An Open-label, Randomized, 3-period Crossover Study to Evaluate Sumatriptan Pharmacokinetics for a TREXIMA™ (Sumatriptan Succinate / Naproxen Sodium) Tablet Followed by IMITREX® (Sumatriptan Succinate)

NCT ID: NCT00875784

Last Updated: 2017-08-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2008-05-06
• Study Completion Date: 2008-06-14

Brief Summary

This study will evaluate the exposure of sumatriptan after administration of TREXIMA (sumatriptan 85mg/naproxen sodium 500mg) followed by a subcutaneous IMITREX injection (4mg or 6mg) 2 hours later compared to administration of a IMITREX 100mg tablet followed by a IMITREX 100mg tablet 2 hours later.

Detailed Description

An open-label, randomized, 3-period crossover study to evaluate sumatriptan pharmacokinetics for a TREXIMA™ (sumatriptan succinate / naproxen sodium) Tablet followed by IMITREX® (sumatriptan succinate) Injection 4mg administered using the IMITREX STATdose System® and a TREXIMA tablet followed by IMITREX® (sumatriptan succinate) Injection 6mg administered using the IMITREX STATdose System® compared with an IMITREX Tablet 100mg followed by an IMITREX Tablet 100mg.

Conditions

Migraine Disorders

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

TREXIMA tablet followed by IMITREX injection (4mg)

TREXIMA™ (sumatriptan succinate / naproxen sodium) Tablet followed by IMITREX® (sumatriptan succinate) Injection 4mg administered using the IMITREX STATdose System®

Group Type: EXPERIMENTAL

TREXIMA™

Intervention Type: DRUG

sumatriptan succinate / naproxen sodium tablet

IMITREX® (4mg)

Intervention Type: DRUG

sumatriptan succinate injection (4mg) administered using the IMITREX STATdose System®

TREXIMA tablet followed by IMITREX injection (6mg)

TREXIMA tablet followed by IMITREX® (sumatriptan succinate) Injection 6mg administered using the IMITREX STATdose System®

Group Type: EXPERIMENTAL

TREXIMA™

Intervention Type: DRUG

sumatriptan succinate / naproxen sodium tablet

IMITREX® (6mg)

Intervention Type: DRUG

sumatriptan succinate injection (6mg) administered using the IMITREX STATdose System®

IMITREX tablet (100mg)

IMITREX 100mg tablet followed 2 hours later by a second IMITREX 100mg tablet

Group Type: ACTIVE_COMPARATOR

IMITREX Tablet 100mg

Intervention Type: DRUG

IMITREX 100mg tablet followed 2 hours later by a second IMITREX 100mg tablet

Interventions

TREXIMA™

sumatriptan succinate / naproxen sodium tablet

Intervention Type: DRUG

IMITREX® (4mg)

sumatriptan succinate injection (4mg) administered using the IMITREX STATdose System®

Intervention Type: DRUG

IMITREX® (6mg)

sumatriptan succinate injection (6mg) administered using the IMITREX STATdose System®

Intervention Type: DRUG

IMITREX Tablet 100mg

IMITREX 100mg tablet followed 2 hours later by a second IMITREX 100mg tablet

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Healthy adult males and females between 18 and 55 years of age, inclusive. Healthy subjects are defined as individuals who are free from clinically significant illness or disease as determined by their medical history, physical examination, laboratory studies and other tests.
• Female subjects of non-childbearing potential
• Any subject taking oral contraceptives has been on a stable regimen for at least 2 months prior to screening.
• BMI: 20-30 kg/m2, inclusive.
• Subject is willing and able to provide written informed consent.

Exclusion Criteria

• Subjects who suffer from migraine attacks.
• Subject has confirmed or suspected ischemic heart disease; angina pectoris, history of myocardial infarction, documented silent ischemia, Prinzmetal's angina-coronary vasospasm, signs, or symptoms consistent with any of the above.
• Subject has evidence or history of ischemic abdominal syndromes, peripheral vascular disease or Raynaud's syndrome.
• Subject has cardiac arrhythmias requiring medication or a history of a clinically significant electrocardiogram abnormality that, in the investigator's opinion, contraindicates participation in this study.
• Subject has a history of cerebrovascular pathology including stroke and/or transient ischemic attacks.
• Subject has a history of congenital heart disease.
• Subject has hypertension at screening.
• Subject, in the investigator's opinion, is likely to have unrecognized cardiovascular or cerebrovascular disease.
• Subject has a history of epilepsy or structural brain lesions which lower the convulsive threshold or treated with an antiepileptic drug for seizure control within 5 years prior to screening.
• History of impaired hepatic or renal function.
• Subject is currently taking or has taken in the previous 4 weeks, herbal preparations containing St. John's Wort.
• Use of other prescription or non-prescription drugs, vitamins, herbal and dietary supplements, within 7 days prior to the first dose of study medication.

Note: Excluded from this list are: acetaminophen at doses of less than or equal to 2 grams per day and contraceptives.

• Subject has a hypersensitivity, intolerance, or contraindication to the use of sumatriptan or naproxen sodium or any of their components or any other 5-HT1 receptor agonist.
• Subject has a history of any gastrointestinal surgery that specifically indicates a past history of bleeding, ulceration or perforation.
• Subject has a history of gastric bypass or stapling surgery.
• Subject has a history of GI ulceration in the past six months or gastrointestinal bleeding in the past year.
• Subject has a history of inflammatory bowel disease.
• Treatment with an investigational drug within 30 preceding the first dose of study medication.
• Positive serum beta-human chorionic gonadotropin test -females.
• Pregnant, actively trying to become pregnant or breast-feeding.
• Subjects with a history of drug or alcohol abuse.
• History of regular alcohol consumption exceeding 7 drinks per week for females or 14 drinks per week for men within 6 months of screening.
• Positive urine drug screen including alcohol at screening.
• Donation of blood in excess of 500 mL within 56 days prior to first dose of study medication.
• Subjects who smoke more than 10 cigarettes per day.
• History of sensitivity to heparin, heparin-induced thrombocytopenia or sensitivity to any of the study medications or components thereof.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

GlaxoSmithKline

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

GSK Investigational Site

Tacoma, Washington, United States

Countries

United States

References

Berges A, Walls C, Lener SE, McDonald SA. Pharmacokinetics and tolerability of sumatriptan after single-dose administration of a fixed-dose combination tablet of sumatriptan/naproxen sodium 85/500 mg followed two hours later by subcutaneous sumatriptan 4- or 6-mg injection: a randomized, open-label, three-period crossover study in healthy volunteers. Clin Ther. 2010 Jun;32(6):1165-77. doi: 10.1016/j.clinthera.2010.06.014.

Reference Type: DERIVED

PMID: 20637969 (View on PubMed)

Study Documents

Document Type: Dataset Specification

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Study Protocol

For additional information about this study please refer to the GSK Clinical Study Register

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Document Type: Annotated Case Report Form

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Individual Participant Data Set

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Clinical Study Report

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Informed Consent Form

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Statistical Analysis Plan

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Related Links

https://www.clinicalstudydatarequest.com

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Other Identifiers

103629

Identifier Type: -

Identifier Source: org_study_id