Effect of Commercial Rye Whole-Meal Bread on Postprandial Blood Glucose and Gastric Emptying in Healthy Subjects

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Study Classification

OBSERVATIONAL

Brief Summary

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Increased intake of dietary fibre and whole grains is related to reduced risk of developing diabetes. The term "whole grain" is often used for whole-meal products in which the structure of the cereal grain is destroyed in the flour containing the original dietary fiber, but also for cereal products in which a large proportion of whole cereal grains is intact. The aim of this study was to evaluate the effect of commercial rye whole-meal bread (RWMB) compared to white-wheat bread (WWB) on gastric emptying rate (GER), postprandial glucose response in healthy subjects.

Detailed Description

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Ten healthy subjects, without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus, were assessed by using a blinded crossover trial. The subjects were examined regarding blood glucose levels and GER after ingestion of 150g WWB or RWMB on two different occasions after an overnight fast. GER was measured using a standardized real time ultrasonography. GER was calculated as a percentage change in antral cross sectional area 15 and 90 minutes after the finished meal with WWB and RWMB. Finger-prick capillary samples were collected before and 40, 60, and 90 min after the start of the meal to measure blood glucose levels.

Conditions

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Healthy

Keywords

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rye whole-meal bread white-wheat bread gastric emptying rate postprandial glucose response healthy subjects

Study Groups

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Healthy subjects

Healthy subjects, without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

Exclusion Criteria

* with symptoms or prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Locations

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Dept. of Medicine, Malmö University Hospital,

Malmo, Skåne County, Sweden

Site Status

Countries

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Sweden

References

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Hlebowicz J, Jonsson JM, Lindstedt S, Bjorgell O, Darwich G, Almer LO. Effect of commercial rye whole-meal bread on postprandial blood glucose and gastric emptying in healthy subjects. Nutr J. 2009 Jun 16;8:26. doi: 10.1186/1475-2891-8-26.

Reference Type DERIVED

PMID: 19531257 (View on PubMed)

Other Identifiers

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Dnr 709/2004

Identifier Type: -

Identifier Source: org_study_id