A Polymerase Chain Reaction (PCR) - Based Method to Improve Antibiotic Prescribing for Pneumonia

NCT ID: NCT00867841

Last Updated: 2016-02-25

Basic Information

• Recruitment Status: WITHDRAWN
• Study Classification: OBSERVATIONAL

Brief Summary

Pneumonia, or lung infection, is usually treated with antibiotics targeted against the organisms that the physician guesses are causing the problem. The determination of the exact cause of a patient's pneumonia is difficult. The problem is that the two major causes of community-acquired pneumonia are not easily distinguished on clinical grounds and are best treated by different antibiotics. The investigators hypothesize that antibiotic therapy can be targeted and improved by doing polymerase chain reaction (PCR) testing of nose swabs to identify probable implicated organisms and their antibiotic resistance patterns. This pilot study will be important to ensure that the laboratory testing is functional and that the emergency department-laboratory communication is optimal prior to doing a full-fledged randomized clinical trial.

Conditions

Pneumonia

Study Design

• Observational Model Type: ECOLOGIC_OR_COMMUNITY
• Study Time Perspective: PROSPECTIVE

Study Groups

Pneumonia

Children diagnosed with community-acquired pneumonia by the emergency department physician

nasopharyngeal swab

Intervention Type: PROCEDURE

PCR of NP swab for Mycoplasma, Chlamydophila, pneumococcus, pneumococcus macrolide resistance genes.

Interventions

nasopharyngeal swab

PCR of NP swab for Mycoplasma, Chlamydophila, pneumococcus, pneumococcus macrolide resistance genes.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• presumed community-acquired pneumonia as diagnosed by the attending emergency department physician

Exclusion Criteria

• age > 6 months
• immunodeficiency (primary, advanced HIV)
• cystic fibrosis
• malignancy
• known cardiac or lung defects
• bronchiectasis
• previous pneumonia or lung abscess in past 6 months
• conditions requiring treatment with immune suppressants

• Minimum Eligible Age: 180 Days
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

The Physicians' Services Incorporated Foundation

OTHER

Sponsor Role: collaborator

Children's Hospital of Eastern Ontario

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jeffrey Pernica, MD

Role: PRINCIPAL_INVESTIGATOR

Children's Hospital of Eastern Ontario/University of Ottawa

Robert Slinger, MD

Role: STUDY_DIRECTOR

Children's Hospital of Eastern Ontario/University of Ottawa

Locations

Children's Hospital of Eastern Ontario

Ottawa, Ontario, Canada

Countries

Canada

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Other Identifiers

CHEO-ID-001

Identifier Type: -

Identifier Source: org_study_id