Penrith, New South Wales, Australia
LCC 56 - Prince of Wales Hospital
Randwick, New South Wales, Australia
LCC 55 - Royal North Shore Hospital
St Leonards, New South Wales, Australia
LCC 23 - Wollongong Hospital
Wollongong, New South Wales, Australia
LCC 24 - Mater Hospital
Brisbane, Queensland, Australia
LCC 42 - Princess Alexandra Hospital
Brisbane, Queensland, Australia
LCC 74 - Redcliffe Hospital
Redcliffe, Queensland, Australia
LCC 43 - Gold Coast Hospital
Southport, Queensland, Australia
LCC 114 - Townsville Mater Hospital
Townsville, Queensland, Australia
LCC 73 - Repatriation General Hospital
Daw Park, South Australia, Australia
LCC 66 - Lyell McEwin Health
Elizabeth Vale, South Australia, Australia
LCC 61 - Launceston General Hospital
Launceston, Tasmania, Australia
LCC 65 - Dandenong Hospital
Dandenong, Victoria, Australia
LCC 33 - The Northern Hospital
Epping, Victoria, Australia
LCC 32 - Austin & Repatriation Hospital
Heidelburg, Victoria, Australia
LCC 76 - The Alfred Hospital
Melbourne, Victoria, Australia
LCC 109 - Rural Clinical Trials Research Unit
Shepparton, Victoria, Australia
LCC 50 - Fremantle Hospital
Fremantle, Western Australia, Australia
LCC 468 - Calgary Metabolic Education and Research Centre
Calgary, Alberta, Canada
LCC 454 University of British Columbia
Vancouver, British Columbia, Canada
LCC 467 - Queen Elizabeth II Health Science Centre
Halifax, Nova Scotia, Canada
LCC 465 - St. Joseph's Health Centre
London, Ontario, Canada
LCC 459 - University of Toronto
Toronto, Ontario, Canada
LCC 452 - Centre de recherche clinique de Laval
Laval, Quebec, Canada
LCC 453 - Centre hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada
LCC 460 - Centre Hospitalier de L'universitaire de Sherbrooke
Sherbrooke, Quebec, Canada
LCC 466 - Centre de recherche d'endocrinologie
Sherbrooke, Quebec, Canada
LCC 470 - Hôpital Laval
Ste-Foy, Quebec, Canada
LCC 643 - 2nd Aff Hospital of Baotou Medical College
Baotou, , China
LCC 644 - Baotou Iron & Steel Corporation's Hospital,
Baotou, , China
LCC 600 - Center Hospital of Aviation
Beijing, , China
LCC 601 - 305 Hospital of Chinese PLA
Beijing, , China
LCC 602 - Chinese PLA General Hospital
Beijing, , China
LCC 623 - Beijing 306 Hospital
Beijing, , China
LCC 626 - First Hospital of Peking University
Beijing, , China
LCC 627 - Peking Union Medical College Hospital
Beijing, , China
LCC 628 - Capital Steel Hospital
Beijing, , China
LCC 629 - Aff Beijing Tongren Hospital
Beijing, , China
LCC 630 - Beijing Hypertension League Institute
Beijing, , China
LCC 631 - Beijing Jiuxianqiao Hospital
Beijing, , China
LCC 632 - Dept Endocrinology Beijing 306 Hospital
Beijing, , China
LCC 633 - Cardiovascular Institute & Fu Wai Hospital
Beijing, , China
LCC 634 - Beijing Anzhen Hospital
Beijing, , China
LCC 637 - Chinese Air Force General Hospital
Beijing, , China
LCC 661 - Institute of Gerontology of Benxi City
Benxi, , China
LCC 607 - People's Hospital of Binzhou City
Binzhou, , China
LCC 609 - Xiang-ya Hospital,
Changsha, , China
LCC 620 - Municipal Hospital of Chengdou
Chengdu, , China
LCC 657 - The 1st Aff Hospital
Chengdu, , China
LCC 610 - Second Affiliated Hospital of Dalian Medical University
Dalian, , China
LCC 624 - The First Affiliated Hospital of Fujian Medical University
Fuzhou, , China
LCC 658 - The 1st Aff Hospital of Guiyang Medical College
Guiyang, , China
LCC 641 - The 2nd Aff Hospital of Harbin Medical University
Harbin, , China
LCC 653 - Aff Hospital of Anhui Medical University
Hefei, , China
LCC 642 - The Institute of Aged Gerontology of Inner Mongolia
Hohhot, , China
LCC 606 - Shandong Academy of Medical Sciences,
Jin’an, , China
LCC 660 - Shandong Academy of Medical Sciences
Jin’an, , China
LCC 622 - The First People's Hospital of Lianyungang City
Lianyungang, , China
LCC 654 - The 3rd Aff Hospital of Jiangxi Medical University
Nanchang, , China
LCC 655 - The 1st Aff Hospital of Jiangxi Medical College
Nanchang, , China
LCC 651 - Jiangsu Institute of Geriatrics,
Nanjing, , China
LCC 608 - Qingdao City Hospital
Qingdao, , China
LCC 603 - Rujin Hospital
Shanghai, , China
LCC 635 -Aff Ruijin Hospital of Shanghai Second Medical University
Shanghai, , China
LCC 636 - Chang Zheng Hospital of Shanghai
Shanghai, , China
LCC 638 - Shanghai 6th People's Hospital
Shanghai, , China
LCC 611 - Hua Tai Hospital
Shenyang, , China
LCC 618 - Hebei Academy of Medical Sciences
Shijiazhuang, , China
LCC 646 - The 2nd Aff Hospital of Hebei Medical University
Shijiazhuang, , China
LCC 613 - Cardiovascular Institute of Shanxi Province
Taiyuan, , China
LCC 645 - Hospital of Kailuan
Tangshan, , China
LCC 639 - Metabolic Disease Hospital of Tianjin Medical University
Tianjin, , China
LCC 640 - 3rd Hospital of Tianjin City
Tianjin, , China
LCC 619 - The First Hospital of Ning Bo City Municipal
Xinning, , China
LCC 647 - First Hospital of Yang Quan City
Yangquan, , China
LCC 614 -The First Affiliated Hospital of Henan Medical University
Zhengzhou, , China
LCC 616 - Center Hospital of Zhumadian City
Zhumadian, , China
LCC 437 - Metabolicke Centrum
Neratovice, , Czechia
LCC 372- Fakultni Nemocnice
Ostrava-Poruba, , Czechia
LCC 438 - Diabetologicka ambulance
Písek, , Czechia
Lcc 435 - Ikem
Prague, , Czechia
LCC 369- Masarykova Nemocnice
Ústí nad Labem, , Czechia
LCC 280 - Tallinn Central
Tallinn, , Estonia
LCC 281 - Dept of Medicine
Tartu, , Estonia
LCC 320 - CHU Angers
Angers, , France
LCC 376 - CH Avignon - Hôpital Henri Duffaut
Avignon, , France
LCC 375 - CH Nevers
Nevers, , France
LCC 373 - CHU Hopital Caremeau
Nîmes, , France
LCC 329 - CHU Bichat
Paris, , France
LCC 315 - Hôpital Jean Bernard la Miletrie
Poitiers, , France
LCC 310 - Hôpital Sud
Rennes, , France
LCC 304 - CHU Hôpital Civil
Strasbourg, , France
LCC 374 - CHU Hôpital Jeanne d' Arc
Toul, , France
LCC 377 - Zentrum fur Klinische Studien
Dresden, , Germany
LCC 330 - Klinikyum der Universitat Munchen
Munich, , Germany
LCC 336 - Heart Center Foundation-DRC Ltd
Balatonfüred, , Hungary
LCC 335 - Bajcsy Zsilinszky Kórház
Budapest, , Hungary
Lcc 740 - Aiims
Delhi, , India
LCC 744 - Care Hospital
Hyderabad, , India
LCC 741 - Madras Diabetic Research Foundation
Madras, , India
LCC 832 - Portincula Hospital
Ballinasloe, , Ireland
LCC 514 - Beaumont Hospital
Dublin, , Ireland
LCC 810 - Mater Hospital
Dublin, , Ireland
LCC 817 - St James Hospital
Dublin, , Ireland
LCC 806 - Adelaide & Meadth Hospital
Tallaght, , Ireland
LCC 418 - Ospedale San Gerado
Milan, , Italy
LCC 270 - Institute of Cardiology
Kaunas, , Lithuania
LCC 273 - Institute Psychophysiology and Rehabilitation
Palanga, , Lithuania
LCC 901 - Penang Medical College
George Town, , Malaysia
LCC 903 - Hospital Ipoh
Ipoh, , Malaysia
LCC 904 - Universiti Sains Malaysia
Kota Bharu, , Malaysia
LCC 902 - University of Malaya Medical Centre
Kuala Lumpur, , Malaysia
Universiti Kebangsaan Malaysia & Universiti Teknologi MARA
Putrajaya, , Malaysia
LCC 352 - Justus Medical Research
Eindhoven, , Netherlands
LCC 354 - Stichting Huisartsen Laboratorium
Etten-Leur, , Netherlands
LCC 347 - Martini Ziekenhuis
Groningen, , Netherlands
LCC 850 - Andromed Groningen
Groningen, , Netherlands
LCC 351 - Andromed Rotterdam
Rotterdam, , Netherlands
LCC 852 - Andromed Baarn
Rotterdam, , Netherlands
LCC 851 - Andromed Oost
Velp, , Netherlands
LCC 356 - Huisartsenpraktijk Tollenslaan
Zeist, , Netherlands
LCC 11 - Middlemore Hospital
Auckland, , New Zealand
LCC 14 - North Shore Hospital
Auckland, , New Zealand
LCC 12 - Christchurch Hospital
Christchurch, , New Zealand
LCC 5 - Hawkes Bay Hospital
Hastings, , New Zealand
LCC 2 - Palmerston North Hospital
Palmerston North, , New Zealand
LCC 91 - Timaru Hospital
Timaru, , New Zealand
LCC 6 Waikato Hospital
Waikato, , New Zealand
LCC 1 - Wellington Hospital
Wellington, , New Zealand
LCC 909 - Makati Medical Center
Makati City, Manila, Philippines
LCC 906 - Philippine General Hospital
Manila, , Philippines
LCC 907 - East Avenue Medical Centre
Quezon City, , Philippines
LCC 908 - Diabetes Foundation
Quezon City, , Philippines
LCC 426 - NZOZ Specjalistyczna Poradnia Endokrynologii
Elblag, , Poland
LCC 382 - Puls Med
Katowice, , Poland
LCC 381 - I Klinika Kardiologii
Krakow, , Poland
LCC 383 - Klinika Chorob Metabolicznych
Krakow, , Poland
LCC 389 - Zakład Angiologii
Krakow, , Poland
LCC 390 - Klinika Choroby Wiencowej
Krakow, , Poland
LCC 380 - I Oddzial Chorob Wewnetrznych
Kutno, , Poland
LCC 392 - Osrodek Diabetologii
Olsztyn, , Poland
LCC 378 - Klinika Nefrologii
Poznan, , Poland
LCC 394 - II Oddzial Chorob Wewnetrznvch
Radom, , Poland
LCC 420 - Russian Peoples Friendship University
Moscow, , Russia
LCC 421 - St Petersburg State Medical University
Saint Petersburg, , Russia
LCC 424 - Research Institute of Cardiology
Saint Petersburg, , Russia
LCC 254 - Poliklinikou Vychod
Košice, , Slovakia
LCC 252 - Nemocnica s poliklinikou
Levice, , Slovakia
LCC 253 - Nemocnica s poliklinikou
Lučenec, , Slovakia
LCC 517 - Aberdeen Royal Infirmary
Aberdeen, , United Kingdom
LCC 813 - Monklands Hospital
Airdrie, , United Kingdom
LCC 819 - Royal United Hospital
Bath, , United Kingdom
LCC 815 - City Hospital
Birmingham, , United Kingdom
LCC 821 - West Byfleet Health Centre
Byfleet, , United Kingdom
LCC 594 - Glasgow Royal Infirmary
Glasgow, , United Kingdom
LCC 826 - St Mary's Hospital
Isle of Wight, , United Kingdom
LCC 533 - Leicester Royal Infirmary
Leicester, , United Kingdom
LCC 809 - Royal Liverpool University Hospital
Liverpool, , United Kingdom
LCC 543 - St Mary's
London, , United Kingdom
LCC 511 - Manchester Royal Infirmary
Manchester, , United Kingdom
LCC 829 - Northampton General Hospital
Northampton, , United Kingdom
LCC 830 - George Eliot Hospital
Nuneaton, , United Kingdom
LCC 812 - Royal Alexandra Hospital
Paisley, , United Kingdom
LCC 816 - Peninsula Medical School Headquarters
Plymouth, , United Kingdom
LCC 820 - The Diabetes Centre
Reading, , United Kingdom
LCC 827 - Northern General Hospital
Sheffield, , United Kingdom
Sheffield Hallamshire
Sheffield, , United Kingdom
LCC 831 - Warwick General Hospital
Warwick, , United Kingdom
Countries
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References
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Patel A; ADVANCE Collaborative Group; MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee DE, Hamet P, Heller S, Liu LS, Mancia G, Mogensen CE, Pan CY, Rodgers A, Williams B. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet. 2007 Sep 8;370(9590):829-40. doi: 10.1016/S0140-6736(07)61303-8.
ADVANCE Collaborative Group; Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2560-72. doi: 10.1056/NEJMoa0802987. Epub 2008 Jun 6.
Wang N, Harris K, Hamet P, Harrap S, Mancia G, Poulter N, Williams B, Zoungas S, Woodward M, Chalmers J, Rodgers A. Cumulative Systolic Blood Pressure Load and Cardiovascular Risk in Patients With Diabetes. J Am Coll Cardiol. 2022 Sep 20;80(12):1147-1155. doi: 10.1016/j.jacc.2022.06.039.
Oshima M, Jun M, Ohkuma T, Toyama T, Wada T, Cooper ME, Hadjadj S, Hamet P, Harrap S, Mancia G, Marre M, Williams B, Chalmers J, Woodward M, Perkovic V; ADVANCE Collaborative Group. The relationship between eGFR slope and subsequent risk of vascular outcomes and all-cause mortality in type 2 diabetes: the ADVANCE-ON study. Diabetologia. 2019 Nov;62(11):1988-1997. doi: 10.1007/s00125-019-4948-4. Epub 2019 Jul 13.
Mohammedi K, Woodward M, Hirakawa Y, Zoungas S, Colagiuri S, Hamet P, Harrap S, Poulter N, Matthews DR, Marre M, Chalmers J; ADVANCE Collaborative Group. Presentations of major peripheral arterial disease and risk of major outcomes in patients with type 2 diabetes: results from the ADVANCE-ON study. Cardiovasc Diabetol. 2016 Sep 2;15(1):129. doi: 10.1186/s12933-016-0446-x.
Wong MG, Perkovic V, Chalmers J, Woodward M, Li Q, Cooper ME, Hamet P, Harrap S, Heller S, MacMahon S, Mancia G, Marre M, Matthews D, Neal B, Poulter N, Rodgers A, Williams B, Zoungas S; ADVANCE-ON Collaborative Group. Long-term Benefits of Intensive Glucose Control for Preventing End-Stage Kidney Disease: ADVANCE-ON. Diabetes Care. 2016 May;39(5):694-700. doi: 10.2337/dc15-2322. Epub 2016 Mar 22.
Zoungas S, Chalmers J, Neal B, Billot L, Li Q, Hirakawa Y, Arima H, Monaghan H, Joshi R, Colagiuri S, Cooper ME, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Lisheng L, Mancia G, Marre M, Matthews DR, Mogensen CE, Perkovic V, Poulter N, Rodgers A, Williams B, MacMahon S, Patel A, Woodward M; ADVANCE-ON Collaborative Group. Follow-up of blood-pressure lowering and glucose control in type 2 diabetes. N Engl J Med. 2014 Oct 9;371(15):1392-406. doi: 10.1056/NEJMoa1407963. Epub 2014 Sep 19.
Other Identifiers
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ADVANCE-ON
Identifier Type: -
Identifier Source: org_study_id
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