PRostate Cancer Individual Signature Evaluation Trial in Patients Undergoing Scheduled Prostate Biopsy

NCT ID: NCT00966095

Last Updated: 2010-11-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-12-31

Brief Summary

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The purpose of this study is to develop and validate a blood-based diagnostic test that will predict prostate biopsy outcome as positive or negative for prostate cancer. Such a test will serve to reduce the number of unnecessary prostate biopsies.

Detailed Description

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Conditions

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Prostate Cancer

Keywords

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prostate cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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men scheduled for prostate biopsy

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Male over the age of 40.
2. Patient is scheduled for prostate biopsy for one or more of the following reasons:

* PSA \> 2.5 ng/ml
* Rising PSA (\>0.5 ng/ml/yr)
* Lower PSA value with other risk factors for prostate cancer (e.g.; family history)
* Abnormal DRE
* Percent free PSA \<15%
3. No prior history of prostate cancer or prostate biopsy.

Exclusion Criteria

* Unable or unwilling to provide informed consent
Minimum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Source MDx

INDUSTRY

Sponsor Role lead

Responsible Party

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Source MDx

Principal Investigators

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William Oh, MD

Role: PRINCIPAL_INVESTIGATOR

Mt. Sinai School of Medicine

Danute "Bunki" Bankaitis-Davis, PhD

Role: PRINCIPAL_INVESTIGATOR

Source MDx

Lisa Siconolfi, PhD

Role: PRINCIPAL_INVESTIGATOR

Source MDx

Philip Kantoff, MD

Role: PRINCIPAL_INVESTIGATOR

Dana-Farber Cancer Institute

Locations

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San Bernardino Urological Associates

San Bernardino, California, United States

Site Status

The Urology Center of Colorado

Denver, Colorado, United States

Site Status

University of Chicago Medical Center

Chicago, Illinois, United States

Site Status

Johns Hopkins University Brady Urological Institute

Baltimore, Maryland, United States

Site Status

Brigham and Women's Hospital/ Dana Farber Cancer Institute

Boston, Massachusetts, United States

Site Status

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Site Status

Bay State Clinical Trials

Watertown, Massachusetts, United States

Site Status

University of Michigan

Ann Arbor, Michigan, United States

Site Status

Karmanos Cancer Institute Wayne State University

Detroit, Michigan, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

University Urology Associates

New York, New York, United States

Site Status

Mount Sinai Medical Center

New York, New York, United States

Site Status

Durham VA Medical Center

Durham, North Carolina, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Urology Clinics of North Texas

Dallas, Texas, United States

Site Status

Urology San Antonio Research

San Antonio, Texas, United States

Site Status

University of Washington Department of Urology

Seattle, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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PReCISE

Identifier Type: -

Identifier Source: org_study_id