Diagnostic Endoscopic Exploration for Pancreatic Head Mass

NCT ID: NCT00816179

Last Updated: 2014-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-07-31

Study Completion Date

2014-08-31

Brief Summary

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This study is being done to find out if an endoscope passed down the throat, through the stomach, and into the abdomen can quickly and accurately examine the organs and tissue of the abdomen and take biopsies if needed.

Detailed Description

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This study is being done to find out if an endoscope (a small, flexible tube with a camera mounted on the end) passed down the throat, through the stomach, and into the abdomen can quickly and accurately examine the organs and tissue of the abdomen and take biopsies if needed. We wish to determine if this endoscopic route is as fast and efficient as the laparoscopic route, which is the current standard of care.

Conditions

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Pancreatic Head Mass

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Interventions

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Transgastric diagnostic endoscopic peritoneoscopy

Endoscopic abdominal exploration utilizing an endoscopically created gastrotomy.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age range 18-80
* Radiographic diagnosis of resectable pancreatic head mass presumed to be pancreatic adenocarcinoma

Exclusion Criteria

* Inability to obtain informed consent
* Pregnancy
* Intra-abdominal adhesions that preclude endoscopy
* Contraindication to upper endoscopy such as stricture, stenosis of the foregut
* Previous gastric surgery
* Diagnosis of pancreatic body or tail tumor
* History or current diagnosis of gastric ulcer
* Metastatic disease diagnosed by CT, EUS, MRI, or nuclear imaging
* Patient is not a candidate for resection based upon CT, EUS, MRI, or nuclear imaging
* Antiplatelet medication not stopped at least 7 days prior to procedure
* Anticoagulant medication not stopped at least 5 days prior to procedure
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Natural Orifice Surgery Consortium for Assessment and Research

OTHER

Sponsor Role collaborator

Jeffrey Hazey

OTHER

Sponsor Role lead

Responsible Party

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Jeffrey Hazey

Associate Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Jeffrey W Hazey, MD

Role: PRINCIPAL_INVESTIGATOR

OSUMC

Locations

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The Ohio State University Medical Center

Columbus, Ohio, United States

Site Status

Countries

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United States

References

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Rattner D, Kalloo A; ASGE/SAGES Working Group. ASGE/SAGES Working Group on Natural Orifice Translumenal Endoscopic Surgery. October 2005. Surg Endosc. 2006 Feb;20(2):329-33. doi: 10.1007/s00464-005-3006-0. No abstract available.

Reference Type BACKGROUND
PMID: 16402290 (View on PubMed)

White R, Winston C, Gonen M, D'Angelica M, Jarnagin W, Fong Y, Conlon K, Brennan M, Allen P. Current utility of staging laparoscopy for pancreatic and peripancreatic neoplasms. J Am Coll Surg. 2008 Mar;206(3):445-50. doi: 10.1016/j.jamcollsurg.2007.09.021. Epub 2007 Nov 26.

Reference Type BACKGROUND
PMID: 18308214 (View on PubMed)

Lillemoe KD, Cameron JL, Hardacre JM, Sohn TA, Sauter PK, Coleman J, Pitt HA, Yeo CJ. Is prophylactic gastrojejunostomy indicated for unresectable periampullary cancer? A prospective randomized trial. Ann Surg. 1999 Sep;230(3):322-8; discussion 328-30. doi: 10.1097/00000658-199909000-00005.

Reference Type BACKGROUND
PMID: 10493479 (View on PubMed)

Ponsky JL. Gastroenterologists as surgeons: what they need to know. Gastrointest Endosc. 2005 Mar;61(3):454. doi: 10.1016/s0016-5107(04)02632-x. No abstract available.

Reference Type BACKGROUND
PMID: 15758924 (View on PubMed)

Wagh MS, Merrifield BF, Thompson CC. Endoscopic transgastric abdominal exploration and organ resection: initial experience in a porcine model. Clin Gastroenterol Hepatol. 2005 Sep;3(9):892-6. doi: 10.1016/s1542-3565(05)00296-x.

Reference Type BACKGROUND
PMID: 16234027 (View on PubMed)

Merrifield BF, Wagh MS, Thompson CC. Peroral transgastric organ resection: a feasibility study in pigs. Gastrointest Endosc. 2006 Apr;63(4):693-7. doi: 10.1016/j.gie.2005.11.043.

Reference Type BACKGROUND
PMID: 16564875 (View on PubMed)

Kalloo AN, Singh VK, Jagannath SB, Niiyama H, Hill SL, Vaughn CA, Magee CA, Kantsevoy SV. Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity. Gastrointest Endosc. 2004 Jul;60(1):114-7. doi: 10.1016/s0016-5107(04)01309-4.

Reference Type BACKGROUND
PMID: 15229442 (View on PubMed)

Ikeda K, Fritscher-Ravens A, Mosse CA, Mills T, Tajiri H, Swain CP. Endoscopic full-thickness resection with sutured closure in a porcine model. Gastrointest Endosc. 2005 Jul;62(1):122-9. doi: 10.1016/s0016-5107(05)00517-1.

Reference Type BACKGROUND
PMID: 15990831 (View on PubMed)

Onders RP, McGee MF, Marks J, Chak A, Rosen MJ, Ignagni A, Faulx A, Schomisch S, Ponsky J. Natural orifice transluminal endoscopic surgery (NOTES) as a diagnostic tool in the intensive care unit. Surg Endosc. 2007 Apr;21(4):681-3. doi: 10.1007/s00464-007-9214-z. Epub 2007 Feb 16.

Reference Type BACKGROUND
PMID: 17364154 (View on PubMed)

Lima E, Rolanda C, Pego JM, Henriques-Coelho T, Silva D, Carvalho JL, Correia-Pinto J. Transvesical endoscopic peritoneoscopy: a novel 5 mm port for intra-abdominal scarless surgery. J Urol. 2006 Aug;176(2):802-5. doi: 10.1016/j.juro.2006.03.075.

Reference Type BACKGROUND
PMID: 16813951 (View on PubMed)

McGee MF, Rosen MJ, Marks J, Chak A, Onders R, Faulx A, Ignagni A, Schomisch S, Ponsky J. A reliable method for monitoring intraabdominal pressure during natural orifice translumenal endoscopic surgery. Surg Endosc. 2007 Apr;21(4):672-6. doi: 10.1007/s00464-006-9124-5. Epub 2007 Feb 7.

Reference Type BACKGROUND
PMID: 17285385 (View on PubMed)

Kantsevoy SV, Hu B, Jagannath SB, Vaughn CA, Beitler DM, Chung SS, Cotton PB, Gostout CJ, Hawes RH, Pasricha PJ, Magee CA, Pipitone LJ, Talamini MA, Kalloo AN. Transgastric endoscopic splenectomy: is it possible? Surg Endosc. 2006 Mar;20(3):522-5. doi: 10.1007/s00464-005-0263-x. Epub 2006 Jan 21.

Reference Type BACKGROUND
PMID: 16432652 (View on PubMed)

Kantsevoy SV, Jagannath SB, Niiyama H, Chung SS, Cotton PB, Gostout CJ, Hawes RH, Pasricha PJ, Magee CA, Vaughn CA, Barlow D, Shimonaka H, Kalloo AN. Endoscopic gastrojejunostomy with survival in a porcine model. Gastrointest Endosc. 2005 Aug;62(2):287-92. doi: 10.1016/s0016-5107(05)01565-8.

Reference Type BACKGROUND
PMID: 16046997 (View on PubMed)

Bergstrom M, Ikeda K, Swain P, Park PO. Transgastric anastomosis by using flexible endoscopy in a porcine model (with video). Gastrointest Endosc. 2006 Feb;63(2):307-12. doi: 10.1016/j.gie.2005.09.035.

Reference Type BACKGROUND
PMID: 16427940 (View on PubMed)

Park PO, Bergstrom M, Ikeda K, Fritscher-Ravens A, Swain P. Experimental studies of transgastric gallbladder surgery: cholecystectomy and cholecystogastric anastomosis (videos). Gastrointest Endosc. 2005 Apr;61(4):601-6. doi: 10.1016/s0016-5107(04)02774-9.

Reference Type BACKGROUND
PMID: 15812420 (View on PubMed)

Pai RD, Fong DG, Bundga ME, Odze RD, Rattner DW, Thompson CC. Transcolonic endoscopic cholecystectomy: a NOTES survival study in a porcine model (with video). Gastrointest Endosc. 2006 Sep;64(3):428-34. doi: 10.1016/j.gie.2006.06.079.

Reference Type BACKGROUND
PMID: 16923495 (View on PubMed)

Jagannath SB, Kantsevoy SV, Vaughn CA, Chung SS, Cotton PB, Gostout CJ, Hawes RH, Pasricha PJ, Scorpio DG, Magee CA, Pipitone LJ, Kalloo AN. Peroral transgastric endoscopic ligation of fallopian tubes with long-term survival in a porcine model. Gastrointest Endosc. 2005 Mar;61(3):449-53. doi: 10.1016/s0016-5107(04)02828-7.

Reference Type BACKGROUND
PMID: 15758923 (View on PubMed)

Wagh MS, Merrifield BF, Thompson CC. Survival studies after endoscopic transgastric oophorectomy and tubectomy in a porcine model. Gastrointest Endosc. 2006 Mar;63(3):473-8. doi: 10.1016/j.gie.2005.06.045.

Reference Type BACKGROUND
PMID: 16500399 (View on PubMed)

Sclabas GM, Swain P, Swanstrom LL. Endoluminal methods for gastrotomy closure in natural orifice transenteric surgery (NOTES). Surg Innov. 2006 Mar;13(1):23-30. doi: 10.1177/155335060601300105.

Reference Type BACKGROUND
PMID: 16708152 (View on PubMed)

Ko CW, Kalloo AN. Per-oral transgastric abdominal surgery. Chin J Dig Dis. 2006;7(2):67-70. doi: 10.1111/j.1443-9573.2006.00256.x.

Reference Type BACKGROUND
PMID: 16643332 (View on PubMed)

Related Links

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http://cmis.osu.edu/

Home page for OSUMC Center for Minimally Invasive Surgery

Other Identifiers

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2007C0086

Identifier Type: -

Identifier Source: org_study_id

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