The Effects of Potassium on Physiological and Cardiovascular Variables in Healthy Persons

NCT ID: NCT00801034

Last Updated: 2015-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-11-30

Study Completion Date

2011-11-30

Brief Summary

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In humans living of fruit and vegetables, hypertension is rarely seen. We wish to study if the development of hypertension has a connection to our intake of potassium. We know that fruit and vegetables contain a lot of potassium and we will simulate this intake by giving healthy subjects potassium as tablets.

Detailed Description

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Conditions

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Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Calcium tablets

Group Type PLACEBO_COMPARATOR

Calcium

Intervention Type DRUG

tablets, 1 tablet 2 times per day in 28 days

2

Potassium tablets

Group Type ACTIVE_COMPARATOR

Potassium

Intervention Type DRUG

Tablets, 5 tablets 2 times per day for 28 days

Interventions

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Calcium

tablets, 1 tablet 2 times per day in 28 days

Intervention Type DRUG

Potassium

Tablets, 5 tablets 2 times per day for 28 days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* healthy
* age 18-40 years old
* BMI 18, 5-30
* non-smoker

Exclusion Criteria

* daily use of medicine
* alcohol or drugs
* desire to become pregnant
* not using safe anti-contraceptive
* abnormal results in the initial testing
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Erling Bjerregaard Pedersen

OTHER

Sponsor Role lead

Responsible Party

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Erling Bjerregaard Pedersen

professor, chief physician

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Department of medical research

Holstebro, Holstebro, Denmark

Site Status

Countries

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Denmark

References

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Matthesen SK, Larsen T, Vase H, Lauridsen TG, Pedersen EB. Effect of potassium supplementation on renal tubular function, ambulatory blood pressure and pulse wave velocity in healthy humans. Scand J Clin Lab Invest. 2012 Feb;72(1):78-86. doi: 10.3109/00365513.2011.635216. Epub 2011 Dec 12.

Reference Type DERIVED
PMID: 22149452 (View on PubMed)

Other Identifiers

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MED.RES.HOS.2008.01.SKM

Identifier Type: -

Identifier Source: org_study_id

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