Comparison of Electrodessication, Potassium Titanyl Phosphate (KTP) Laser and Pulsed Dye Laser for Treatment of Cherry Angiomata

NCT ID: NCT00791908

Last Updated: 2015-03-06

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2006-09-30
• Study Completion Date: 2007-10-31

Brief Summary

The primary objective of this study is to determine whether laser treatments over 6 weeks using the pulsed dye laser system or the potassium titanyl phosphate (KTP) laser are effective in patients with cherry angiomas as observed by a physician provider and the subject.

The investigators hypothesize that the two laser treatments will be an effective tool for treating cherry angiomas. The investigators aim to compare these modalities to electrodessication, as all three modalities are considered the current standard of care. Electrodessication can result in atrophic lesions at the site of the treated cherry angiomas.

In summary, the goal of this project is to compare the non-ablative pulsed dye laser and the AuraTM potassium titanyl phosphate (KTP) laser to each other and to the current standard of care, electrodessication.

Conditions

Cherry Angioma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

electrodessication (ED)

Treatment over 6 weeks using electrodessication (ED) to remove cherry angiomas. Each participant received treatment with PDL, KTP laser, and electrodesiccation to separate randomly selected areas on the torso, with each area bearing 4 cherry angiomata.

Group Type: EXPERIMENTAL

Electrodessication

Intervention Type: PROCEDURE

Treatment applied to a third of the torso at each study visit.

pulsed dye laser (PDL)

Treatment over 6 weeks using pulsed dye laser (PDL) to remove cherry angiomas. Each participant received treatment with PDL, KTP laser, and electrodesiccation to separate randomly selected areas on the torso, with each area bearing 4 cherry angiomata.

Group Type: EXPERIMENTAL

Pulsed dye laser (PDL)

Intervention Type: PROCEDURE

Laser treatment applied to a third of the torso at each study visit.

potassium titanyl phosphate (KTP) laser

Treatment over 6 weeks using potassium titanyl phosphate (KTP) laser to remove cherry angiomas. Each participant received treatment with PDL, KTP laser, and electrodesiccation to separate randomly selected areas on the torso, with each area bearing 4 cherry angiomata.

Group Type: EXPERIMENTAL

potassium titanyl phosphate (KTP)

Intervention Type: PROCEDURE

Laser treatment applied to a third of the torso at each study visit.

Interventions

Electrodessication

Treatment applied to a third of the torso at each study visit.

Intervention Type: PROCEDURE

Pulsed dye laser (PDL)

Laser treatment applied to a third of the torso at each study visit.

Intervention Type: PROCEDURE

potassium titanyl phosphate (KTP)

Laser treatment applied to a third of the torso at each study visit.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Age 18 to 95 years.
• Have at least 12 cherry angiomas (4 per each third of the torso) that have been documented.
• The subjects are in medically stable condition.
• The subject has willingness and the ability to understand and provide informed consent for the procedure and is able to communicate with the investigator.
• Must be willing not to employ other treatment options for cherry angiomas during the course of this study.

Exclusion Criteria

• Under 18 years of age and over 95 years of age
• Pregnancy or lactation.
• Subjects who are unable to understand the protocol or to give informed consent.
• Subjects cannot have had previous laser treatment in the last 6 months before enrollment.
• Subjects have a cardiac defibrillator or pacemakers that may interact with the electrodesiccation technique.
• Subjects have no serious medical conditions that would contradict participation in the research.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 95 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Northwestern University

OTHER

Sponsor Role: lead

Responsible Party

Northwestern University

Principal Investigators

Murad Alam, MD

Role: PRINCIPAL_INVESTIGATOR

Northwestern University

Locations

Northwestern University

Chicago, Illinois, United States

Countries

United States

References

Collyer J, Boone SL, White LE, Rademaker A, West DP, Anderson K, Kim NA, Smith S, Yoo S, Alam M. Comparison of treatment of cherry angiomata with pulsed-dye laser, potassium titanyl phosphate laser, and electrodesiccation: a randomized controlled trial. Arch Dermatol. 2010 Jan;146(1):33-7. doi: 10.1001/archdermatol.2009.318.

Reference Type: RESULT

PMID: 20083690 (View on PubMed)

Other Identifiers

MA-STU81

Identifier Type: -

Identifier Source: org_study_id