MK-0431/ONO-5435 Phase III Clinical Trial - Insulin Add-on Study for Patients With Type 2 Diabetes Mellitus

NCT ID: NCT00854035

Last Updated: 2012-06-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

266 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-02-28

Brief Summary

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This Phase III clinical trial will examine the efficacy, safety, and tolerability of the addition of MK-0431/ONO-5435 to Japanese patients with Type 2 Diabetes Mellitus who have inadequate glycemic control on diet/exercise therapy and insulin monotherapy.

Detailed Description

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Conditions

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Type 2 Diabetes Mellitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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E

Group Type EXPERIMENTAL

MK-0431/ONO-5435

Intervention Type DRUG

Double-blind period (16 wk); 50 mg QD. The double-blind period will be followed by a 36 wk open-label extension period where MK-0431/ONO-5435 could be titrated from 50mg QD to 100mg QD

P

Group Type PLACEBO_COMPARATOR

MK-0431/ONO-5435

Intervention Type DRUG

Double-blind period (16 wk); placebo QD. The double-blind period will be followed by a 36 wk open-label extension period where MK-0431/ONO-5435 could be titrated from 50 mg QD to 100 mg QD

Interventions

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MK-0431/ONO-5435

Double-blind period (16 wk); 50 mg QD. The double-blind period will be followed by a 36 wk open-label extension period where MK-0431/ONO-5435 could be titrated from 50mg QD to 100mg QD

Intervention Type DRUG

MK-0431/ONO-5435

Double-blind period (16 wk); placebo QD. The double-blind period will be followed by a 36 wk open-label extension period where MK-0431/ONO-5435 could be titrated from 50 mg QD to 100 mg QD

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Japanese Patients with Type 2 Diabetes Mellitus who have inadequate glycemic control on diet/exercise therapy and insulin monotherapy

Exclusion Criteria

* Patients with Type 1 Diabetes Mellitus
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ono Pharmaceutical Co. Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Seki Akiteru

Role: STUDY_CHAIR

First Division Clinical Development Planning I

Locations

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Chugoku Region

Chugoku, , Japan

Site Status

Chubu Region

Chūbu, , Japan

Site Status

Hokuriku Region

Hokuriku, , Japan

Site Status

Kanto Region

Kanto, , Japan

Site Status

Kinki Region

Kinki, , Japan

Site Status

Kyushu Region

Kyushu, , Japan

Site Status

Tohoku Region

Tōhoku, , Japan

Site Status

Countries

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Japan

Other Identifiers

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ONO-5435-15

Identifier Type: -

Identifier Source: org_study_id

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