Co-existent Obstructive Sleep Apnea (OSA) and Obesity: Finding Non-exercise Activity Thermogenesis (NEAT) Targets for Intervention

NCT ID: NCT00854334

Last Updated: 2018-03-09

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 9 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-09-30
• Study Completion Date: 2012-12-31

Brief Summary

Rationale: Obesity is an increasing childhood epidemic in Canada. Obstructive sleep apnea (OSA) is a complication of obesity which causes cardiovascular disease, reduced quality of life, and premature death. While the complex interactions between obesity and OSA are not entirely clear, we hypothesize that these conditions may compound each other by:

1. decreasing physical activity and total energy expenditure by reducing both non-exercise physical pursuits (NEAT- non-exercise activity thermogenesis) and purposeful physical activity.

2. alterations in the secretion of appetite-controlling hormones, which may lead to increases in energy intake.

Objective: To determine whether the presence of both obesity and OSA in children is associated with a decrease in physical activity and alterations in appetite-regulating hormones greater than those seen in either condition alone or compared to controls.

Methods: Comparison of children 10-17 years with obesity and OSA, obesity alone, OSA alone and neither condition, for the following outcomes: (1) NEAT (kcal/day) (2) Physical activity behavior, appetite regulating hormone profile and self-report appetite assessment.

Unique Aspects: This study combines expertise in sleep medicine, exercise physiology and obesity. Conclusions from this study will better characterize this high-risk clinical population so that innovative strategies targeting improvements in lifestyle behaviors can be developed.

Conditions

Childhood Obesity; Childhood Obstructive Sleep Apnea

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

1.

Children with both obesity and obstructive sleep apnea

No interventions assigned to this group

2

Children without the presence of both obesity and obstructive sleep apnea

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• age 10-17 years
• coming for polysomnography at the Children's Hospital of Eastern Ontario

Exclusion Criteria

• children receiving treatment for OSA with CPAP (continuous positive airway pressure) or bi-level therapy
• craniofacial abnormalities
• genetic syndromes
• neuromuscular disease
• tracheostomy
• medications that may affect appetite or energy balance (systemic corticosteroids)

• Minimum Eligible Age: 10 Years
• Maximum Eligible Age: 17 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Katz, Sherri Lynne, M.D.

INDIV

Sponsor Role: lead

Responsible Party

Dr. Sherry Lynn Katz

Katz, Sherri Lynne, M.D.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Childrens Hospital of Eastern Ontario

Ottawa, Ontario, Canada

Countries

Canada

Other Identifiers

Neat-OSA-001

Identifier Type: -

Identifier Source: org_study_id