C2 -CORVUS Cholesterol-Control (C2) Controlled Targets for High Vascular Risk Patients Using Effective Statins (CORVUS)

NCT ID: NCT00921752

Last Updated: 2009-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-05-31

Study Completion Date

2009-11-30

Brief Summary

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To demonstrate a higher percent rate of achieved target lipid goals among patients at high cardiovascular risk using more potent lipid-lowering treatment options including high-potency statins and combination therapies.

Detailed Description

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Conditions

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Cardiovascular Risk

Keywords

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Lipid therapy high CV risk lipid goal attainment High cardiovascular risk patients

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients at high cardiovascular risk

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients at high cardiovascular risk according to Framingham or SCORE rates

Exclusion Criteria

* Not eligible for lipid or statin therapy
* Intolerance to therapy
* Patients at low or intermediate CV risk
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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AstraZeneca

Principal Investigators

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Mark Laszlo, MD, PHD

Role: PRINCIPAL_INVESTIGATOR

County Hospital Bekes, Gyula

Csaba Csongvai, MD

Role: STUDY_DIRECTOR

AstraZeneca Hungary

Eva Gulyas

Role: STUDY_CHAIR

AstraZeneca Hungary

Locations

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Research Site

Baja, , Hungary

Site Status

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Békéscsaba, , Hungary

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Budapest, , Hungary

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Budapest III District, , Hungary

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Cegléd, , Hungary

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Debrecen, , Hungary

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Gyöngyös, , Hungary

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Gyula, , Hungary

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Jászberény, , Hungary

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Kalocsa, , Hungary

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Karcag, , Hungary

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Kecskemét, , Hungary

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Kisvárda, , Hungary

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Mohács, , Hungary

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Nyíregyháza, , Hungary

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Orosháza, , Hungary

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Pásztó, , Hungary

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Püspökladány, , Hungary

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Salgótarján, , Hungary

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Szarvas, , Hungary

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Szekszárd, , Hungary

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Szécsény, , Hungary

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Székesfehérvár, , Hungary

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Szolnok, , Hungary

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Tatabánya, , Hungary

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Vác, , Hungary

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Countries

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Hungary

References

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Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994 Nov 19;344(8934):1383-9.

Reference Type BACKGROUND
PMID: 7968073 (View on PubMed)

Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 1995 Nov 16;333(20):1301-7. doi: 10.1056/NEJM199511163332001.

Reference Type BACKGROUND
PMID: 7566020 (View on PubMed)

Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG, Brown L, Warnica JW, Arnold JM, Wun CC, Davis BR, Braunwald E. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med. 1996 Oct 3;335(14):1001-9. doi: 10.1056/NEJM199610033351401.

Reference Type BACKGROUND
PMID: 8801446 (View on PubMed)

Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med. 1998 Nov 5;339(19):1349-57. doi: 10.1056/NEJM199811053391902.

Reference Type BACKGROUND
PMID: 9841303 (View on PubMed)

Downs JR, Clearfield M, Weis S, Whitney E, Shapiro DR, Beere PA, Langendorfer A, Stein EA, Kruyer W, Gotto AM Jr. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA. 1998 May 27;279(20):1615-22. doi: 10.1001/jama.279.20.1615.

Reference Type BACKGROUND
PMID: 9613910 (View on PubMed)

Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002 Jul 6;360(9326):7-22. doi: 10.1016/S0140-6736(02)09327-3.

Reference Type BACKGROUND
PMID: 12114036 (View on PubMed)

De Backer G, Ambrosioni E, Borch-Johnsen K, Brotons C, Cifkova R, Dallongeville J, Ebrahim S, Faergeman O, Graham I, Mancia G, Manger Cats V, Orth-Gomer K, Perk J, Pyorala K, Rodicio JL, Sans S, Sansoy V, Sechtem U, Silber S, Thomsen T, Wood D; Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J. 2003 Sep;24(17):1601-10. doi: 10.1016/s0195-668x(03)00347-6. No abstract available.

Reference Type BACKGROUND
PMID: 12964575 (View on PubMed)

Other Identifiers

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NIS-CHU-DUM-2009/1

Identifier Type: -

Identifier Source: org_study_id