Mechanisms of Neural Mobilization in the Treatment of Chronic Pain

NCT ID: NCT00929123

Last Updated: 2015-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-05-31

Study Completion Date

2009-06-30

Brief Summary

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The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in individuals with carpal tunnel syndrome. The investigators hypothesized that individuals receiving a neural mobilization technique known to directly stress the median nerve would demonstrate greater improvements in clinical pain and function, experimental pain sensitivity, and median nerve function than those receiving a sham technique.

Detailed Description

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Conditions

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Carpal Tunnel Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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neural mobilization

manual therapy technique known to directly stress the median nerve

Group Type EXPERIMENTAL

neural mobilization

Intervention Type PROCEDURE

manual therapy technique known to directly stress the median nerve

sham neural mobilization

manual therapy technique known to directly stress the median nerve without any stimulation.

Group Type PLACEBO_COMPARATOR

sham neural mobilization

Intervention Type PROCEDURE

sham technique mimicking the neural mobilization which is not specific to the median nerve

Healthy Controls

People without carpal tunnel syndrome for comparison

Group Type ACTIVE_COMPARATOR

healthy controls

Intervention Type OTHER

People without carpal tunnel syndrome for comparison

Interventions

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neural mobilization

manual therapy technique known to directly stress the median nerve

Intervention Type PROCEDURE

sham neural mobilization

sham technique mimicking the neural mobilization which is not specific to the median nerve

Intervention Type PROCEDURE

healthy controls

People without carpal tunnel syndrome for comparison

Intervention Type OTHER

Other Intervention Names

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upper limb tension test with median nerve bias

Eligibility Criteria

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Inclusion Criteria

* 18 to 70 years of age
* signs and symptoms of carpal tunnel syndrome for greater than 12 weeks

Exclusion Criteria

* non english speaking
* prior surgery for carpal tunnel syndrome
* systemic condition known to affect sensation
* chronic pain condition other than carpal tunnel syndrome
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Center for Complementary and Integrative Health (NCCIH)

NIH

Sponsor Role collaborator

University of Florida

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Steven Z George, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Florida Department of Physical Therapy

Locations

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University of Florida

Gainesville, Florida, United States

Site Status

Countries

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United States

References

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Bialosky JE, Bishop MD, Price DD, Robinson ME, Vincent KR, George SZ. A randomized sham-controlled trial of a neurodynamic technique in the treatment of carpal tunnel syndrome. J Orthop Sports Phys Ther. 2009 Oct;39(10):709-23. doi: 10.2519/jospt.2009.3117.

Reference Type RESULT
PMID: 19801812 (View on PubMed)

Bialosky JE, Bishop MD, Robinson ME, Price DD, George SZ. Heightened pain sensitivity in individuals with signs and symptoms of carpal tunnel syndrome and the relationship to clinical outcomes following a manual therapy intervention. Man Ther. 2011 Dec;16(6):602-8. doi: 10.1016/j.math.2011.06.003. Epub 2011 Jul 20.

Reference Type RESULT
PMID: 21764354 (View on PubMed)

Bialosky JE, Bishop MD, Price DD, Robinson ME, George SZ. The mechanisms of manual therapy in the treatment of musculoskeletal pain: a comprehensive model. Man Ther. 2009 Oct;14(5):531-8. doi: 10.1016/j.math.2008.09.001. Epub 2008 Nov 21.

Reference Type RESULT
PMID: 19027342 (View on PubMed)

Other Identifiers

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R21AT002796

Identifier Type: NIH

Identifier Source: secondary_id

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R21AT002796-01A1

Identifier Type: NIH

Identifier Source: secondary_id

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R21AT002796

Identifier Type: NIH

Identifier Source: org_study_id

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