A Study to Assess the Safety and Tolerability of ASP1941 in Adults With Type 2 Diabetes Mellitus.

NCT ID: NCT00790660

Last Updated: 2024-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

61 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-10-23

Study Completion Date

2009-03-06

Brief Summary

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This study is intended to assess safety and tolerability of ASP1941 compared to placebo in adult subjects with type 2 diabetes mellitus

Detailed Description

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Trial includes a two week washout period before entering the treatment period for subjects on oral anti-diabetic medication.

Conditions

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Diabetes Mellitus, Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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ASP1941 Lowest Dose

Oral

Group Type EXPERIMENTAL

ASP1941

Intervention Type DRUG

Oral

ASP1941 Low Dose

Oral

Group Type EXPERIMENTAL

ASP1941

Intervention Type DRUG

Oral

ASP1941 Medium Dose

Oral

Group Type EXPERIMENTAL

ASP1941

Intervention Type DRUG

Oral

ASP1941 High Dose

Oral

Group Type EXPERIMENTAL

ASP1941

Intervention Type DRUG

Oral

Placebo

Oral

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Oral

Interventions

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ASP1941

Oral

Intervention Type DRUG

Placebo

Oral

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Established diagnosis of type 2 diabetes mellitus
* HbA1c value between 7.0 and 10.0%
* Body mass index between 20 and 45 kg/m2

Exclusion Criteria

* Established diagnosis of type 1 diabetes mellitus
* Serum creatinine \> upper limit of normal range
* Proteinuria (microalbumin/creatinine ratio \> 300 mg/g)
* Urinary tract infection
* Severe uncontrolled Hypertension
* Significant renal, hepatic or cardiovascular disease
* HIV Positive
* History of drug or alcohol abuse/dependency
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Astellas Pharma Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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use Central Contact

Role: STUDY_DIRECTOR

Astellas Pharma Global Development

Locations

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San Antonio, Texas, United States

Site Status

Countries

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United States

Related Links

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https://astellasclinicalstudyresults.com/study.aspx?ID=3

Link to results on the Astellas Clinical Study Results website.

Other Identifiers

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1941-CL-0016

Identifier Type: -

Identifier Source: org_study_id

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