Study of a Polymorphism in Patients With Prostate Cancer
NCT ID: NCT00900185
Last Updated: 2015-04-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
750 participants
OBSERVATIONAL
Brief Summary
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PURPOSE: This laboratory study is looking at blood samples from patients with prostate cancer and from healthy participants to identify a polymorphism that may help in the study of prostate cancer.
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Detailed Description
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Primary
* Determine the incidence of the D104N COL18A1 polymorphism in patients with prostate cancer.
Secondary
* Determine the incidence of this polymorphism in African-American patients with prostate cancer.
OUTLINE: This is a retrospective, multicenter study.
DNA is extracted from preexisting serum samples and polymerase chain reaction is performed to determine the genotype pattern.
PROJECTED ACCRUAL: A total of 500 patients and 250 healthy participants will be accrued for this study.
Conditions
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Interventions
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mutation analysis
polymerase chain reaction
polymorphism analysis
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of prostate cancer OR healthy participant
* Patient enrolled on an IRB-approved clinical trial at the National Cancer Institute or Northwestern University, including, but not limited to, any of the following:
* NCI-99-C-0052
* NCI-95-C-0178
* NCI-00-C-003
* NCI-00-C-0080
PATIENT CHARACTERISTICS:
* Not specified
PRIOR CONCURRENT THERAPY:
* Not specified
MALE
Yes
Sponsors
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National Cancer Institute (NCI)
NIH
Principal Investigators
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William D. Figg, PharmD
Role: STUDY_CHAIR
National Cancer Institute (NCI)
References
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Macpherson GR, Singh AS, Bennett CL, Venzon DJ, Liewehr DJ, Franks ME, Dahut WL, Kantoff PW, Price DK, Figg WD. Genotyping and functional analysis of the D104N variant of human endostatin. Cancer Biol Ther. 2004 Dec;3(12):1298-303. doi: 10.4161/cbt.3.12.1453. Epub 2004 Dec 16.
Price DK, Macpherson GR, Dahut W, et al.: A mutation in COL18A1 and the association with prostate cancer. [Abstract] American Association for Cancer Research: 94th Annual Meeting, 11-14th July 2003, Washington, D.C. 44: A-4054, 810, 2003.
Other Identifiers
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NCI-03-C-0153
Identifier Type: -
Identifier Source: secondary_id
NU-98U2
Identifier Type: -
Identifier Source: secondary_id
CDR0000304552
Identifier Type: -
Identifier Source: org_study_id
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