A Study of the Impact of an Early Biopsy in Patients Treated With CellCept (Mycophenolate Mofetil) After Kidney Transplantation

NCT ID: NCT00817687

Last Updated: 2012-07-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-01-31

Study Completion Date

2012-01-31

Brief Summary

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This 2 arm study will evaluate the impact on fibrosis at week 52 of an early biopsy, in patients who have received a kidney transplant from an expanded criteria donor. Patients will be randomized to one of two groups; the first group will have a biopsy at day 10, and the second group will receive standard management. All patients will be given CellCept as standard of care. The anticipated time on study treatment is 1 year, and the target sample size is 100-500 individuals.

Detailed Description

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Conditions

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Kidney Transplantation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

mycophenolate mofetil [CellCept]

Intervention Type DRUG

As prescribed; + early biopsy

2

Group Type NO_INTERVENTION

mycophenolate mofetil [CellCept]

Intervention Type DRUG

As prescribed; + standard treatment

Interventions

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mycophenolate mofetil [CellCept]

As prescribed; + early biopsy

Intervention Type DRUG

mycophenolate mofetil [CellCept]

As prescribed; + standard treatment

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients, \>=18 years of age;
* in receipt of an initial cadaveric kidney transplant;
* in receipt of graft with biopsy;
* in receipt of a 'marginal' kidney transplant.

Exclusion Criteria

* in receipt of a second kidney transplant;
* in receipt of a multi-organ transplant or a double kidney transplant;
* malignant tumor, or a history of cancer in past 5 years, other than successfully treated basal cell or spinocellular cancer or cancer in situ of cervix;
* replicating hepatitis B and/or C, or HIV positive serology.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Besançon, , France

Site Status

Bordeaux, , France

Site Status

Caen, , France

Site Status

Clermont-Ferrand, , France

Site Status

Lille, , France

Site Status

Limoges, , France

Site Status

Marseille, , France

Site Status

Nantes, , France

Site Status

Paris, , France

Site Status

Paris, , France

Site Status

Poitiers, , France

Site Status

Rouen, , France

Site Status

Salouël, , France

Site Status

Strasbourg, , France

Site Status

Suresnes, , France

Site Status

Tours, , France

Site Status

Vandœuvre-lès-Nancy, , France

Site Status

Countries

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France

Other Identifiers

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ML21655

Identifier Type: -

Identifier Source: org_study_id