A Trial of Degarelix in Patients With Prostate Cancer

NCT ID: NCT00946920

Last Updated: 2014-06-02

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

859 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-06-30

Study Completion Date

2011-03-31

Brief Summary

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A phase 3, open-label, parallel group, one year trial comparing the efficacy and safety of degarelix 3-month depot with the established therapy goserelin acetate 3-month implant in patients with prostate cancer.

Detailed Description

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Conditions

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Prostate Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Degarelix 240 mg/480 mg

Group Type EXPERIMENTAL

Degarelix

Intervention Type DRUG

The degarelix doses were administered by subcutaneous (s.c.) injections into the abdominal wall. A starting dose of 240 mg degarelix was administered on Day 0. One month later a maintenance dose of 480 mg was administered. This was repeated after 4, 7, and 10 months (ie a total of 5 administrations).

Goserelin acetate

Group Type ACTIVE_COMPARATOR

Goserelin acetate

Intervention Type DRUG

The goserelin doses were administered by subcutaneous (s.c.) implants into the abdominal wall. An initial dose of 3.6 mg goserelin was administered on Day 0. One month later a subsequent dose of 10.8 mg was administered and this was repeated after 4, 7, and 10 months (ie a total of 5 implants).

Interventions

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Degarelix

The degarelix doses were administered by subcutaneous (s.c.) injections into the abdominal wall. A starting dose of 240 mg degarelix was administered on Day 0. One month later a maintenance dose of 480 mg was administered. This was repeated after 4, 7, and 10 months (ie a total of 5 administrations).

Intervention Type DRUG

Goserelin acetate

The goserelin doses were administered by subcutaneous (s.c.) implants into the abdominal wall. An initial dose of 3.6 mg goserelin was administered on Day 0. One month later a subsequent dose of 10.8 mg was administered and this was repeated after 4, 7, and 10 months (ie a total of 5 implants).

Intervention Type DRUG

Other Intervention Names

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Firmagon FE200486 Zoladex

Eligibility Criteria

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Inclusion Criteria

* 18 years or older.
* Has a histological confirmed prostate cancer Gleason graded).
* Has a screening testosterone above 2.2 ng/mL.
* Rising prostate-specific antigen (PSA).
* Has Eastern Cooperative Oncology Group (ECOG) score of ≤ 2.
* Has a life expectancy of at least one year.

Exclusion Criteria

* Current or previous hormone therapy.
* Has received therapy with finasteride and dutasteride within 12 weeks and 25 weeks, respectively, prior to screening.
* Has a history of severe untreated asthma, anaphylactic reactions, or severe urticaria and/or angioedema.
* Has a heart insufficiency.
* Has a previous history or presence of another malignancy, other than prostate cancer or treated squamous/basal cell carcinoma of the skin, within the last five years.
* Has a clinically significant medical condition (other than prostate cancer) including, but not limited to, renal, haematological, gastrointestinal, endocrine, cardiac, neurological, or psychiatric disease and alcohol or drug abuse or any other condition which may affect the patient's health or the outcome of the trial as judged by the Investigator.
* Has received an investigational drug within the last 28 days before the Screening Visit or longer if considered to possibly influencing the outcome of the current trial.
* Is candidate for curative therapy, i.e. radical prostatectomy or radiotherapy.
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Ferring Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Development Support

Role: STUDY_DIRECTOR

Ferring Pharmaceuticals

Locations

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Urology Centers Of Alabama

Homewood, Alabama, United States

Site Status

Arkansas Urology

Little Rock, Arkansas, United States

Site Status

Urology Associates of Central CA

Fresno, California, United States

Site Status

Medresearch

La Mesa, California, United States

Site Status

South Orange County Medical Research Center

Laguna Hills, California, United States

Site Status

Atlantic Urology Medical Group

Long Beach, California, United States

Site Status

Anschutz Cancer Pavillion

Aurora, Colorado, United States

Site Status

The Urology Center of Colorado

Denver, Colorado, United States

Site Status

Urological Associates of Bridgeport, P.C.

Trumbull, Connecticut, United States

Site Status

Urology Associates of Dover, PA

Dover, Delaware, United States

Site Status

Walter Reed Army Medical Center

Washington D.C., District of Columbia, United States

Site Status

South Florida Medical Research

Aventura, Florida, United States

Site Status

Florida Foundation for Healthcare Research

Ocala, Florida, United States

Site Status

Georgis Patsias, MD, PA

Wellington, Florida, United States

Site Status

Palm Beach Urology Associates, PA

Wellington, Florida, United States

Site Status

Indiana University Department of Urology

Indianapolis, Indiana, United States

Site Status

Kansas City Urology Care, PA

Overland Park, Kansas, United States

Site Status

Urological Associates of Englewood

Englewood, New Jersey, United States

Site Status

Hamilton Urology PA

Hamilton, New Jersey, United States

Site Status

Lawrenceville Urology

Lawrenceville, New Jersey, United States

Site Status

Urology Group of New Mexico, PC

Albuquerque, New Mexico, United States

Site Status

Capital Region Urological Surgeons and Research Associates

Albany, New York, United States

Site Status

Hudson Valley Urology P.C.

Poughkeepsie, New York, United States

Site Status

Metrolina Urology Clinic

Charlotte, North Carolina, United States

Site Status

Northeast Urology Research

Concord, North Carolina, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Alliance Urology Specialists

Greensboro, North Carolina, United States

Site Status

Urologic Consultants of SEPA

Bala-Cynwyd, Pennsylvania, United States

Site Status

State College Urologic Association

State College, Pennsylvania, United States

Site Status

Grand Strand Urology

Myrtle Beach, South Carolina, United States

Site Status

Urology Clinics of North Texas, PA

Dallas, Texas, United States

Site Status

Urology San Antonio Research

San Antonio, Texas, United States

Site Status

Urology of Virginia

Norfolk, Virginia, United States

Site Status

Virginia Urology Center

Richmond, Virginia, United States

Site Status

Urology of Virginia

Virginia Beach, Virginia, United States

Site Status

Seattle Urology Research Center

Burien, Washington, United States

Site Status

Cliniques Universitaires Saint-Luc

Brussels, , Belgium

Site Status

UZ Antwerpen

Edegem, , Belgium

Site Status

UZ Gent

Ghent, , Belgium

Site Status

AZ Groeninge - Campus Sint-Maarten

Kortrijk, , Belgium

Site Status

Southern Interior Medical Research Inc.

Kelowna, British Columbia, Canada

Site Status

Dr. Cal Andreou Research

Surrey, British Columbia, Canada

Site Status

Can-Med Clinical Research Inc.

Victoria, British Columbia, Canada

Site Status

Dr Gary Steinhoff Clinical Research

Victoria, British Columbia, Canada

Site Status

Bramalea Medical Centre

Brampton, Ontario, Canada

Site Status

Urology Associates / Urologic Medical Research

Kitchener, Ontario, Canada

Site Status

Mor Urology, Inc.

Newmarket, Ontario, Canada

Site Status

Ivestigational site

Scarborough Village, Ontario, Canada

Site Status

Anthony Skehan Medicine Professionals Corporation

Thunder Bay, Ontario, Canada

Site Status

Bloor West Professional Center

Toronto, Ontario, Canada

Site Status

The Health Institute for Men

Toronto, Ontario, Canada

Site Status

Uro Laval

Laval, Quebec, Canada

Site Status

Notre Dame Hopital

Montreal, , Canada

Site Status

Urocentrum Brno

Brno, , Czechia

Site Status

Nemocnice Jindrichuv Hradec, a.s.

Jindřichův Hradec, , Czechia

Site Status

Kromerizska nemocnice a.s.

Kroměříž, , Czechia

Site Status

Slezska nemocnice

Opava, , Czechia

Site Status

Fakultni nemocnice v Motole, Praha 5

Prague, , Czechia

Site Status

Fakultni Thomayerova nemocnice s poliklinikou, Praha 4

Prague, , Czechia

Site Status

Vseobecna fakultni nemocnice v Praze, Praha 2

Prague, , Czechia

Site Status

Krajska nemocnice T. Bati a.s.

Zlín, , Czechia

Site Status

Pietarsaaren sairaala/ Malmin terveydenhuoltoalue

Jakobstad, , Finland

Site Status

Pohjois-Karjalan keskussairaala

Joensuu, , Finland

Site Status

ODL Terveys Oy

Oulu, , Finland

Site Status

Tampereen yliopistollinen sairaala

Tampere, , Finland

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Investigational site

Aachen, , Germany

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Investigational site

Kirchheim, , Germany

Site Status

Klinikum Mannheim Universitätsklinikum GmbH

Mannheim, , Germany

Site Status

Urologische Studienpraxis

Nürtingen, , Germany

Site Status

Fövárosi Önkormányzat Bajcsy-Zsilinszky Kórház

Budapest, , Hungary

Site Status

Fövárosi Önkormányzat uzsoki utcai Kórház

Budapest, , Hungary

Site Status

Semmelweis Egyetem

Budapest, , Hungary

Site Status

Dombóvári Szent Lukács Egészségügyi Kht.

Dombóvár, , Hungary

Site Status

Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház

Miskolc, , Hungary

Site Status

Miskolci Semmelweis Ignác Egészségügyi Központ és Egyetemi Oktató Kórház Nonprofit Kft

Miskolc, , Hungary

Site Status

Pécsi Tudományegyetem

Pécs, , Hungary

Site Status

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ

Szeged, , Hungary

Site Status

Jávorszky Ödön Kórház

Vác, , Hungary

Site Status

Hospital Christus Muguerza del Parque

Chihuahua City, Chihuahua, Mexico

Site Status

Hospital Aranda de la Parra , S.A. de C.V.

León, Guanajuato, Mexico

Site Status

Hospital Angeles Culiacan

Culiacán, Sinaloa, Mexico

Site Status

Consultorio de Especialidad en Urologia Privado, Durango

Durango, , Mexico

Site Status

Centro Medico Dalinde

Mexico City, , Mexico

Site Status

Hospital Angeles Lindavista

Mexico City, , Mexico

Site Status

Operadora MSB, S.A. de C.V. (Medica Sur CIF-BIOTEC)

Mexico City, , Mexico

Site Status

Consultorio Medico

Zapopan, Jalisco, , Mexico

Site Status

AMC

Amsterdam, , Netherlands

Site Status

Catharina-ziekenhuis

Eindhoven, , Netherlands

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Atrium MC

Heerlen, , Netherlands

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MC Haaglanden

The Hague, , Netherlands

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SPZOZ Wojewodzki Szpital Zespolony im. J.Sniadeckiego

Bialystok, , Poland

Site Status

Centrum Medyczne Medur Sp. z o.o.

Bielsko-Biala, , Poland

Site Status

Gabinet Lekarski

Krakow, , Poland

Site Status

Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Slupsku

Słupsk, , Poland

Site Status

LexMedica

Wroclaw, , Poland

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Private Medical Center

Arad, , Romania

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Brasov Emergency Clinical County Hospital

Brasov, , Romania

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"Fundeni" Clinical Institute

Bucharest, , Romania

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"Sfantul Ioan" Emergency Clinical Hospital

Bucharest, , Romania

Site Status

Dinu Uromedica

Bucharest, , Romania

Site Status

Prof. Dr. Th. Burghele Clinical Urology Hospital

Bucharest, , Romania

Site Status

PROVITA 2000 Medical Center

Constanța, , Romania

Site Status

"Dr. C.I. Parhon" Clinical Hospital

Lasi, , Romania

Site Status

Vita Care Flav Medical Center

Piteşti, , Romania

Site Status

Emergency County Clinical Hospital Sibiu

Sibiu, , Romania

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City Clinical Hospital #60

Moscow, , Russia

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Moscow State University of Medicine and Dentistry

Moscow, , Russia

Site Status

"Clinic Andros" LLC

Saint Petersburg, , Russia

Site Status

"Orkli" LLC

Saint Petersburg, , Russia

Site Status

City Hospital # 26

Saint Petersburg, , Russia

Site Status

City Hospital #15

Saint Petersburg, , Russia

Site Status

St. Petersburg State Medical University n.a. I.P. Pavlov

Saint Petersburg, , Russia

Site Status

St.Petersburg Multi-Field City Hospital #2

Saint Petersburg, , Russia

Site Status

Regional Clinical Oncology Center

Vladimir, , Russia

Site Status

Municipal Institution "Cherkasy Regional Oncology Dispensary"

Cherkassy, , Ukraine

Site Status

Dnipropetrovsk State Medical Academy

Dnipropetrovsk, , Ukraine

Site Status

Donetsk Regional Clinical Territorial Medical Association

Donetsk, , Ukraine

Site Status

Ivano-Frankivsk Regional Oncology Dispensary

Ivano-Frankivsk, , Ukraine

Site Status

Regional Clinical Center of Urology and Nephrology n.a. V.I.Shapoval

Kharkiv, , Ukraine

Site Status

Kyiv City Clinical Hospital #3

Kyiv, , Ukraine

Site Status

Odesa Regional Clinical Hospital

Odesa, , Ukraine

Site Status

Municipal Institution "Zaporizhzhia Regional Clinical Hospital"

Zaporizhzhya, , Ukraine

Site Status

Castle Hill Hospital

Cottingham, , United Kingdom

Site Status

Ipswich Hospital

Ipswich, , United Kingdom

Site Status

Royal Liverpool University Hospital

Liverpool, , United Kingdom

Site Status

The Royal Marsden NHS Foundation Trust

Sutton, , United Kingdom

Site Status

Countries

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United States Belgium Canada Czechia Finland Germany Hungary Mexico Netherlands Poland Romania Russia Ukraine United Kingdom

References

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Zengerling F, Jakob JJ, Schmidt S, Meerpohl JJ, Blumle A, Schmucker C, Mayer B, Kunath F. Degarelix for treating advanced hormone-sensitive prostate cancer. Cochrane Database Syst Rev. 2021 Aug 5;8(8):CD012548. doi: 10.1002/14651858.CD012548.pub2.

Reference Type DERIVED
PMID: 34350976 (View on PubMed)

Other Identifiers

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2008-005276-27

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

FE200486 CS35

Identifier Type: -

Identifier Source: org_study_id

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