Racial Differences in Phosphorus Metabolism

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-02-28

Study Completion Date

2011-06-30

Brief Summary

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The investigators aim to study potential racial differences in renal phosphorus handling by provocatively testing urinary phosphorus excretion using parathyroid hormone infusions in healthy white volunteers compared to healthy black volunteers.

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Detailed Description

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Conditions

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Control

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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PTH infusion

(1-34) PTH infusion at a rate of 0.055 ug/kg/hour for six hours

Group Type EXPERIMENTAL

1-34 parathyroid infusion

Intervention Type DRUG

1-34 parathyroid infusion at 0.055 mcg/kg/hr for 6 hours

Interventions

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1-34 parathyroid infusion

1-34 parathyroid infusion at 0.055 mcg/kg/hr for 6 hours

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 18 years of age or older
* Body mass index (BMI) within 20% ideal for their age and gender

Exclusion Criteria

* Abnormal urinalysis
* Pregnancy or breast-feeding
* Medical conditions impacting phosphorus metabolism-primary hyperparathyroidism; diabetes mellitus; gastrointestinal malabsorption disorders; hyper- or hypothyroidism
* Medications known to affect phosphorus metabolism- current use of phosphorus supplements, phosphorus binders, calcitriol or calcitriol analogues, regular antacid or laxative use, calcitonin, etidronate, anticonvulsants
* Hyper- or hypophosphatemia (≥ 4.6 mg/dl or ≤ 2.5 mg/dl respectively), hyper- or hypocalcemia (≥ 10.6 or ≤ 8.5 mg/dl respectively), or severe anemia (Hgb \< 8 g/dl for women and \< 9 g/dl for men)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes