Diaphragmatic Function in Ventilated Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

55 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-03-31

Study Completion Date

2010-07-31

Brief Summary

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Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called ventilator-induced diaphragmatic dysfunction (VIDD).

Detailed Description

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Conditions

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Critically Ill

Keywords

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Mechanical ventilation Ventilator induced diaphragmatic dysfunction Weaning Neuromuscular diseases- Respiratory function tests Intubated patients in intensive care unit

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Invasive mechanical ventilation (tracheally intubated or tracheotomized) less than 48h.·
* Duration of mechanical ventilation for at least 72h.·
* Subject itself or its next of kin has given written informed consent

Exclusion Criteria

* Patient is less than 18 years or more than 85 years of age·
* The attending physician refuses to allow enrollment·
* The patient refuses informed consent
* Next of kin is unavailable or refuses informed consent·
* Pregnant or breast-feeding female.
* A pregnancy test will be performed in all female patients less than 60 years of age.·
* Any contraindication to use cervical magnetic stimulation (mechanical cardiac assist device …).·
* Presence or suspicion of prior diaphragm injury or chronic disease·
* Presence or suspicion of a central nervous system (CNS) disorder, including (but not limited to): CNS infarction, bleeding, tumor, or infection

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Thomas SIMILOWSKI, MD, PhD

Role: STUDY_CHAIR

Groupe Hospitalier La Pitié-Salpêtrière-Paris

Locations

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Department of Anesthesia and Critical Care (DAR B)

Saint-Eloi University Hospital of Montpellier, Montpellier, France

Site Status

Service de Pneumologie et Réanimation

Groupe Hospitalier La Pitié-Salpêtrière-Paris, Paris, France

Site Status

Countries

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France

References

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Demoule A, Molinari N, Jung B, Prodanovic H, Chanques G, Matecki S, Mayaux J, Similowski T, Jaber S. Patterns of diaphragm function in critically ill patients receiving prolonged mechanical ventilation: a prospective longitudinal study. Ann Intensive Care. 2016 Dec;6(1):75. doi: 10.1186/s13613-016-0179-8. Epub 2016 Aug 5.

Reference Type DERIVED

PMID: 27492005 (View on PubMed)

Demoule A, Jung B, Prodanovic H, Molinari N, Chanques G, Coirault C, Matecki S, Duguet A, Similowski T, Jaber S. Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study. Am J Respir Crit Care Med. 2013 Jul 15;188(2):213-9. doi: 10.1164/rccm.201209-1668OC.