Analysis of Genetic Factors Related to Predisposition and Prognosis of Hematological Malignancies in Israel

NCT ID: NCT00159003

Last Updated: 2017-08-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

1998-01-01

Study Completion Date

2017-07-01

Brief Summary

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There are naturally occuring variations in the genetic makeup of all of us. Some of these variations may contribute to a change in susceptibility toward different diseases or change the prognosis.

We are studying these genetic variations in patients with leukemia. The genes we are studying are those which influence detoxification of drugs and toxins.

Detailed Description

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We have prepared DNA on patients with leukemia (AML, CML and CLL) and we are studying the influence of polymorphisms in drug metabolism and disposition genes on predisposition and prognosis of these types of leukemia. The genes we are studying include: MDR1, CYP3A4, NQO1, NAT1/2, GST, hOCT. We plan to study other genes that may be contributory.

Study includes comparing the frequency of polymorphisms in these genes with the frequency in the general population and the study of DNA biding proteins which bind at the sites of these polymorphisms.

Conditions

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Acute Myeloid Leukemia Chronic Lymphocytic Leukemia Chronic Myelogenous Leukemia

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* diagnosis of acute myeloid leukemia or chronic lymphocytic leukemia

Exclusion Criteria

* under 18 years of age
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Deborah Rund

OTHER

Sponsor Role lead

Responsible Party

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Deborah Rund

Senior Hematologist

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Deborah G Rund, MD

Role: PRINCIPAL_INVESTIGATOR

Hadassah Medical Organization

Locations

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Hadassah Medical Organization

Jerusalem, , Israel

Site Status

Countries

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Israel

References

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Chanock S. Genetic variation and hematology: single-nucleotide polymorphisms, haplotypes, and complex disease. Semin Hematol. 2003 Oct;40(4):321-8. doi: 10.1016/s0037-1963(03)00198-7.

Reference Type BACKGROUND
PMID: 14582082 (View on PubMed)

Other Identifiers

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132910-HMO-CTIL

Identifier Type: -

Identifier Source: org_study_id

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