Effects of Chronic Smoking on Circulating Endothelial and Platelet-derived Microparticle

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-11-30

Study Completion Date

2010-11-30

Brief Summary

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The investigators hypothesized that circulating EMP is a useful surrogate marker of early stage of endothelial damage. To determine the effects of chronic smoking on circulating EMP, from healthy volunteers who have habit of chronic smoking, peripheral blood is drawn at the time of flow-mediated dilatation (FMD) examination. Spot urine is also collected. Circulating EMPs are counted using flow-cytometry. After 2-week smoking cessation, the measurements were repeated.

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Detailed Description

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Conditions

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Atherosclerosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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smoker

Individuals who have a habit of chronic smoking without any coronary risk factors

Group Type EXPERIMENTAL

smoking cessation

Intervention Type BEHAVIORAL

After baseline examination, the group is asked to quit smoking for 2 weeks.

non-smoker

the age-matched healthy volunteers

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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smoking cessation

After baseline examination, the group is asked to quit smoking for 2 weeks.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* healthy individuals who have no coronary risk factors

Exclusion Criteria

* hypertension
* dyslipidemia
* chronic kidney disease
* liver dysfunction
* obesity (BMI\>25.0)
* cerebrovascular disease
* other severe systemic diseases (cancer, inflammatory diseases, etc)

Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes