Hepatic Mitochondrial Function in Sepsis

NCT ID: NCT00889083

Last Updated: 2020-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2009-04-30

Study Completion Date

2012-04-30

Brief Summary

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Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome.

The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.

Detailed Description

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Conditions

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Sepsis Peritonitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Control

Non septic patients needing hepatic surgery

No interventions assigned to this group

Sepsis

Septic patients needing surgery for peritonitis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Septic group : Peritonitis patients needing surgery
* Non septic group : Patients needing hepatic surgery

Exclusion Criteria

* No liver biopsy performed
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Professor C ICHAI

OTHER

Sponsor Role lead

Responsible Party

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Professor C ICHAI

Professor Chair of IAAM

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Carole Ichai, MD, PhD

Role: STUDY_CHAIR

Centre Hospitalier Universitaire de Nice

Locations

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CHU de Nice

Nice, , France

Site Status

Countries

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France

References

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Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet. 2002 Jul 20;360(9328):219-23. doi: 10.1016/S0140-6736(02)09459-X.

Reference Type BACKGROUND
PMID: 12133657 (View on PubMed)

Fredriksson K, Hammarqvist F, Strigard K, Hultenby K, Ljungqvist O, Wernerman J, Rooyackers O. Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1044-50. doi: 10.1152/ajpendo.00218.2006. Epub 2006 Jun 27.

Reference Type BACKGROUND
PMID: 16803854 (View on PubMed)

Other Identifiers

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IAAM-2009-1

Identifier Type: -

Identifier Source: org_study_id

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