Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer
NCT ID: NCT00874406
Last Updated: 2009-04-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
100 participants
INTERVENTIONAL
2008-01-31
2009-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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1
transhepatic arterial chemotherapy (TAC) were given 7 days before liver metastasis resection. Adjuvant folfox4 chemotherapy was done within 28 days after surgery.
tac + folfox4
tac: oxaliplatin 100mg + fudr 1g + mmc 10mg 7 days later： operation within 28 days after operation: folfox4
2
Liver metastasis resection was done without TAC. Adjuvant folfox4 chemotherapy was done within 28 days after surgery.
folfox4
folfox4 will be done within 28 days after liver resection
Interventions
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tac + folfox4
tac: oxaliplatin 100mg + fudr 1g + mmc 10mg 7 days later： operation within 28 days after operation: folfox4
folfox4
folfox4 will be done within 28 days after liver resection
Eligibility Criteria
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Inclusion Criteria
* resectable liver metastasis
* remnant liver volume \>= 70%
* without other organ metastasis or peritoneum metastasis
* without contradiction of cardiac and pulmonary diseases
Exclusion Criteria
* unresectable liver metastasis
* remnant liver volume \< 50%
* with other organ metastasis or peritoneum metastasis
* with contradiction of cardiac and pulmonary diseases
18 Years
75 Years
ALL
No
Sponsors
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Fudan University
OTHER
Responsible Party
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Zhongshan hospital, Fudan University
Principal Investigators
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jianmin xu, MD, PHD
Role: PRINCIPAL_INVESTIGATOR
department of general surgery, zhongshan hospital, fudan university
Locations
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Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2009-04
Identifier Type: -
Identifier Source: org_study_id
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