Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration

NCT ID: NCT00832663

Last Updated: 2010-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-04-30

Study Completion Date

2009-12-31

Brief Summary

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The purpose of this study is to determine the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on muscle regeneration.

The investigators' hypothesis is that ingestion of NSAID will delay or impair muscle regeneration.

Detailed Description

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The model employed to induce muscle damage is electrical stimulation. Muscle biopsies will be examined to follow the response of satellite cells and muscle regeneration. Study participants will be randomly assigned to a placebo or NSAID group in a double-blinded manner.

Conditions

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Muscle Damage

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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NSAID

receive NSAID

Group Type EXPERIMENTAL

NSAID

Intervention Type DRUG

Effect of NSAID ingestion on muscle regeneration

Placebo

receive placebo

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

receive placebo

Interventions

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NSAID

Effect of NSAID ingestion on muscle regeneration

Intervention Type DRUG

placebo

receive placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* male
* healthy
* does not exercise regularly

Exclusion Criteria

* displays contraindications for taking NSAID
* well-trained
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Lundbeck Foundation

OTHER

Sponsor Role collaborator

Team Denmark

OTHER

Sponsor Role collaborator

Danish Ministry of Culture

UNKNOWN

Sponsor Role collaborator

Anti Doping Danmark

OTHER

Sponsor Role collaborator

The Danish Rheumatism Association

OTHER

Sponsor Role collaborator

King Christian IX and Queen Louise Jubilee Bursary

UNKNOWN

Sponsor Role collaborator

Bispebjerg Hospital

OTHER

Sponsor Role lead

Responsible Party

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Institute of Sports Medicine Copenhagen

Principal Investigators

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Abigail L Mackey, PhD

Role: PRINCIPAL_INVESTIGATOR

Institute of Sports Medicine Copenhagen, Bispebjerg Hospital

Locations

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Bispebjerg Hospital

Copenhagen, NV, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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H-D-2008-074

Identifier Type: -

Identifier Source: secondary_id

AM_P64_BBH

Identifier Type: -

Identifier Source: org_study_id

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