Measles Vaccine in Patients With Measles Virus-Positive, Advanced Non-Small Cell Lung Cancer

NCT ID: NCT00828022

Last Updated: 2009-01-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1/PHASE2

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-03-31

Brief Summary

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The objectives of the study are to assess the efficacy and safety of live, attenuated measles vaccine as consolidation therapy in patients with measles-positive, non-small cell lung cancer with locally-advanced (stage 3B with pleural effusion) or metastatic (stage 4) tumors in remission.

Detailed Description

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This is a single-institution, non-randomized phase 1/2 study in patients with locally-advanced or metastatic NSCLC in remission after receiving standard systemic chemotherapy of four cycles of combination chemotherapy consisting of four cycles of cisplatin combined with vinorelbine.

Conditions

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Non-Small Cell Lung Cancer Measles

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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attenuated measles vaccine

4-week apart, two vaccines starting 4 weeks after last chemotherapy

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Patients in remission after first-line chemotherapy

Exclusion Criteria

* Progressive disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Soroka University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Department of Oncology, Soroka Medical Center, Beer Sheva

Locations

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Department of Oncology, Soroka Medical Center

Beersheba, , Israel

Site Status

Countries

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Israel

Central Contacts

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Samuel Ariad, MD

Role: CONTACT

972-8-6400537

Other Identifiers

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sor469208ctil

Identifier Type: -

Identifier Source: org_study_id

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