Study of the Safety and Efficacy of RGH-896 in Patients With Diabetic Peripheral Neuropathic Pain

NCT ID: NCT00838799

Last Updated: 2011-07-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

458 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study is designed to evaluate the safety and efficacy of RGH-896 in patients with diabetic peripheral neuropathic pain.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Diabetic Peripheral Neuropathic Pain

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Group Type EXPERIMENTAL

RGH-896

Intervention Type DRUG

45 mg TID, capsules, 14 weeks.

2

Group Type EXPERIMENTAL

RGH-896

Intervention Type DRUG

30 mg TID, capsules, 14 weeks.

3

Group Type EXPERIMENTAL

RGH-896

Intervention Type DRUG

15 mg TID, capsules, 14 weeks.

4

Group Type ACTIVE_COMPARATOR

pregabalin

Intervention Type DRUG

100 mg, TID, capsules, 14 weeks.

5

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

TID, capsules, 14 weeks.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

RGH-896

45 mg TID, capsules, 14 weeks.

Intervention Type DRUG

RGH-896

30 mg TID, capsules, 14 weeks.

Intervention Type DRUG

RGH-896

15 mg TID, capsules, 14 weeks.

Intervention Type DRUG

pregabalin

100 mg, TID, capsules, 14 weeks.

Intervention Type DRUG

placebo

TID, capsules, 14 weeks.

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Lyrica

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Male or female outpatients 18 to 75 years of age
* A diagnosis of painful diabetic neuropathy
* Controlled blood glucose
* Willingness to wash out all analgesic medications used for DPNP
* Female patients either postmenopausal, surgically sterile, or practicing a medically acceptable method of contraception
* Female patients who are not pregnant

Exclusion Criteria

* Acute infections or cardiac problems
* Past use of pregabalin
* History of severe psychiatric disorder
* History of any amputation due to diabetes
* History of seizure disorder
* Active diabetic foot ulcers
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Gedeon Richter Ltd.

INDUSTRY

Sponsor Role collaborator

Forest Laboratories

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Forest Research Institute, a subsidiary of Forest Laboratories, Inc.

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Allyson Gage, PhD

Role: STUDY_DIRECTOR

Forest Research Institute, a subsidiary of Forest Laboratories Inc.

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Forest Investigative Site

Birmingham, Alabama, United States

Site Status

Forest Investigative Site

Mesa, Arizona, United States

Site Status

Forest Investigative Site

Tempe, Arizona, United States

Site Status

Forest Investigative Site

Jonesboro, Arkansas, United States

Site Status

Forest Investigative Site

Little Rock, Arkansas, United States

Site Status

Forest Investigative Site

North Little Rock, Arkansas, United States

Site Status

Forest Investigative Site

Anaheim, California, United States

Site Status

Forest Investigative Site

Burbank, California, United States

Site Status

Forest Investigative Site

Lakewood, California, United States

Site Status

Forest Investigative Site

National City, California, United States

Site Status

Forest Investigative Site

Riverside, California, United States

Site Status

Forest Investigative Site

Sacramento, California, United States

Site Status

Forest Investigative Site

San Diego, California, United States

Site Status

Forest Investigative Site

Santa Monica, California, United States

Site Status

Forest Investigative Site

Tustin, California, United States

Site Status

Forest Investigative Site

Walnut Creek, California, United States

Site Status

Forest Investigative Site

Westlake Village, California, United States

Site Status

Forest Investigative Site

Boulder, Colorado, United States

Site Status

Forest Investigative Site

New Britain, Connecticut, United States

Site Status

Forest Investigative Site

Bradenton, Florida, United States

Site Status

Forest Investigative Site

Brandon, Florida, United States

Site Status

Forest Investigative Site

DeLand, Florida, United States

Site Status

Forest Investigative Site

Hollywood, Florida, United States

Site Status

Forest Investigative Site

Jacksonville, Florida, United States

Site Status

Forest Investigative Site

Miami, Florida, United States

Site Status

Forest Investigative Site

Orlando, Florida, United States

Site Status

Forest Investigative Site

Pembroke Pines, Florida, United States

Site Status

Forest Investigative Site

Tampa, Florida, United States

Site Status

Forest Investigative Site

West Palm Beach, Florida, United States

Site Status

Forest Investigative Site

Honolulu, Hawaii, United States

Site Status

Forest Investigative Site

Boise, Idaho, United States

Site Status

Forest Investigative Site

Wichita, Kansas, United States

Site Status

Forest Investigative Site

Covington, Louisiana, United States

Site Status

Forest Investigative Site

Owings Mills, Maryland, United States

Site Status

Forest Investigative Site

St Louis, Missouri, United States

Site Status

Forest Investigative Site

West Caldwell, New Jersey, United States

Site Status

Forest Investigative Site

Albuquerque, New Mexico, United States

Site Status

Forest Investigative Site

New York, New York, United States

Site Status

Forest Investigative Site

Charlotte, North Carolina, United States

Site Status

Forest Investigative Site

Greenville, North Carolina, United States

Site Status

Forest Investigative Site

Winston-Salem, North Carolina, United States

Site Status

Forest Investigative Site

Cleveland, Ohio, United States

Site Status

Forest Investigative Site

Kettering, Ohio, United States

Site Status

Forest Investigative Site

Tulsa, Oklahoma, United States

Site Status

Forest Investigative Site

Duncansville, Pennsylvania, United States

Site Status

Forest Investigative Site

Philadelphia, Pennsylvania, United States

Site Status

Forest Investigative Site

Columbia, South Carolina, United States

Site Status

Forest Investigative Site

Memphis, Tennessee, United States

Site Status

Forest Investigative Site

Dallas, Texas, United States

Site Status

Forest Investigative Site

Lake Jackson, Texas, United States

Site Status

Forest Investigative Site

San Antonio, Texas, United States

Site Status

Forest Investigative Site

Salt Lake City, Utah, United States

Site Status

Forest Investigative Site

Virginia Beach, Virginia, United States

Site Status

Forest Investigative Site

Tacoma, Washington, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

RG8-MD-02

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.