Anemia Treatment for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy

NCT ID: NCT00858364

Last Updated: 2022-11-30

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

2549 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-07-17

Study Completion Date

2017-06-07

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a study in patients with chemotherapy induced anemia receiving multi-cycle chemotherapy for the treatment of stage IV non-small cell lung cancer (NSCLC). The primary objective of the study is to demonstrate that overall survival (OS) is not worse in participants on darbepoetin alfa treated to a hemoglobin ceiling of 12.0 g/dL compared to participants treated with placebo.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Oversight Authorities continued: Colombia

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Non-Small Cell Lung Cancer Anemia Cancer Lung Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Placebo

Participants received placebo once every 3 weeks (Q3W) administered subcutaneously until 3 weeks after the completion of chemotherapy or upon determination of disease progression, whichever occurred first.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Administered subcutaneously once every 3 weeks

Darbepoetin alfa

Participants received darbepoetin alfa 500 µg once every 3 weeks (Q3W) administered subcutaneously until 3 weeks after the completion of chemotherapy or upon determination of disease progression, whichever occurred first.

Group Type EXPERIMENTAL

Darbepoetin alfa

Intervention Type DRUG

Administered subcutaneously once every 3 weeks

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Darbepoetin alfa

Administered subcutaneously once every 3 weeks

Intervention Type DRUG

Placebo

Administered subcutaneously once every 3 weeks

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Aranesp®

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Subjects with stage IV NSCLC (not recurrent or re-staged).
* Expected to receive at least 2 additional cycles (at least 6 total weeks) of first line myelosuppressive cyclic chemotherapy after randomization. Subjects should not be expected to receive only maintenance chemotherapy.
* Eastern Cooperative Oncology Group performance status of 0 or 1 as assessed within 21 days prior to randomization.
* 18 years of age or older at screening.
* Life expectancy greater than 6 months based on the judgment of the investigator and documented during screening.
* Hemoglobin level less than or equal to 11.0 g/dL as assessed by the local laboratory; sample obtained within 7 days prior to randomization (retest in screening is acceptable).
* Adequate serum folate (greater than or equal to 2 ng/mL) and vitamin B12 (greater than or equal to 200 pg/mL) levels assessed by central laboratory (supplementation and retest acceptable) during screening.
* Subjects must have had a baseline scan (computed tomography \[CT\], magnetic resonance imaging \[MRI\], or positron emission tomography-computer tomography \[PET/CT\]) of the chest to assess disease burden before starting on first line chemotherapy for NSCLC and those images must have been reviewed by the investigator prior to randomization. If the scan was performed more than 28 days prior to randomization, an additional scan must be performed and reviewed by the investigator to confirm that the patient has not progressed before randomization.
* Before any study-specific procedure, the appropriate written informed consent must be obtained from the subject or a legally accepted representative.

Exclusion Criteria

* Known primary benign or malignant hematologic disorder which can cause anemia.
* History of, or current active cancer other than NSCLC, with the exception of curatively resected non-melanomatous skin cancer, curatively treated cervical carcinoma in situ, or other primary solid tumors curatively treated with no known active disease present and no curative treatment administered for the last 3 years.
* Received any prior adjuvant or neoadjuvant therapy for NSCLC.
* Subjects with a history of brain metastasis.
* Uncontrolled hypertension (systolic blood pressure \[BP\] \> 160 mmHg or diastolic BP \> 100 mmHg), or as determined by the investigator during screening.
* History of neutralizing antibody activity to recombinant human erythropoietin (rHuEPO) or darbepoetin alfa.
* Uncontrolled angina, uncontrolled heart failure, or uncontrolled cardiac arrhythmia as determined by the investigator at screening. Subjects with known myocardial infarction within 6 months prior to randomization.
* Subjects with a history of seizure disorder taking anti-seizure medication within 30 days prior to randomization.
* Clinically significant systemic infection or uncontrolled chronic inflammatory disease (eg, rheumatoid arthritis, inflammatory bowel disease) as determined by the investigator during screening.
* Known seropositivity for human immunodeficiency virus (HIV) or diagnosis of acquired immunodeficiency syndrome (AIDS), positive for hepatitis B surface antigen, or seropositive for hepatitis C virus
* History of pure red cell aplasia
* History of deep venous thrombosis or embolic event (eg, pulmonary embolism) within 6 months prior to randomization.
* Transferrin saturation \< 20% and ferritin \< 50 ng/mL as assessed by the central laboratory during screening. Subjects must have both to be excluded (supplementation and retest acceptable).
* Abnormal renal function (serum creatinine level \> 2X upper limit of normal \[ULN\]) as assessed by the central laboratory during screening.
* Abnormal liver function (total bilirubin \> 2X ULN or liver enzymes alanine aminotransferase \[ALT\] or aspartate aminotransferase \[AST\] \> 2.5X ULN for subjects without liver metastasis or ≥ 5X ULN for subjects with liver metastasis) as assessed by the central laboratory during screening. Subjects with documented Gilbert's Disease may be eligible.
* Received any red blood cell (RBC) transfusion within 28 days prior to randomization.
* Plan to receive any RBC transfusion between randomization and study day 1.
* Known previous treatment failure to erythropoiesis stimulating agents (ESAs) (eg, rHuEPO, darbepoetin alfa).
* ESA therapy within the 28 days prior to randomization.
* Known hypersensitivity to recombinant ESAs or the excipients contained within the investigational product.
* Less than 30 days since receipt of any investigational product or device. Investigational use/receipt of a medicinal product or device that has been approved by the country's local regulatory authority for any indication is permitted.
* Subjects of reproductive potential who are pregnant, breast feeding or not willing to use effective contraceptive precautions during the study and for at least one month after the last dose of investigational product in the judgment of the investigator (including females of childbearing potential who are partners of male subjects).
* Previously randomized to this study.
* Investigator has concerns regarding the ability of the subject to give written informed consent and/or to comply with study procedures (including availability for follow up visits).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Amgen

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

MD

Role: STUDY_DIRECTOR

Amgen

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Research Site

Anniston, Alabama, United States

Site Status

Research Site

Birmingham, Alabama, United States

Site Status

Research Site

Anchorage, Alaska, United States

Site Status

Research Site

Tucson, Arizona, United States

Site Status

Research Site

Fayetteville, Arkansas, United States

Site Status

Research Site

Hot Springs, Arkansas, United States

Site Status

Research Site

Jonesboro, Arkansas, United States

Site Status

Research Site

Little Rock, Arkansas, United States

Site Status

Research Site

Anaheim, California, United States

Site Status

Research Site

Arcadia, California, United States

Site Status

Research Site

Berkeley, California, United States

Site Status

Research Site

Burbank, California, United States

Site Status

Research Site

Downey, California, United States

Site Status

Research Site

Fountain Valley, California, United States

Site Status

Research Site

Fresno, California, United States

Site Status

Research Site

Fresno, California, United States

Site Status

Research Site

La Verne, California, United States

Site Status

Research Site

Lancaster, California, United States

Site Status

Research Site

Long Beach, California, United States

Site Status

Research Site

Los Angeles, California, United States

Site Status

Research Site

Los Angeles, California, United States

Site Status

Research Site

Los Angeles, California, United States

Site Status

Research Site

Merced, California, United States

Site Status

Research Site

Mission Hills, California, United States

Site Status

Research Site

Montebello, California, United States

Site Status

Research Site

Oxnard, California, United States

Site Status

Research Site

Palm Springs, California, United States

Site Status

Research Site

Pismo Beach, California, United States

Site Status

Research Site

Pomona, California, United States

Site Status

Research Site

Redlands, California, United States

Site Status

Research Site

Salinas, California, United States

Site Status

Research Site

San Diego, California, United States

Site Status

Research Site

Santa Rosa, California, United States

Site Status

Research Site

Simi Valley, California, United States

Site Status

Research Site

Soquel, California, United States

Site Status

Research Site

St. Helena, California, United States

Site Status

Research Site

Torrance, California, United States

Site Status

Research Site

Vallejo, California, United States

Site Status

Research Site

West Covina, California, United States

Site Status

Research Site

Denver, Colorado, United States

Site Status

Research Site

Denver, Colorado, United States

Site Status

Research Site

Englewood, Colorado, United States

Site Status

Research Site

Bridgeport, Connecticut, United States

Site Status

Research Site

Southington, Connecticut, United States

Site Status

Research Site

Washington D.C., District of Columbia, United States

Site Status

Research Site

Washington D.C., District of Columbia, United States

Site Status

Research Site

Boynton Beach, Florida, United States

Site Status

Research Site

Boynton Beach, Florida, United States

Site Status

Research Site

Coral Springs, Florida, United States

Site Status

Research Site

Daytona Beach, Florida, United States

Site Status

Research Site

Fort Lauderdale, Florida, United States

Site Status

Research Site

Holiday, Florida, United States

Site Status

Research Site

Hollywood, Florida, United States

Site Status

Research Site

Jacksonville, Florida, United States

Site Status

Research Site

Kissimmee, Florida, United States

Site Status

Research Site

Lake Worth, Florida, United States

Site Status

Research Site

Lakeland, Florida, United States

Site Status

Research Site

Lecanto, Florida, United States

Site Status

Research Site

Miami, Florida, United States

Site Status

Research Site

New Port Richey, Florida, United States

Site Status

Research Site

New Port Richey, Florida, United States

Site Status

Research Site

Orange City, Florida, United States

Site Status

Research Site

Orlando, Florida, United States

Site Status

Research Site

Pembroke Pines, Florida, United States

Site Status

Research Site

Rockledge, Florida, United States

Site Status

Research Site

Tamarac, Florida, United States

Site Status

Research Site

The Villages, Florida, United States

Site Status

Research Site

Titusville, Florida, United States

Site Status

Research Site

Weston, Florida, United States

Site Status

Research Site

Albany, Georgia, United States

Site Status

Research Site

Augusta, Georgia, United States

Site Status

Research Site

Stockbridge, Georgia, United States

Site Status

Research Site

Thomasville, Georgia, United States

Site Status

Research Site

Chicago, Illinois, United States

Site Status

Research Site

Chicago, Illinois, United States

Site Status

Research Site

Galesburg, Illinois, United States

Site Status

Research Site

Gurnee, Illinois, United States

Site Status

Research Site

Mount Vernon, Illinois, United States

Site Status

Research Site

Skokie, Illinois, United States

Site Status

Research Site

Indianapolis, Indiana, United States

Site Status

Research Site

Michigan City, Indiana, United States

Site Status

Research Site

Muncie, Indiana, United States

Site Status

Research Site

Council Bluffs, Iowa, United States

Site Status

Research Site

Dubuque, Iowa, United States

Site Status

Research Site

Iowa City, Iowa, United States

Site Status

Research Site

Sioux City, Iowa, United States

Site Status

Research Site

Waterloo, Iowa, United States

Site Status

Research Site

Hutchinson, Kansas, United States

Site Status

Research Site

Wichita, Kansas, United States

Site Status

Research Site

Ashland, Kentucky, United States

Site Status

Research Site

Hazard, Kentucky, United States

Site Status

Research Site

Louisville, Kentucky, United States

Site Status

Research Site

Louisville, Kentucky, United States

Site Status

Research Site

Morehead, Kentucky, United States

Site Status

Research Site

Mount Sterling, Kentucky, United States

Site Status

Research Site

Paducah, Kentucky, United States

Site Status

Research Site

Paducah, Kentucky, United States

Site Status

Research Site

Alexandria, Louisiana, United States

Site Status

Research Site

Lafayette, Louisiana, United States

Site Status

Research Site

Marrero, Louisiana, United States

Site Status

Research Site

New Orleans, Louisiana, United States

Site Status

Research Site

Ruston, Louisiana, United States

Site Status

Research Site

Shreveport, Louisiana, United States

Site Status

Research Site

Lewiston, Maine, United States

Site Status

Research Site

Rockport, Maine, United States

Site Status

Research Site

Baltimore, Maryland, United States

Site Status

Research Site

Baltimore, Maryland, United States

Site Status

Research Site

Baltimore, Maryland, United States

Site Status

Research Site

Bethesda, Maryland, United States

Site Status

Research Site

Chevy Chase, Maryland, United States

Site Status

Research Site

Cumberland, Maryland, United States

Site Status

Research Site

Frederick, Maryland, United States

Site Status

Research Site

Hagerstown, Maryland, United States

Site Status

Research Site

Towson, Maryland, United States

Site Status

Research Site

Westminster, Maryland, United States

Site Status

Research Site

Attleboro, Massachusetts, United States

Site Status

Research Site

Boston, Massachusetts, United States

Site Status

Research Site

Boston, Massachusetts, United States

Site Status

Research Site

Brockton, Massachusetts, United States

Site Status

Research Site

Cambridge, Massachusetts, United States

Site Status

Research Site

Worcester, Massachusetts, United States

Site Status

Research Site

Clarkston, Michigan, United States

Site Status

Research Site

Grand Rapids, Michigan, United States

Site Status

Research Site

Kalamazoo, Michigan, United States

Site Status

Research Site

Southfield, Michigan, United States

Site Status

Research Site

Southgate, Michigan, United States

Site Status

Research Site

Willmar, Minnesota, United States

Site Status

Research Site

Biloxi, Mississippi, United States

Site Status

Research Site

Hattiesburg, Mississippi, United States

Site Status

Research Site

Jackson, Mississippi, United States

Site Status

Research Site

Tupelo, Mississippi, United States

Site Status

Research Site

Columbia, Missouri, United States

Site Status

Research Site

Jefferson City, Missouri, United States

Site Status

Research Site

Kansas City, Missouri, United States

Site Status

Research Site

Kansas City, Missouri, United States

Site Status

Research Site

Springfield, Missouri, United States

Site Status

Research Site

St Louis, Missouri, United States

Site Status

Research Site

St Louis, Missouri, United States

Site Status

Research Site

Great Falls, Montana, United States

Site Status

Research Site

Kalispell, Montana, United States

Site Status

Research Site

Grand Island, Nebraska, United States

Site Status

Research Site

Omaha, Nebraska, United States

Site Status

Research Site

Omaha, Nebraska, United States

Site Status

Research Site

Henderson, Nevada, United States

Site Status

Research Site

North Las Vegas, Nevada, United States

Site Status

Research Site

Manchester, New Hampshire, United States

Site Status

Research Site

Sparta, New Jersey, United States

Site Status

Research Site

Teaneck, New Jersey, United States

Site Status

Research Site

Vineland, New Jersey, United States

Site Status

Research Site

Albuquerque, New Mexico, United States

Site Status

Research Site

Santa Fe, New Mexico, United States

Site Status

Research Site

Albany, New York, United States

Site Status

Research Site

Brooklyn, New York, United States

Site Status

Research Site

Buffalo, New York, United States

Site Status

Research Site

Glens Falls, New York, United States

Site Status

Research Site

Goshen, New York, United States

Site Status

Research Site

Lake Success, New York, United States

Site Status

Research Site

Latham, New York, United States

Site Status

Research Site

Nyack, New York, United States

Site Status

Research Site

Poughkeepsie, New York, United States

Site Status

Research Site

Staten Island, New York, United States

Site Status

Research Site

Staten Island, New York, United States

Site Status

Research Site

Syracuse, New York, United States

Site Status

Research Site

Valhalla, New York, United States

Site Status

Research Site

Asheboro, North Carolina, United States

Site Status

Research Site

Asheville, North Carolina, United States

Site Status

Research Site

Burlington, North Carolina, United States

Site Status

Research Site

Concord, North Carolina, United States

Site Status

Research Site

Durham, North Carolina, United States

Site Status

Research Site

Goldsboro, North Carolina, United States

Site Status

Research Site

Greenville, North Carolina, United States

Site Status

Research Site

Hendersonville, North Carolina, United States

Site Status

Research Site

Hickory, North Carolina, United States

Site Status

Research Site

High Point, North Carolina, United States

Site Status

Research Site

Huntersville, North Carolina, United States

Site Status

Research Site

Kinston, North Carolina, United States

Site Status

Research Site

Pinehurst, North Carolina, United States

Site Status

Research Site

Raleigh, North Carolina, United States

Site Status

Research Site

Washington, North Carolina, United States

Site Status

Research Site

Bismarck, North Dakota, United States

Site Status

Research Site

Akron, Ohio, United States

Site Status

Research Site

Columbus, Ohio, United States

Site Status

Research Site

Dayton, Ohio, United States

Site Status

Research Site

Massillon, Ohio, United States

Site Status

Research Site

Middletown, Ohio, United States

Site Status

Research Site

Port Clinton, Ohio, United States

Site Status

Research Site

Sylvania, Ohio, United States

Site Status

Research Site

Wooster, Ohio, United States

Site Status

Research Site

Oklahoma City, Oklahoma, United States

Site Status

Research Site

Tulsa, Oklahoma, United States

Site Status

Research Site

Bethlehem, Pennsylvania, United States

Site Status

Research Site

Gettysburg, Pennsylvania, United States

Site Status

Research Site

Langhorne, Pennsylvania, United States

Site Status

Research Site

Philadelphia, Pennsylvania, United States

Site Status

Research Site

Philadelphia, Pennsylvania, United States

Site Status

Research Site

Philadelphia, Pennsylvania, United States

Site Status

Research Site

Philadelphia, Pennsylvania, United States

Site Status

Research Site

Philadelphia, Pennsylvania, United States

Site Status

Research Site

Pittsburgh, Pennsylvania, United States

Site Status

Research Site

Upland, Pennsylvania, United States

Site Status

Research Site

Willow Grove, Pennsylvania, United States

Site Status

Research Site

Wynnewood, Pennsylvania, United States

Site Status

Research Site

Pawtucket, Rhode Island, United States

Site Status

Research Site

Providence, Rhode Island, United States

Site Status

Research Site

Woonsocket, Rhode Island, United States

Site Status

Research Site

Aiken, South Carolina, United States

Site Status

Research Site

Charleston, South Carolina, United States

Site Status

Research Site

Charleston, South Carolina, United States

Site Status

Research Site

Columbia, South Carolina, United States

Site Status

Research Site

Hilton Head Island, South Carolina, United States

Site Status

Research Site

Myrtle Beach, South Carolina, United States

Site Status

Research Site

Sumter, South Carolina, United States

Site Status

Research Site

Aberdeen, South Dakota, United States

Site Status

Research Site

Sioux Falls, South Dakota, United States

Site Status

Research Site

Watertown, South Dakota, United States

Site Status

Research Site

Johnson City, Tennessee, United States

Site Status

Research Site

Knoxville, Tennessee, United States

Site Status

Research Site

Memphis, Tennessee, United States

Site Status

Research Site

Memphis, Tennessee, United States

Site Status

Research Site

Nashville, Tennessee, United States

Site Status

Research Site

Abilene, Texas, United States

Site Status

Research Site

Amarillo, Texas, United States

Site Status

Research Site

Austin, Texas, United States

Site Status

Research Site

Beaumont, Texas, United States

Site Status

Research Site

Bedford, Texas, United States

Site Status

Research Site

Bryan, Texas, United States

Site Status

Research Site

Corpus Christi, Texas, United States

Site Status

Research Site

Corpus Christi, Texas, United States

Site Status

Research Site

Dallas, Texas, United States

Site Status

Research Site

Dallas, Texas, United States

Site Status

Research Site

Dallas, Texas, United States

Site Status

Research Site

El Paso, Texas, United States

Site Status

Research Site

El Paso, Texas, United States

Site Status

Research Site

Fort Worth, Texas, United States

Site Status

Research Site

Garland, Texas, United States

Site Status

Research Site

Harlingen, Texas, United States

Site Status

Research Site

Houston, Texas, United States

Site Status

Research Site

Irving, Texas, United States

Site Status

Research Site

Longview, Texas, United States

Site Status

Research Site

McAllen, Texas, United States

Site Status

Research Site

Mesquite, Texas, United States

Site Status

Research Site

Midland, Texas, United States

Site Status

Research Site

Paris, Texas, United States

Site Status

Research Site

Richardson, Texas, United States

Site Status

Research Site

Round Rock, Texas, United States

Site Status

Research Site

San Antonio, Texas, United States

Site Status

Research Site

San Antonio, Texas, United States

Site Status

Research Site

Sherman, Texas, United States

Site Status

Research Site

Southlake, Texas, United States

Site Status

Research Site

Sugar Land, Texas, United States

Site Status

Research Site

Temple, Texas, United States

Site Status

Research Site

The Woodlands, Texas, United States

Site Status

Research Site

Tyler, Texas, United States

Site Status

Research Site

Tyler, Texas, United States

Site Status

Research Site

Waco, Texas, United States

Site Status

Research Site

Webster, Texas, United States

Site Status

Research Site

Wichita Falls, Texas, United States

Site Status

Research Site

Ogden, Utah, United States

Site Status

Research Site

White River Junction, Vermont, United States

Site Status

Research Site

Christiansburg, Virginia, United States

Site Status

Research Site

Fairfax, Virginia, United States

Site Status

Research Site

Lynchburg, Virginia, United States

Site Status

Research Site

Newport News, Virginia, United States

Site Status

Research Site

Portsmouth, Virginia, United States

Site Status

Research Site

Bremerton, Washington, United States

Site Status

Research Site

Burien, Washington, United States

Site Status

Research Site

Edmonds, Washington, United States

Site Status

Research Site

Seattle, Washington, United States

Site Status

Research Site

Spokane, Washington, United States

Site Status

Research Site

Spokane, Washington, United States

Site Status

Research Site

Spokane, Washington, United States

Site Status

Research Site

Tacoma, Washington, United States

Site Status

Research Site

Vancouver, Washington, United States

Site Status

Research Site

Yakima, Washington, United States

Site Status

Research Site

Green Bay, Wisconsin, United States

Site Status

Research Site

Janesville, Wisconsin, United States

Site Status

Research Site

Milwaukee, Wisconsin, United States

Site Status

Research Site

Quilmes, Buenos Aires, Argentina

Site Status

Research Site

Quilmes, Buenos Aires, Argentina

Site Status

Research Site

Córdoba, Córdoba Province, Argentina

Site Status

Research Site

Buenos Aires, Distrito Federal, Argentina

Site Status

Research Site

Buenos Aires, Distrito Federal, Argentina

Site Status

Research Site

San Salvador de Jujuy, Jujuy Province, Argentina

Site Status

Research Site

Rosario, Santa Fe Province, Argentina

Site Status

Research Site

Rosario, Santa Fe Province, Argentina

Site Status

Research Site

San Miguel de Tucumán, Tucumán Province, Argentina

Site Status

Research Site

Buenos Aires, , Argentina

Site Status

Research Site

La Rioja, , Argentina

Site Status

Research Site

Santa Fe, , Argentina

Site Status

Research Site

Steyr, , Austria

Site Status

Research Site

Vienna, , Austria

Site Status

Research Site

Ieper, , Belgium

Site Status

Research Site

Libramont, , Belgium

Site Status

Research Site

Liège, , Belgium

Site Status

Research Site

Namur, , Belgium

Site Status

Research Site

Ottignies, , Belgium

Site Status

Research Site

Fortaleza, Ceará, Brazil

Site Status

Research Site

Fortaleza, Ceará, Brazil

Site Status

Research Site

Cachoeiro de Itapemirim, Espírito Santo, Brazil

Site Status

Research Site

Salvador, Estado de Bahia, Brazil

Site Status

Research Site

Brasília, Federal District, Brazil

Site Status

Research Site

Campo Grande, Mato Grosso do Sul, Brazil

Site Status

Research Site

Belo Horizonte, Minas Gerais, Brazil

Site Status

Research Site

Belo Horizonte, Minas Gerais, Brazil

Site Status

Research Site

Belo Horizonte, Minas Gerais, Brazil

Site Status

Research Site

Belo Horizonte, Minas Gerais, Brazil

Site Status

Research Site

Curitba, Paraná, Brazil

Site Status

Research Site

Curitiba, Paraná, Brazil

Site Status

Research Site

Curitiba, Paraná, Brazil

Site Status

Research Site

Londrina, Paraná, Brazil

Site Status

Research Site

Belém, Pará, Brazil

Site Status

Research Site

Ijuí, Rio Grande do Sul, Brazil

Site Status

Research Site

Passo Fundo, Rio Grande do Sul, Brazil

Site Status

Research Site

Pelotas, Rio Grande do Sul, Brazil

Site Status

Research Site

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Research Site

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Research Site

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Research Site

Itajaí, Santa Catarina, Brazil

Site Status

Research Site

Ribeirão Preto, São Paulo, Brazil

Site Status

Research Site

Santo André, São Paulo, Brazil

Site Status

Research Site

Santo André, São Paulo, Brazil

Site Status

Research Site

São José dos Campos, São Paulo, Brazil

Site Status

Research Site

São Paulo, São Paulo, Brazil

Site Status

Research Site

São Paulo, São Paulo, Brazil

Site Status

Research Site

Rio de Janeiro, , Brazil

Site Status

Research Site

Rio de Janeiro, , Brazil

Site Status

Research Site

Rio de Janeiro, , Brazil

Site Status

Research Site

São Paulo, , Brazil

Site Status

Research Site

Rousse, , Bulgaria

Site Status

Research Site

Sofia, , Bulgaria

Site Status

Research Site

Sofia, , Bulgaria

Site Status

Research Site

Varna, , Bulgaria

Site Status

Research Site

Moncton, New Brunswick, Canada

Site Status

Research Site

Oshawa, Ontario, Canada

Site Status

Research Site

Toronto, Ontario, Canada

Site Status

Research Site

Montreal, Quebec, Canada

Site Status

Research Site

Saint-Jérôme, Quebec, Canada

Site Status

Research Site

Temuco, Cautín, Chile

Site Status

Research Site

Reñaca, Región de Valparaíso, Chile

Site Status

Research Site

Santiago, , Chile

Site Status

Research Site

Santiago, , Chile

Site Status

Research Site

Santiago, , Chile

Site Status

Research Site

Beijing, Beijing Municipality, China

Site Status

Research Site

Chongqing, Chongqing Municipality, China

Site Status

Research Site

Fuzhou, Fujian, China

Site Status

Research Site

Fuzhou, Fujian, China

Site Status

Research Site

Lanzhou, Gansu, China

Site Status

Research Site

Guangzhou, Guangdong, China

Site Status

Research Site

Guangzhou, Guangdong, China

Site Status

Research Site

Guangzhou, Guangdong, China

Site Status

Research Site

Zhongshan, Guangdong, China

Site Status

Research Site

Haikou, Hainan, China

Site Status

Research Site

Haikou, Hainan, China

Site Status

Research Site

Shijiazhuang, Hebei, China

Site Status

Research Site

Harbin, Heilongjiang, China

Site Status

Research Site

Wuhan, Hubei, China

Site Status

Research Site

Wuhan, Hubei, China

Site Status

Research Site

Changsha, Hunan, China

Site Status

Research Site

Nanjing, Jiangsu, China

Site Status

Research Site

Nanjing, Jiangsu, China

Site Status

Research Site

Suzhou, Jiangsu, China

Site Status

Research Site

Nanchang, Jiangxi, China

Site Status

Research Site

Changchun, Jilin, China

Site Status

Research Site

Changchun, Jilin, China

Site Status

Research Site

Dalian, Liaoning, China

Site Status

Research Site

Shenyang, Liaoning, China

Site Status

Research Site

Shenyang, Liaoning, China

Site Status

Research Site

Xi'an, Shaanxi, China

Site Status

Research Site

Jinan, Shandong, China

Site Status

Research Site

Chengdu, Sichuan, China

Site Status

Research Site

Chengdu, Sichuan, China

Site Status

Research Site

Ürümqi, Xinjiang, China

Site Status

Research Site

Kunming, Yunnan, China

Site Status

Research Site

Kunming, Yunnan, China

Site Status

Research Site

Hangzhou, Zhejiang, China

Site Status

Research Site

Hangzhou, Zhejiang, China

Site Status

Research Site

Hangzhou, Zhejiang, China

Site Status

Research Site

Beijing, , China

Site Status

Research Site

Beijing, , China

Site Status

Research Site

Beijing, , China

Site Status

Research Site

Beijing, , China

Site Status

Research Site

Beijing, , China

Site Status

Research Site

Chongqing, , China

Site Status

Research Site

Chongqing, , China

Site Status

Research Site

Shanghai, , China

Site Status

Research Site

Shanghai, , China

Site Status

Research Site

Shanghai, , China

Site Status

Research Site

Shanghai, , China

Site Status

Research Site

Shanghai, , China

Site Status

Research Site

Rijeka, , Croatia

Site Status

Research Site

Zagreb, , Croatia

Site Status

Research Site

Benesov U Prahy, , Czechia

Site Status

Research Site

Hořovice, , Czechia

Site Status

Research Site

Kutná Hora, , Czechia

Site Status

Research Site

Kyjov, , Czechia

Site Status

Research Site

Nová Ves pod Pleší, , Czechia

Site Status

Research Site

Ostrava-Poruba, , Czechia

Site Status

Research Site

Prague, , Czechia

Site Status

Research Site

Prague, , Czechia

Site Status

Research Site

Příbram, , Czechia

Site Status

Research Site

Bad Berka, , Germany

Site Status

Research Site

Köln-Merheim, , Germany

Site Status

Research Site

Moers, , Germany

Site Status

Research Site

München, , Germany

Site Status

Research Site

Münster, , Germany

Site Status

Research Site

Athens, , Greece

Site Status

Research Site

Athens, , Greece

Site Status

Research Site

Athens, , Greece

Site Status

Research Site

Chania, , Greece

Site Status

Research Site

Larissa, , Greece

Site Status

Research Site

Nea Kifissia, Athens, , Greece

Site Status

Research Site

Piraeus, , Greece

Site Status

Research Site

Thessaloniki, , Greece

Site Status

Research Site

Hong Kong, , Hong Kong

Site Status

Research Site

Kowloon, , Hong Kong

Site Status

Research Site

New Territories, , Hong Kong

Site Status

Research Site

Panjim, Goa, India

Site Status

Research Site

Ahmedabad, Gujarat, India

Site Status

Research Site

Bangalore, Karnataka, India

Site Status

Research Site

Mangalore, Karnataka, India

Site Status

Research Site

Kochi, Kerala, India

Site Status

Research Site

Bhopal, Madhya Pradesh, India

Site Status

Research Site

Ahilyanagar, Maharashtra, India

Site Status

Research Site

Aurangabad, Maharashtra, India

Site Status

Research Site

Thāne, Maharashtra, India

Site Status

Research Site

New Delhi, National Capital Territory of Delhi, India

Site Status

Research Site

Jaipur, Rajasthan, India

Site Status

Research Site

Jaipur, Rajasthan, India

Site Status

Research Site

Chennai, Tamil Nadu, India

Site Status

Research Site

Madurai, Tamil Nadu, India

Site Status

Research Site

Kolkata, West Bengal, India

Site Status

Research Site

Bangalore, , India

Site Status

Research Site

Dublin, , Ireland

Site Status

Research Site

Dublin, , Ireland

Site Status

Research Site

Jerusalem, , Israel

Site Status

Research Site

Kfar Saba, , Israel

Site Status

Research Site

Poria Eylit, , Israel

Site Status

Research Site

Rehovot, , Israel

Site Status

Research Site

Tel Aviv, , Israel

Site Status

Research Site

Catania, , Italy

Site Status

Research Site

Faenza RA, , Italy

Site Status

Research Site

Grosseto, , Italy

Site Status

Research Site

Lecce, , Italy

Site Status

Research Site

Legnago VR, , Italy

Site Status

Research Site

Lugo RA, , Italy

Site Status

Research Site

Meldola FC, , Italy

Site Status

Research Site

Messina, , Italy

Site Status

Research Site

Milan, , Italy

Site Status

Research Site

Napoli, , Italy

Site Status

Research Site

Ravenna, , Italy

Site Status

Research Site

Reggio Calabria, , Italy

Site Status

Research Site

San Giovanni Rotondo FG, , Italy

Site Status

Research Site

Nagoya, Aichi-ken, Japan

Site Status

Research Site

Fukui-shi, Fukui, Japan

Site Status

Research Site

Chikushino-shi, Fukuoka, Japan

Site Status

Research Site

Kurume-shi, Fukuoka, Japan

Site Status

Research Site

Amagasaki-shi, Hyōgo, Japan

Site Status

Research Site

Kobe, Hyōgo, Japan

Site Status

Research Site

Kobe, Hyōgo, Japan

Site Status

Research Site

Nishinomiya-shi, Hyōgo, Japan

Site Status

Research Site

Kanazawa, Ishikawa-ken, Japan

Site Status

Research Site

Sagamihara-shi, Kanagawa, Japan

Site Status

Research Site

Okayama, Okayama-ken, Japan

Site Status

Research Site

Osaka, Osaka, Japan

Site Status

Research Site

Osaka, Osaka, Japan

Site Status

Research Site

Bunkyo-ku, Tokyo, Japan

Site Status

Research Site

Shinjuku-ku, Tokyo, Japan

Site Status

Research Site

Yonago-shi, Tottori, Japan

Site Status

Research Site

Kyoto, , Japan

Site Status

Research Site

Esch-sur-Alzette, , Luxembourg

Site Status

Research Site

Luxembourg, , Luxembourg

Site Status

Research Site

Kota Bharu, Kelantan, Malaysia

Site Status

Research Site

Kuala Lumpur, Kuala Lumpur, Malaysia

Site Status

Research Site

Kuala Lumpur, Kuala Lumpur, Malaysia

Site Status

Research Site

Kuantan, Pahang, Malaysia

Site Status

Research Site

George Town, Pulau Pinang, Malaysia

Site Status

Research Site

Kota Kinabalu, Sabah, Malaysia

Site Status

Research Site

Saltillo, Coahuila, Mexico

Site Status

Research Site

León, Guanajuato, Mexico

Site Status

Research Site

Guadalajara, Jalisco, Mexico

Site Status

Research Site

Zapopan, Jalisco, Mexico

Site Status

Research Site

Mexico City, Mexico City, Mexico

Site Status

Research Site

Mexico City, Mexico City, Mexico

Site Status

Research Site

Mexico City, Mexico City, Mexico

Site Status

Research Site

Mexico City, Mexico City, Mexico

Site Status

Research Site

Mexico City, Mexico City, Mexico

Site Status

Research Site

Monterrey, Nuevo León, Mexico

Site Status

Research Site

Querétaro City, Querétaro, Mexico

Site Status

Research Site

San Luis Potosí City, San Luis Potosí, Mexico

Site Status

Research Site

Mérida, Yucatán, Mexico

Site Status

Research Site

Chihuahua City, , Mexico

Site Status

Research Site

Colima, , Mexico

Site Status

Research Site

Oaxaca City, , Mexico

Site Status

Research Site

Puebla City, , Mexico

Site Status

Research Site

Breda, , Netherlands

Site Status

Research Site

Eindhoven, , Netherlands

Site Status

Research Site

Rotterdam, , Netherlands

Site Status

Research Site

Tilburg, , Netherlands

Site Status

Research Site

Davao City, Davao Region, Philippines

Site Status

Research Site

Krakow, , Poland

Site Status

Research Site

Olsztyn, , Poland

Site Status

Research Site

Olsztyn, , Poland

Site Status

Research Site

Rzeszów, , Poland

Site Status

Research Site

San Juan, , Puerto Rico

Site Status

Research Site

San Juan, , Puerto Rico

Site Status

Research Site

Sibiu, , Romania

Site Status

Research Site

Arkhangelsk, , Russia

Site Status

Research Site

Barnaul, , Russia

Site Status

Research Site

Belgorod, , Russia

Site Status

Research Site

Ivanovo, , Russia

Site Status

Research Site

Kirov, , Russia

Site Status

Research Site

Krasnodar, , Russia

Site Status

Research Site

Kursk, , Russia

Site Status

Research Site

Lipetsk, , Russia

Site Status

Research Site

Moscow, , Russia

Site Status

Research Site

Nizhny Novgorod, , Russia

Site Status

Research Site

Novosibirsk, , Russia

Site Status

Research Site

Obninsk, , Russia

Site Status

Research Site

Omsk, , Russia

Site Status

Research Site

Orenburg, , Russia

Site Status

Research Site

Penza, , Russia

Site Status

Research Site

Pyatigorsk, , Russia

Site Status

Research Site

Saint Petersburg, , Russia

Site Status

Research Site

Samara, , Russia

Site Status

Research Site

Saratov, , Russia

Site Status

Research Site

Stavropol, , Russia

Site Status

Research Site

Tula, , Russia

Site Status

Research Site

Tver', , Russia

Site Status

Research Site

Ufa, , Russia

Site Status

Research Site

Ulyanovsk, , Russia

Site Status

Research Site

Voronezh, , Russia

Site Status

Research Site

Yaroslavl, , Russia

Site Status

Research Site

Belgrade, , Serbia

Site Status

Research Site

Gornji Matejevac, , Serbia

Site Status

Research Site

Kamenitz, , Serbia

Site Status

Research Site

Kragujevac, , Serbia

Site Status

Research Site

Golnik, , Slovenia

Site Status

Research Site

Pohorje, , Slovenia

Site Status

Research Site

Umhlanga, KwaZulu-Natal, South Africa

Site Status

Research Site

Bloemfontein, , South Africa

Site Status

Research Site

Johannesburg, , South Africa

Site Status

Research Site

Overport, , South Africa

Site Status

Research Site

Polokwane, , South Africa

Site Status

Research Site

Gwangju, , South Korea

Site Status

Research Site

Seongnam-si, Gyeonggido, , South Korea

Site Status

Research Site

Seoul, , South Korea

Site Status

Research Site

Granada, Andalusia, Spain

Site Status

Research Site

Las Palmas de Gran Canaria, Canary Islands, Spain

Site Status

Research Site

Barcelona, Catalonia, Spain

Site Status

Research Site

Pontevedra, Galicia, Spain

Site Status

Research Site

Alicante, Valencia, Spain

Site Status

Research Site

Benidorm, Valencia, Spain

Site Status

Research Site

Valencia, Valencia, Spain

Site Status

Research Site

Aarau, , Switzerland

Site Status

Research Site

Aarau, , Switzerland

Site Status

Research Site

Chur, , Switzerland

Site Status

Research Site

Sursee, , Switzerland

Site Status

Research Site

Zurich, , Switzerland

Site Status

Research Site

Kaohsiung City, , Taiwan

Site Status

Research Site

Taichung, , Taiwan

Site Status

Research Site

Kirovograd, , Ukraine

Site Status

Research Site

Bebington, , United Kingdom

Site Status

Research Site

Dorechester, , United Kingdom

Site Status

Research Site

Dorset, , United Kingdom

Site Status

Research Site

Liverpool, , United Kingdom

Site Status

Research Site

Manchester, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Argentina Austria Belgium Brazil Bulgaria Canada Chile China Croatia Czechia Germany Greece Hong Kong India Ireland Israel Italy Japan Luxembourg Malaysia Mexico Netherlands Philippines Poland Puerto Rico Romania Russia Serbia Slovenia South Africa South Korea Spain Switzerland Taiwan Ukraine United Kingdom

References

Explore related publications, articles, or registry entries linked to this study.

Gascon P, Nagarkar R, Smakal M, Syrigos KN, Barrios CH, Sanchez JC, Zhang L, Henry DH, Gordon D, Hirsh V, Kubota K, Orlov S, Thomas G, Steinmetz T, Kang JH, Tomita DK, Fleishman AN, Park JK, De Oliveira Brandao C. A Randomized, Double-Blind, Placebo-Controlled, Phase III Noninferiority Study of the Long-Term Safety and Efficacy of Darbepoetin Alfa for Chemotherapy-Induced Anemia in Patients With Advanced NSCLC. J Thorac Oncol. 2020 Feb;15(2):190-202. doi: 10.1016/j.jtho.2019.10.005. Epub 2019 Oct 16.

Reference Type BACKGROUND
PMID: 31629060 (View on PubMed)

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Related Links

Access external resources that provide additional context or updates about the study.

http://www.amgentrials.com

AmgenTrials clinical trials website

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2007-005792-34

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

20070782

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Chemotherapy Related Anemia
NCT00035607 COMPLETED PHASE2
Darbepoetin Alfa and Anemia of Cancer
NCT00989092 TERMINATED PHASE2