Efficacy and Long-Term Safety of Vildagliptin as Add-on Therapy to Metformin in Patients With Type 2 Diabetes

NCT ID: NCT00860288

Last Updated: 2020-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

1988 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-02-28

Study Completion Date

2011-03-31

Brief Summary

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This is a 2-3 period parallel group study with an adaptive element in Type 2 diabetes patients receiving vildagliptin as add-on therapy to metformin

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2

Keywords

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Type 2 Diabetes vildagliptin

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Vildagliptin Dose 1

Group Type EXPERIMENTAL

Vildagliptin

Intervention Type DRUG

Metformin

Intervention Type DRUG

Vildagliptin Dose 2

Group Type EXPERIMENTAL

Vildagliptin

Intervention Type DRUG

Metformin

Intervention Type DRUG

Placebo

Group Type PLACEBO_COMPARATOR

Metformin

Intervention Type DRUG

Placebo

Intervention Type DRUG

Sitagliptin

Group Type ACTIVE_COMPARATOR

Metformin

Intervention Type DRUG

Sitagliptin

Intervention Type DRUG

Interventions

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Vildagliptin

Intervention Type DRUG

Metformin

Intervention Type DRUG

Placebo

Intervention Type DRUG

Sitagliptin

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients 18-78 years old inclusive at Visit 1
* T2DM patients treated with metformin for at least 3 months and a stable dose of at least 1500 mg daily for a minimum of 4 weeks prior to Visit 1
* Patient agreement to maintain same dose of metformin throughout study
* HbA1c of ≥ 7.0 and ≤ 9.5 % at Visit 1
* Body Mass Index (BMI) in the range of 22-45 kg/m2 at visit 1

Exclusion Criteria

* Pregnant or nursing (lactating) women
* FPG ≥ 270 mg/dL ( ≥ 15.0 mmol/L)
Minimum Eligible Age

18 Years

Maximum Eligible Age

78 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Instituto de Investigaciones Biomedicas

Buenos Aires, Santa Fe Province, Argentina

Site Status

Grupo Colaborative Rosario

Rosario, Santa Fe Province, Argentina

Site Status

Grupo Medico Alem

Buenos Aires, , Argentina

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DIM Clinical Privada

Buenos Aires, , Argentina

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Clinica Medica Sin Internacion

Buenos Aires, , Argentina

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Fundación de Estudios Farmacológicos y de Medicamentos

Buenos Aires, , Argentina

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Universitaetsklinik Graz medizinische Universitaetsklinik;

Graz, , Austria

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LKH Salzburg Landesklinik fuer Innere Medizin I

Salzburg, , Austria

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Millergasse 7

Vienna, , Austria

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Hanusch Krankenhaus 1. Med. Abteilung und Nephrodepartment

Vienna, , Austria

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Kindlergasse 4

Wiener Neustadt, , Austria

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Kindlergasse 4

Wiener Neustadt, , Austria

Site Status

Private Practice Diabetology (Dr. Coucke)

Sint-Gillis-Waas, Sint-Niklaasstraat 117, Belgium

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Private Practice Cardiology (Dr. Hollanders)

De Pinte, , Belgium

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Private Practice (Vernijns)

Genk, , Belgium

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Private Practice (Dr. De Meulemeester)

Gozée, , Belgium

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Huisartsenpraktijk Hygeia

Hasselt, , Belgium

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Private Practice (Dr. Jaak Mortelmans)

Oostham, , Belgium

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Lihavuustutkimusyksikkö

Helsinki, , Finland

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Mehiläinen Töölö Diabetesklinikka

Helsinki, , Finland

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Terveystalo Kuopio

Kuopio, , Finland

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Mehiläinen Lahti

Lahti, , Finland

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ODL Terveys Oy, Tutkimusyksikkö,

Oulu, , Finland

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Mehiläinen Riihimäki

Riihimäki, , Finland

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Terveystalo Tampereen työterveys Kalmar

Tampere, , Finland

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Myyrmäen terveysasema

Vantaa, , Finland

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Internistische Gemeinschaftspraxis Nagel, Dietlein & Hunstiger

Augsburg, , Germany

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Praxis Dr. Med. Kurt Rack

Augsburg, , Germany

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Gemeinschaftspraxis S. Maxeiner/Dr. Behr/S. Rupprecht

Bad Kreuznach, , Germany

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Klinische Forschung Berlin-Buch

Berlin, , Germany

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Praxis Dr. Med. Ulrike Venschott-Jordan

Berlin, , Germany

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Praxis Dr. Med. Monika Kiper

Berlin, , Germany

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Praxis Dr. Med. Christina Bondke

Berlin, , Germany

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Bibertal Klinik

Bibertal, , Germany

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Praxis Dr. Med. Claudia Ulbrich

Cologne, , Germany

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Gemeinschaftspraxis Dr. med. Ali Boustani

Diez, , Germany

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Facharzt fuer Allgemeinmedizin

Dorsten, , Germany

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Praxis Dr. Med. Anwar Ansari

Einbeck, , Germany

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Hausaerzte am Stern Dr. Med. Blume / Dr. Med. Garanin

Essen, , Germany

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Praxis Dr. Med. Roland Kutzke

Essen, , Germany

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Praxis Dr. Med. Thorsten Rau

Essen, , Germany

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Praxis Dr. Med. Joerg Luedemann / Facharzt fuer Innere Medizin - Diabetologie

Falkensee, , Germany

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Praxis Dr. Med. Daniela Freise

Frankfurt, , Germany

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Dial.-Med. Kerstin Steinbach

Freital, , Germany

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Gemeinschaftspraxis

Fulda, , Germany

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Praxis Dr. Med. Wolfgang Krause

Grimma, , Germany

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Krankenhaus Hagenow, Innere Medizin

Hagenow, , Germany

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MVZ-medicum Hamburg

Hamburg, , Germany

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Diabetes-Zentrum Wandsbek

Hamburg, , Germany

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Gemeinschaftspraxis Dr. Grüneberg, Dr.Mehring, Bitterer-Tölle

Herne, , Germany

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Praxis Dr. Med. Helmut Anderten

Hildesheim, , Germany

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Praxis Dr. Med. Juergen Landschulze

Kahla, , Germany

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Praxis Dr. Med. Julia Chevts

Karlsruhe, , Germany

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Praxis Dr. Med. Hans-Helmut Seibert

Kassel, , Germany

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Dres. Klein/Minnich

Künzing, , Germany

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Praxis Dr. Med. Birgit Hoene

Leipzig, , Germany

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Pro Scientia med

Lübeck, , Germany

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Diabetes Schwerpunktpraxis

Meissen, , Germany

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Praxis Dres. Prohaska / Lindner

Mühldorf, , Germany

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Praxis Dr. Med. Claus-Michael Grimm

München, , Germany

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Praxis Dr. Fischer & Dr. Keuthage

Münster, , Germany

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Gemeinschaftspraxis Dr. Uwe Böckmann/Dr. med. Maren Molkewehrum

Neumünster, , Germany

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Praxis Dr. Med. Joachim Etter

Oberhausen, , Germany

Site Status

IkFE Studiencenter Potsdam GMBH i.G.

Potsdam, , Germany

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Diabetes Center Quakenbrueck

Quakenbrück, , Germany

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Praxis Dr. Altwicker, Dr. Kanis

Reinfeld, , Germany

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Praxis Dr. Med. Ulrich Aigner

Rothenburg, , Germany

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Praxis Dr. Med. Sabine Sedl

Schönberg, , Germany

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Dres. Hiltensperger & Schaal

Schrobenhausen, , Germany

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Praxis Hans-Joachim Herrmann/Dr. med. B. Bauer

Schwabenheim, , Germany

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Praxis Dr. Med. Ottmar Herfert

Stuttgart, , Germany

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Praxis Dr. Med. Doru Popa

Veitsbronn, , Germany

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Gemeinschaftspraxis Gerhard Steinmaier und Dr. Med. Werner Bauer

Viernheim, , Germany

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Gemeinschaftspraxis Sauter

Wangen, , Germany

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Praxis Dr. Med. Rudolf Matthias Remppis

Weißenhorn, , Germany

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Praxis Dr. Med. Peter Genthner

Welzheim, , Germany

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Gemeinschaftspraxis Dr. med. Reinhold Schneider und Christine Schneider

Wetzlar, , Germany

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Laiko General Hospital,

Athens, , Greece

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Lamia General Hospital

Larissa, , Greece

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Papageorgiou General Hospital

Thessaloniki, , Greece

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Clínica y Hospital Colón del Paciente Diabético

Guatemala City, , Guatemala

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Endonutri S.A

Guatemala City, , Guatemala

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Clínica y Hospital Colón del Paciente Diabético

Guatemala City, , Guatemala

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Clinica Dr. Erick Turcios

Guatemala City, , Guatemala

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Endonutri S. A.

Guatemala City, , Guatemala

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Clinica Dr. Sergio Bran

Guatemala City, , Guatemala

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Szent Margit Hospita

Budapest, , Hungary

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Károlyi Sándor Hospital

Budapest, , Hungary

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Szent Imre Hospital

Budapest, , Hungary

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Konszenzusplusz Kft.

Csongrád, , Hungary

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Petz Aladar Hospital

Győr, , Hungary

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Jósa Andras Hospital

Nyíregyháza, , Hungary

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Szte-Áok I

Szeged, , Hungary

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Balassa Janos Hospital

Szekszárd, , Hungary

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Zala Megyei Hospital

Zalaegerszeg, , Hungary

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Manipal Hospital,

Bangalore, Karantaka, India

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Health and Research Centre

Trivandrum, Kerala, India

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Diabetes Thyroid Hormone Research Institute Pvt Ltd.

Indore, Madhya Pradesh, India

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Madras Diabetes Research Foundation

Chennai, Tamil Nadu, India

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M. V. Hosp for Diabetes P. Ltd. 4,

Chennai, , India

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Medicity Hospital

Hyderabaad, , India

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Nizam's institute of medical sciences,

Hyderabaad, , India

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S. R. Kalla Memorial gastro and general hosp,

Jaipur, , India

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Christian Medical College,

Vellore, , India

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Maccabi Healthcare Services

Rishon LeZiyyon, , Israel

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Ziv Medical Center

Safed, , Israel

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U.O.C. di Diabetologia e Malattie Metaboliche

Arenzano, , Italy

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U.S.C. di Endocrinologia (Ingresso 13 - piano 2) Dip. di Medicina

Bergamo, , Italy

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U.O.C. Diabetologia Endocrinologia Dip. Medico

Campobasso, , Italy

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U.O. Medicina Generale

Casorate Primo, , Italy

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I Divisione Medicina

Catania, , Italy

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U.O. Malattie Metaboliche e Diabetologia

Chieri, , Italy

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U.O.C. di Medicina d'Urgenza e Pronto Soccorso

Cosenza, , Italy

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Servizio Diabetologia, SOD Cardiologia Geriatrica - D.A.I. del Cuore e dei Vasi

Florence, , Italy

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Centro Diabetologico Malattie Metaboliche

Mercato San Severino, , Italy

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Divisione Malattie Metaboliche e Diabetologia

Milan, , Italy

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S. Semplice Dip. di Endocrinologia e Diabetologia Dip. di Medicina Interna

Milan, , Italy

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U.O. Medicina II - Dip. Medicina Interna

Milan, , Italy

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Unità Cardio-Metabolica e Trials Clinici Dipartimento di Medicina Interna

Milan, , Italy

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U.O. Diabetologia

Olbia, , Italy

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Centro per l'Aterosclerosi Dip. di Medicina Interna

Roma, , Italy

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U.O. Endocrinologia e Diabetologia

Roma, , Italy

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U.O.C. di Diabetologia c/o AUSL ROMA B - Sede Territoriale

Roma, , Italy

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U.O.C. di Medicina Interna B - BMI02 Dip. Scienze Cliniche - II Clinica Medica

Roma, , Italy

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S. S. di Diabetologia Dip. Med. Interna e Malattie Metaboliche

Siena, , Italy

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S.C. Prevenzione-Riabilitazione Cardiologica presso ex-Dispensario

Vibo Valentia, , Italy

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Daugavpils Regional Hospital

Daugavpils, , Latvia

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Primary Health Centre of Jaunliepaja

Liepāja, , Latvia

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Private practice of endocrinology

Ogre, , Latvia

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Center of Endocrinology

Riga, , Latvia

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Riga Outpatient Clinic "Dziednieciba"

Riga, , Latvia

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Talsi Clinical Hospital

Talsi, , Latvia

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Endocrinology Department of Vidzemes Hospital

Valmiera, , Latvia

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JSC "Klinikiniai sprendimai"

Alytus, , Lithuania

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Kaunas District Hospital

Kaunas, , Lithuania

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Kaunas Silainiai Outpatient Clinic

Kaunas, , Lithuania

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Kaunas Medical University Hospital

Kaunas, , Lithuania

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Kaunas Dainavos Outpatient Clinic

Kaunas, , Lithuania

Site Status

Vilnius University Hospital Santariskiu Clinics

Vilnius, , Lithuania

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Private Endocrinology Clinic

Vilnius, , Lithuania

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Comité Bioetico para la Investigación Clínica S.C.

Mexico City, Durango, Mexico

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Unidad Metabolica y Cardiovascular S.C.

Cuernavaca, Morelos, Mexico

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Clínica Eugenio Sue

Mexico City, Polanco Chapultepec, Mexico

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Clínica de Diabetes de la Secretaria de Salud de Durango

Durango, , Mexico

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Arke Estudios Clinicos S.A. de C.V.

Mexico City, , Mexico

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Flattum legesenter

Hønefoss, , Norway

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Randesund Helsesenter

Kristiansand, , Norway

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Sinsenklinikken

Oslo, , Norway

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Oslo Universitetssykehus

Oslo, , Norway

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Hinnastrekanten legekontor

Stavanger, , Norway

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Vennesla legesenter

Vennesla, , Norway

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Clinica San Miguel

Arequipa, , Peru

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Clinica Geriatrica Militar

Lima, , Peru

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Clinica San Borja

Lima, , Peru

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Clinica Senor de los Milagros

Lima, , Peru

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Hospital Nacional Cayetano Heredia

Lima, , Peru

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Hospital Nacional Guillermo Almenara Irigoyen

Lima, , Peru

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Bydgoskie Centrum Diabetologii i Endokrynologii

Bydgoszcz, , Poland

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NZOZ "Specjalista" Sp z o. o.

Kutno, , Poland

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Oddzial Chorob Wewnetrznych

Mielec, , Poland

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Poradnia Lekarza Rodzinnego

Poznan, , Poland

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Poznański Ośrodek Medyczny "NOVAMED"

Poznan, , Poland

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CMI Cardiologie "Dr. Pop Calin Florin"

Baia Mare, , Romania

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"C. I. Parhon" Endocrinology Institute

Bucharest, , Romania

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Medical Centre "Sanatatea Ta" SRL

Bucharest, , Romania

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Medical Practice SRL

Oradea, , Romania

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Anamed SRL

Oradea, , Romania

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Emergency County Hospital Ploiesti

Ploieşti, , Romania

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Policlinica "Dr. Citu"

Timișoara, , Romania

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MEDISPEKTRUM s.r.o,

Bratislava, Slovak Republic, Slovakia

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.Interna klinika, FN J.A. Reimana

Prešov, Slovak Republic, Slovakia

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Diabetologicka ambulancia,

Bratislava, Slovakia Republic, Slovakia

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Diabetologicka ambulancia

Košice, Slovakia Republic, Slovakia

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Diabetologicka ambulancia,

Lučenec, Slovakia Republic, Slovakia

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NZZ Diabetologicka ambulancia

Nové Zámky, Slovakia Republic, Slovakia

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Diabetes centrum s.r.o

Trenčín, Slovakia Republic, Slovakia

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Diabetologicka ambulancia,

Žilina, Slovakia Republic, Slovakia

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Diametabol.s.r.o.,

Bratislava, , Slovakia

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MUDr. Margita Kiripolska s.r.o

Považská Bystrica, , Slovakia

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Eulji General Hospital

Seoul, , South Korea

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Kangbuk Samsung Medical center

Seoul, , South Korea

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Korea University Guro Hospital

Seoul, , South Korea

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The Catholic University of Korea Holy Family Hospital

Seoul, , South Korea

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Ajou university hospital

Suwon, , South Korea

Site Status

Ambulatorio Militar Tipo III Paramacay. Avenida Universidad. Sector Santa Ana. Naguanagua.

Valencia, Carabobo, Venezuela

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Hospital Militar Dr Carlos Arvelo. Final Av. José Angel Lamas. Servicio de Endocrinología.

Caracas, , Venezuela

Site Status

Hospital Dr Miguel Perez Carreño. Servicio de Endocrinología. Sotano.

Caracas, , Venezuela

Site Status

Countries

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Portugal Argentina Austria Belgium Finland Germany Greece Guatemala Hungary India Israel Italy Latvia Lithuania Mexico Norway Peru Poland Romania Slovakia South Korea Venezuela

Related Links

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https://www.novctrd.com/ctrdweb/trialresult/trialresults/pdf?trialResultId=5663

Results for CLAF237B2224 from the Novartis Clinical Trials website

Other Identifiers

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CLAF237B2224

Identifier Type: -

Identifier Source: org_study_id