Efficacy of Fixed Combination Therapy of Vildagliptin and Metformin Compared to the Individual Monotherapy Components in Drug Naive Patients With Type 2 Diabetes

NCT ID: NCT00382096

Last Updated: 2020-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1179 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-09-30

Study Completion Date

2008-06-03

Brief Summary

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The purpose of this study is to evaluate the efficacy and safety of a fixed combination of vildagliptin and metformin in lowering blood glucose in patients with type 2 diabetes

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2

Keywords

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Type 2 diabetes vildagliptin metformin hemoglobin A1c

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Vildagliptin + Metformin Dose 1

Group Type EXPERIMENTAL

Vildagliptin + Metformin

Intervention Type DRUG

Vildagliptin + Metformin Dose 2

Group Type EXPERIMENTAL

Vildagliptin + Metformin

Intervention Type DRUG

Vildagliptin

Group Type ACTIVE_COMPARATOR

Vildagliptin

Intervention Type DRUG

Metformin

Group Type ACTIVE_COMPARATOR

Metformin

Intervention Type DRUG

Interventions

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Vildagliptin

Intervention Type DRUG

Metformin

Intervention Type DRUG

Vildagliptin + Metformin

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female (non-fertile or of childbearing potential using a medically approved birth control method) patients with type 2 diabetes
* Diagnosis of T2DM for at least 4 weeks prior to study entry
* Age 18 - 78 years inclusive
* Body mass index (BMI) of 22 - 40 kg/m2
* HbA1c: 7.5 - 11% inclusive
* FPG \<270 mg/dL (15 mmol/L)

Exclusion Criteria

* Pregnant or lactating female
* A history of type 1 diabetes
* Evidence of significant diabetic complications
Minimum Eligible Age

18 Years

Maximum Eligible Age

78 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Novartis Pharmaceuticals

Locations

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Novartis Pharmaceuticals

East Hanover, New Jersey, United States

Site Status

Multiple Locations, , Germany

Site Status

Countries

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United States Germany

Related Links

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https://www.novctrd.com/ctrdweb/trialresult/trialresults/pdf?trialResultId=2650

Clinical Trial Results for CLMF237A2302 at Novartis Clinical Trials.com

Other Identifiers

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CLMF237A2302

Identifier Type: -

Identifier Source: org_study_id