The Influence of Probiotics in a Drinkable Yogurt on Skin Health
NCT ID: NCT00864188
Last Updated: 2013-05-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE1
207 participants
INTERVENTIONAL
2009-02-28
2010-04-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Two Supplemented Against Skin Reactivity
NCT01368224
Study to Investigate the Potential of Probiotics in Yogurt
NCT00492583
Evaluation of Skin Hydration in Adults With Dry Skin Using a Moisturizer With an Added Sterilized Probiotic
NCT05013645
Facial Skin Clinical and Microbial Profiling From Oral Probiotic Supplementation
NCT05597254
Effects of Lactobacillus Delbruckii Lactis DN111244 Fermented Milk Consumption on Plasma Lipids Levels in Hypercholesterolaemic Adults
NCT01353820
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
It will consist of five groups(40 subjects/group). The first group (1) of subjects will receive acidified milk that does not contain bacterial strains. The second group (2) will receive acidified milk that contains one specific probiotic strain. The third group (3) will receive fermented milk that contains a standard mix of yogurt bacterial strains. The fourth group (4) will receive fermented milk, containing the same standard mix of yogurt bacterial strains as in group 3 plus the same specific probiotic strain as in group 2. Finally, the fifth group (5) will receive fermented milk, containing the same standard mix of yogurt bacterial strains as in group 3 and 4 plus the same specific probiotic strain as in group 2 and 4 plus a mix of antioxidants.
This study will address whether:
A.The bioefficacy of a specific probiotic strain is influenced by a milk matrix.
B.Whether other bacterial strains impact the bioefficacy of this specific probiotic strain, and validate whether or not the bioefficacy is related entirely to the activity of this specific probiotic strain.
C.Whether nutritional supplements impact the bioefficacy of a specific probiotic strain.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
3
Fermented milk containing two standard bacterial strains for acidification - Streptococcus thermophilus and Lactobacillus delbrueckii subsp.bulgaricus.
Two standard yogurt fermenting bacterial strains - Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus
Fermented milk containing two standard yogurt bacterial strains.
4
Fermented milk containing two standard bacterial strains for acidification - Streptococcus thermophilus and Lactobacillus delbrueckii and one probiotic strain called Lactobacillus paracasei NCC2461.
One probiotic strain - Lactobacillus paracasei NCC2461
Glucono-Delta-Lactone acidified or fermented milk containing one probiotic strain.
Two standard yogurt fermenting bacterial strains - Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus
Fermented milk containing two standard yogurt bacterial strains.
5
Fermented milk containing two standard bacterial strains for acidification - Streptococcus thermophilus and Lactobacillus delbrueckii, one probiotic strain called Lactobacillus paracasei NCC2461 and Vitamin B2,B3, C and E, Beta Carotene and an Oil.
One probiotic strain - Lactobacillus paracasei NCC2461
Glucono-Delta-Lactone acidified or fermented milk containing one probiotic strain.
Two standard yogurt fermenting bacterial strains - Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus
Fermented milk containing two standard yogurt bacterial strains.
Vit B2, B3, C and E, Beta Carotene and Oil
Fermented milk containing nutritional supplements
1
Glucono-Delta-Lactone acidified milk containing no bacterial strains
no bacterial strains
Glucono-Delta-Lactone acidified milk containing no bacterial strains
2
Glucono-Delta-Lactone acidified milk containing one probiotic strain called Lactobacillus paracasei NCC2461.
One probiotic strain - Lactobacillus paracasei NCC2461
Glucono-Delta-Lactone acidified or fermented milk containing one probiotic strain.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
no bacterial strains
Glucono-Delta-Lactone acidified milk containing no bacterial strains
One probiotic strain - Lactobacillus paracasei NCC2461
Glucono-Delta-Lactone acidified or fermented milk containing one probiotic strain.
Two standard yogurt fermenting bacterial strains - Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus
Fermented milk containing two standard yogurt bacterial strains.
Vit B2, B3, C and E, Beta Carotene and Oil
Fermented milk containing nutritional supplements
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Caucasian
* Age: 25-55 y (inclusive)
* Normal BMI ≤ 30
* Skin type 1-111
* Regular Hormonal Cycle
* Having given his/her written informed consent
* Willing to avoid the consumption of fermented dairy products
* Minimum consumption of dark chocolate during the period of the study
Exclusion Criteria
* Pregnant or lactating women
* Post menopausal women
* Heavy alcohol intake (usually consuming more than 3 standard drinks/day)
* Intake of chronic medications except oral contraceptive
* Vitamin and/or mineral and/or antioxidant supplementation over the 3 months preceding the initiation of the study and throughout the study.
* Having skin cancer or genetic disposition to skin cancer
* Regular exposure to artificial UVR
* Daily exposure to sun more than one week over the 2 months preceding the initiation of the study
* Planned vacation to sun during the period of the study.
* Excessive tea drinkers (more than 2 cups a day of green or black tea).
* Excessive consumer of fermented dairy products (more than 150g per day).
* Excessive consumer of dark chocolate (\> 25g per day).
* Regular high exercise such as a marathon
* Subject who regularly takes saunas (dry or wet) or swims daily.
* Subject who cannot be expected to comply with treatment
* Currently participating or having participated in another interventional clinical trial during the last 3 months prior to the beginning of this study.
25 Years
55 Years
FEMALE
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Société des Produits Nestlé (SPN)
INDUSTRY
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Institut für umweltmedizinische Forschung (IUF) an der Heinrich-Heine-Universität Düsseldorf gGmbH
Düsseldorf, , Germany
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
08.29.NRC
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.