Study of the Effect of Eicosanoids on Contractile Activity of Pregnant Human Myometrium in Pathological Situation
NCT ID: NCT00939744
Last Updated: 2015-03-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
130 participants
OBSERVATIONAL
2009-05-31
2015-10-31
Brief Summary
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Objectives:
Primary objective: To compare the balance of different metabolic pathways of arachidonic acid (AA) of the pregnant human myometrium in pathological situations (preterm labor, uterine atony, prolonged pregnancy).
Specific objectives: i) To study the effect of derived from the AA on in vitro contractile activity of normal and pathological uterine tissues, and ii) detect and quantify the different sub-products of metabolism of AA in the uterine tissues (myometrium, fetal membranes and placenta).
The management of uterine contraction is in the heart of modern obstetrics year, yet the progress made in other specialties, based on the study of smooth muscle have not yet been transposed in obstetrics. A better understanding of systems for regulating the contraction is important in terms of 1) new physiological knowledge, but it could also be the source of 2) modification of strategies to take care of premature delivery (new Tocolytic), or 3) improving the efficiency of uterine muscle during delivery or 4) for treatment of patients with prolonged pregnancy.
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Detailed Description
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The sampling method. After birth, a biopsy will be perform from the lower segment of the uterus. After caesarean sections of membrane and placenta are collected.
The substances studied during isometric tension tests are part of the three degradation pathways of the AA.
1. new eicosanoids in cumulative dose (8,9-EET, 11,12-EET, 14,15-EET, 20-HETE), and in combination
2. enzyme inhibitors of the eicosanoids pathway (AUDA, MS-PPOH, DDMS), and the COX and LOX pathways (indomethacin), alone or in combination.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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EAU2
Women who will have a c-section at the CHUS
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* child with malformation,
* birth weight less than 2500 grams or greater than 4500g
18 Years
40 Years
FEMALE
No
Sponsors
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Fonds de la Recherche en Santé du Québec
OTHER_GOV
Université de Sherbrooke
OTHER
Responsible Party
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Jean-Charles Pasquier, MD, PhD
Dr
Principal Investigators
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Jean-Charles Pasquier, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Centre hospitalier de l'Université de Sherbrooke
Rousseau Éric, PhD
Role: PRINCIPAL_INVESTIGATOR
Université de Sherbrooke
Locations
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Centre hospitalier de l'Université de Sherbrooke
Sherbrooke, Quebec, Canada
Countries
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Central Contacts
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References
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Corriveau S, Pasquier JC, Blouin S, Bellabarba D, Rousseau E. Chronic levothyroxine and acute T3 treatments enhance the amplitude and time course of uterine contractions in human. Am J Physiol Endocrinol Metab. 2013 Mar 1;304(5):E478-85. doi: 10.1152/ajpendo.00346.2012. Epub 2012 Dec 18.
Other Identifiers
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09-040
Identifier Type: -
Identifier Source: org_study_id
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