Safety and Tolerability of OXC XR as Adjunctive Therapy in Subjects With Refractory Partial Epilepsy

NCT ID: NCT00908349

Last Updated: 2017-05-31

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

214 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-06-30

Study Completion Date

2011-11-30

Brief Summary

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Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Oxcarbazepine Extended-Release (OXC XR)

Detailed Description

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NAP

Conditions

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Partial Epilepsy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Oxcarbazepine XR

Open Label Study

Group Type OTHER

Oxcarbazepine XR

Intervention Type DRUG

Open Label Study

Interventions

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Oxcarbazepine XR

Open Label Study

Intervention Type DRUG

Other Intervention Names

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SPN-804O

Eligibility Criteria

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Inclusion Criteria

1. Able to provide written informed consent and agree to comply with study procedures.
2. Male or female aged 18 to 66 years, inclusive.
3. Successful completion of the 804P301 study.
4. Sexually active women, unless surgically sterile (at least 6 months prior to Study Medication \[SM\] administration) or at least 1 year post-menopausal, must use an effective method of avoiding pregnancy (including oral, transdermal, or implanted contraceptives \[any hormonal method in conjunction with a secondary method\], intrauterine device, female condom with spermicide, diaphragm with spermicide, cervical cap, abstinence, use of condom with spermicide by sexual partner or sterile \[at least 6 months prior to SM administration\] sexual partner) for at least four weeks prior to SM administration, and must agree to continue using such precautions through the End of Study visit. Cessation of birth control after this point should be discussed with a responsible physician.

Exclusion Criteria

1. Clinically significant change in health status that, in the opinion of the Investigator, would prevent the subject from participating in this study or successfully completing this study.
2. Any reason which, in the opinion of the Investigator, would prevent the subject from participating in the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

66 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Supernus Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Janet K Johnson, PhD

Role: STUDY_DIRECTOR

Supernus Pharmaceuticals, Inc.

Locations

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Huntsville, Alabama, United States

Site Status

Northport, Alabama, United States

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Little Rock, Arkansas, United States

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Riverside, California, United States

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West Los Angeles, California, United States

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Aurora, Colorado, United States

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Jacksonville, Florida, United States

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Miami, Florida, United States

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Sarasota, Florida, United States

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Springfield, Illinois, United States

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Lexington, Kentucky, United States

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Bethesda, Maryland, United States

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Missoula, Montana, United States

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New York, New York, United States

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Oklahoma City, Oklahoma, United States

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Nashville, Tennessee, United States

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Baytown, Texas, United States

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Temple, Texas, United States

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Blagoevgrad, , Bulgaria

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Pleven, , Bulgaria

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Rousse, , Bulgaria

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Sofia, , Bulgaria

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Varna, , Bulgaria

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Calgary, Alberta, Canada

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Greenfield Park, Quebec, Canada

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Dubrovnik, , Croatia

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Zagreb, , Croatia

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Col. Las Palmas, Chihuahua, Mexico

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Col. Guillermina, Durango, Mexico

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Guadalajara, Jalisco, Mexico

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Zapopan, Jalisco, Mexico

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Mexico City, Mexico City, Mexico

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San Luis Potosí City, San Luis Potosí, Mexico

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Aguascalientes, , Mexico

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Puebla City, , Mexico

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Giżycko, , Poland

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Katowice, , Poland

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Krakow, , Poland

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Lodz, , Poland

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Lublin, , Poland

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Warsaw, , Poland

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Wilkowice, , Poland

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Bucharest, , Romania

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Campulung Muscel, , Romania

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Cluj-Napoca, , Romania

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Craiova, , Romania

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Kazan', , Russia

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Kirov, , Russia

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Kursk, , Russia

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Moscow, , Russia

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Nizhny Novgorod, , Russia

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Novosibirsk, , Russia

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Pyatigorsk, , Russia

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Saint Petersburg, , Russia

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Samara, , Russia

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Smolensk, , Russia

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Countries

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United States Bulgaria Canada Croatia Mexico Poland Romania Russia

Other Identifiers

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804P302

Identifier Type: -

Identifier Source: org_study_id

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