Protocol to Obtain Blood Samples for Leukemia Research

NCT ID: NCT00889031

Last Updated: 2020-04-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

187 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-04-30

Study Completion Date

2018-03-09

Brief Summary

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The purpose of this study is to collect a blood sample in patients with Chronic Lymphocytic Leukemia (CLL).

Detailed Description

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The blood sample will be used in the laboratory to perform studies focusing on Chronic Lymphocytic Leukemia (CLL).

Conditions

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Chronic Lymphocytic Leukemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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No Treatment

No Intervention

Intervention Type OTHER

Patients with Chronic Lymphocytic Leukemia (CLL)

Interventions

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No Intervention

Patients with Chronic Lymphocytic Leukemia (CLL)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing routine blood draws as part of their ongoing follow-up for Chronic Lymphocytic Leukemia (CLL) at the Norris Cotton Cancer Center of DHMC.

Exclusion Criteria

* Patients who have received cytotoxic drug, oral or intravenous steroid or targeted antibody therapy for CLL or other disease process within the past 6 months are excluded. Use of intravenous immunoglobulin (IVIg) is not a reason for exclusion.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dartmouth-Hitchcock Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Christopher H. Lowrey

Professor of Medicine and of Pharmacology and Toxicology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Christopher H Lowrey, MD

Role: PRINCIPAL_INVESTIGATOR

Dartmouth-Hitchcock Medical Center

Locations

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Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States

Site Status

Countries

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United States

References

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Stadheim TA, Xiao H, Eastman A. Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells. Cancer Res. 2001 Feb 15;61(4):1533-40.

Reference Type BACKGROUND
PMID: 11245462 (View on PubMed)

Vilpo JA, Koski T, Vilpo LM. Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro. Eur J Haematol. 2000 Dec;65(6):370-8. doi: 10.1034/j.1600-0609.2000.065006370.x.

Reference Type BACKGROUND
PMID: 11168494 (View on PubMed)

Kivekas I, Vilpo L, Vilpo J. Relationships of in vitro sensitivities tested with nine drugs and two types of irradiation in chronic lymphocytic leukemia. Leuk Res. 2002 Nov;26(11):1035-41. doi: 10.1016/s0145-2126(02)00050-4.

Reference Type BACKGROUND
PMID: 12363473 (View on PubMed)

Other Identifiers

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D0905

Identifier Type: -

Identifier Source: org_study_id

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