Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia
NCT ID: NCT00835341
Last Updated: 2015-06-01
Study Results
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View full resultsBasic Information
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COMPLETED
93 participants
OBSERVATIONAL
2005-03-31
2008-10-31
Brief Summary
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Detailed Description
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* Methods: 101 patients with histologically confirmed mild or moderate OED were included in the present study. Baseline information of p16 methylation status of the OED lesions from 93 cases was obtained by methylation-specific PCR. Progression of the OEDs lesions was examined in 78 cases histologically during the 45.8 months double-blind followup survey (78/93). The association between p16 methylation and progression of OED was analyzed with SPSS13.0 software. All P-values were two-sided.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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p16-methylated
patients with mild or moderate oral epithelial dysplasia containing methylated p16 CpG island.
No interventions assigned to this group
p16-unmethylated
patients with mild or moderate oral epithelial dysplasia NOT containing methylated p16 CpG island.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* enough amount of tissue sample from OED lesion for genomic DNA extraction; and
* available of methylation status of p16 CpG island in the extracted DNA sample.
Exclusion Criteria
* amount of tissue sample is not enough for preparation of genomic DNA (20ng); or
* quality of the prepared DNA is not good enough for detection of p16 methylation; or
* OED treatment history by LASER, radiotherapy, or chemotherapy
ALL
No
Sponsors
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Peking University
OTHER
Responsible Party
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Dajun Deng
Professor and Department Director
Principal Investigators
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Dajun Deng, MD
Role: STUDY_DIRECTOR
Beijing Cancer Hospital/ Institue, Peking University School of Oncology
Hongwei Liu, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Peking University School of Stomatology
Locations
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Department of Oral Medicine, Peking University School and Hospital of Stomatology
Beijing, , China
Countries
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References
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Gale N, Westra W, Pilch BZ, et al. Epithelial precursors lesions. In: Barnes L, Eveson JW, Reichart P, et al. eds. World Health Organization Classification of Tumors: Pathology and Genetics of Head and Neck Tumors. IARC Press, Lyon (France); 2005: 177-179.
Sun Y, Deng D, You WC, Bai H, Zhang L, Zhou J, Shen L, Ma JL, Xie YQ, Li JY. Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study. Clin Cancer Res. 2004 Aug 1;10(15):5087-93. doi: 10.1158/1078-0432.CCR-03-0622.
Cao J, Zhou J, Gao Y, Gu L, Meng H, Liu H, Deng D. Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study. Clin Cancer Res. 2009 Aug 15;15(16):5178-83. doi: 10.1158/1078-0432.CCR-09-0580. Epub 2009 Aug 11.
Related Links
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Beijing Cancer Hospital/ Institute, Peking University School of Oncology
Peking University School of Stomatology
Other Identifiers
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CPDHS-434
Identifier Type: -
Identifier Source: org_study_id
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