Effect of Commercial Rye Whole-Meal Bread on Postprandial Blood Glucose and Gastric Emptying in Healthy Subjects

NCT ID: NCT00779298

Last Updated: 2008-10-24

Basic Information

• Recruitment Status: COMPLETED
• Study Classification: OBSERVATIONAL

Brief Summary

Increased intake of dietary fibre and whole grains is related to reduced risk of developing diabetes. The term "whole grain" is often used for whole-meal products in which the structure of the cereal grain is destroyed in the flour containing the original dietary fiber, but also for cereal products in which a large proportion of whole cereal grains is intact. The aim of this study was to evaluate the effect of commercial rye whole-meal bread (RWMB) compared to white-wheat bread (WWB) on gastric emptying rate (GER), postprandial glucose response in healthy subjects.

Detailed Description

Ten healthy subjects, without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus, were assessed by using a blinded crossover trial. The subjects were examined regarding blood glucose levels and GER after ingestion of 150g WWB or RWMB on two different occasions after an overnight fast. GER was measured using a standardized real time ultrasonography. GER was calculated as a percentage change in antral cross sectional area 15 and 90 minutes after the finished meal with WWB and RWMB. Finger-prick capillary samples were collected before and 40, 60, and 90 min after the start of the meal to measure blood glucose levels.

Conditions

Healthy

Study Groups

Healthy subjects

Healthy subjects, without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

Exclusion Criteria

• with symptoms or prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Lund University Hospital

OTHER

Sponsor Role: lead

Locations

Dept. of Medicine, Malmö University Hospital,

Malmo, Skåne County, Sweden

Countries

Sweden

References

Hlebowicz J, Jonsson JM, Lindstedt S, Bjorgell O, Darwich G, Almer LO. Effect of commercial rye whole-meal bread on postprandial blood glucose and gastric emptying in healthy subjects. Nutr J. 2009 Jun 16;8:26. doi: 10.1186/1475-2891-8-26.

Reference Type: DERIVED

PMID: 19531257 (View on PubMed)

Other Identifiers

Dnr 709/2004

Identifier Type: -

Identifier Source: org_study_id