Improving Glycogen Liver Content Will Improve Post-operative Liver Function in Patients Undergoing Major Liver Resections
NCT ID: NCT00774098
Last Updated: 2010-04-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
60 participants
INTERVENTIONAL
2007-01-31
2009-09-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effect of Preoperative Carbohydrate Loading on Post-operative Insulin Resistance After Donor Hepatectomy.
NCT05293444
Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining Normoglycemia
NCT02032953
Interest of PReOPerative Immunonutrition in Liver Surgery for Cancer
NCT02041871
Pre-operative Carbohydrates in Diabetic Patients Undergoing CABG
NCT05540249
Carbohydrates and Proteins 3h Before Surgery
NCT01563965
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Control Group
Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output
Intravenous normal saline (NS 0.9)
Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output
GICP
dextrose 10% (D10W ®) infusion
Started at 8pm the day before surgery until the procedure begins
hyperinsulinemic normoglycemic clamp
Started as the procedure begins, decreased at the end of the procedure and continued until 16 hours postoperatively
high calorie diet 35 kcal/kg
High Calorie meals start the day before the surgery and are given 5 hours apart. The last meal is given at 7 pm the day before surgery
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
dextrose 10% (D10W ®) infusion
Started at 8pm the day before surgery until the procedure begins
hyperinsulinemic normoglycemic clamp
Started as the procedure begins, decreased at the end of the procedure and continued until 16 hours postoperatively
high calorie diet 35 kcal/kg
High Calorie meals start the day before the surgery and are given 5 hours apart. The last meal is given at 7 pm the day before surgery
Intravenous normal saline (NS 0.9)
Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* planned to undergo a major liver resection at McGill University Health Center (MUHC)
Exclusion Criteria
* uncontrolled or type one diabetes mellitus (DM)
* patients on oral beta-blocker agents
* patients with unresectable disease determined intra-operatively
* patients unable to give consent for the study.
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
McGill University Health Centre/Research Institute of the McGill University Health Centre
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
MUHC
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Royal Victoria Hospital
Montreal, Quebec, Canada
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Hassanain M, Metrakos P, Fisette A, Doi SA, Schricker T, Lattermann R, Carvalho G, Wykes L, Molla H, Cianflone K. Randomized clinical trial of the impact of insulin therapy on liver function in patients undergoing major liver resection. Br J Surg. 2013 Apr;100(5):610-8. doi: 10.1002/bjs.9034. Epub 2013 Jan 21.
Fisette A, Hassanain M, Metrakos P, Doi SA, Salman A, Schricker T, Lattermann R, Wykes L, Nitschmann E, Smith J, Cianflone K. High-dose insulin therapy reduces postoperative liver dysfunction and complications in liver resection patients through reduced apoptosis and altered inflammation. J Clin Endocrinol Metab. 2012 Jan;97(1):217-26. doi: 10.1210/jc.2011-1598. Epub 2011 Oct 26.
Sato H, Lattermann R, Carvalho G, Sato T, Metrakos P, Hassanain M, Matsukawa T, Schricker T. Perioperative glucose and insulin administration while maintaining normoglycemia (GIN therapy) in patients undergoing major liver resection. Anesth Analg. 2010 Jun 1;110(6):1711-8. doi: 10.1213/ANE.0b013e3181d90087. Epub 2010 Apr 7.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
SDR-06-012
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.