Extension Study Investigating the Long-Term Safety of Degarelix One-Month Depots in Patients With Prostate Cancer

NCT ID: NCT00117286

Last Updated: 2025-12-18

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

57 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-03-31

Study Completion Date

2009-11-30

Brief Summary

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This was an extension study for the study FE200486 CS14 (NCT00116779). Each participant was to be treated until he was discontinued or withdrawn from the study, or a marketing authorization for degarelix had been obtained.

The study was terminated when all ongoing participants had been treated for at least 5 years.

Detailed Description

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Participants who completed the main FE200486 CS14 study initially continued with the same dose in the FE200486 CS14A extension study. A protocol amendment changed the dosage to 160 mg (40 mg/mL) for all study participants.

The data include data from the participants who participated in both the main study (FE200486 CS14; NCT00116779) and the extension study FE200486 CS14A.

Conditions

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Prostate Cancer

Keywords

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Prostate Cancer Androgen ablation therapy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Degarelix (60 mg to 160 mg)

Participants who completed the CS14 study in the Degarelix 60 mg (20 mg/mL) arm continued that dose into the CS14A extension study. A protocol amendment in March 2006 changed the dosage to 160 mg (40 mg/mL) for all study participants.

Group Type EXPERIMENTAL

Degarelix

Intervention Type DRUG

Drug supplied as a powder to be dissolved in the solvent for solution for injection. Degarelix given by subcutaneous injection every 28 days until the end of the study.

Degarelix (80 mg to 160 mg)

Participants who completed the CS14 study in the Degarelix 80 mg (20 mg/mL) arm continued that dose into the CS14A extension study. A protocol amendment in March 2006 changed the dosage to 160 mg (40 mg/mL) for all study participants.

Group Type EXPERIMENTAL

Degarelix

Intervention Type DRUG

Drug supplied as a powder to be dissolved in the solvent for solution for injection. Degarelix given by subcutaneous injection every 28 days until the end of the study.

Interventions

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Degarelix

Drug supplied as a powder to be dissolved in the solvent for solution for injection. Degarelix given by subcutaneous injection every 28 days until the end of the study.

Intervention Type DRUG

Other Intervention Names

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Degarelix acetate, FE200486

Eligibility Criteria

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Inclusion Criteria

* Has given written consent prior to any study-related activity being performed. A study-related activity is defined as any procedure that would not have been performed during the normal management of the patient.
* Has completed study FE200486 CS14 through visit 22.

Exclusion Criterion:

* Has been withdrawn from the FE200486 CS14 study.
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Ferring Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Development Support

Role: STUDY_DIRECTOR

Ferring Pharmaceuticals

Locations

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Urology Centers of Alabama

Homewood, Alabama, United States

Site Status

Advanced Urology Medical Center

Anaheim, California, United States

Site Status

West Coast Clinical Research

Tarzana, California, United States

Site Status

Western Clinical Research

Torrance, California, United States

Site Status

Urology Associate PC'

Denver, Colorado, United States

Site Status

South Florida Medical Research

Aventura, Florida, United States

Site Status

SW Florida Urological Associates

Fort Myers, Florida, United States

Site Status

Northeast Indiana Research, LLC

Fort Wayne, Indiana, United States

Site Status

Regional Urology

Shreveport, Louisiana, United States

Site Status

Lawrenceville Urology

Lawrenceville, New Jersey, United States

Site Status

The Urology Center

Greensboro, North Carolina, United States

Site Status

State College Urologic Association

State College, Pennsylvania, United States

Site Status

University Urological Research Institute

Providence, Rhode Island, United States

Site Status

Urology San Antonio Research

San Antonio, Texas, United States

Site Status

University of Vermont, Dept of Surgery

South Burlington, Vermont, United States

Site Status

Virginia Urology Center

Richmond, Virginia, United States

Site Status

Investigational site

Seattle, Washington, United States

Site Status

Can-Med Clinical Research, Inc.

Victoria, British Columbia, Canada

Site Status

The Male and Female Health and Research Centers

Barrie, Ontario, Canada

Site Status

Brantford Urology Research

Brantford, Ontario, Canada

Site Status

Burlington Professional Care

Burlington, Ontario, Canada

Site Status

The Female/Male Health Centres

Oakville, Ontario, Canada

Site Status

Countries

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United States Canada

Other Identifiers

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FE200486 CS14A

Identifier Type: -

Identifier Source: org_study_id