Ivermectin Versus Albendazole for Chronic Strongyloidiasis

NCT ID: NCT00765024

Last Updated: 2017-09-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-07-31

Study Completion Date

2010-04-30

Brief Summary

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A prospective controlled trial to compare the efficacy and safety of 7-day albendazole, single dose ivermectin, and 2-single dose ivermectin in 72 patients with chronic strongyloidiasis will be conducted at Siriraj Hospital, Bangkok, Thailand.

Detailed Description

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Conditions

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Chronic Strongyloidiasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Albendazole

Albendazole for 7 days

Group Type ACTIVE_COMPARATOR

Albendazole

Intervention Type DRUG

Albendazole 7 days

ivermectin

ivermectin 200 mcg/kg single dose

Group Type EXPERIMENTAL

Ivermectin

Intervention Type DRUG

single dose of 200 mcg/kg

ivermectin 2 doses

ivermectin 200 mcg/kg two doses in 2 weeks

Group Type EXPERIMENTAL

ivermectin

Intervention Type DRUG

two single dose of 200mcg/kg in 2 weeks

Interventions

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Ivermectin

single dose of 200 mcg/kg

Intervention Type DRUG

ivermectin

two single dose of 200mcg/kg in 2 weeks

Intervention Type DRUG

Albendazole

Albendazole 7 days

Intervention Type DRUG

Other Intervention Names

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stromectal stromectal

Eligibility Criteria

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Inclusion Criteria

* Patients with positive strongyloides larva in the stool

Exclusion Criteria

* Pregnancy
* Lactating women
* Known allergy to any study drug
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Atlantic Laboratory Ltd

UNKNOWN

Sponsor Role collaborator

Mahidol University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yupin Suputtamongkol, MD

Role: PRINCIPAL_INVESTIGATOR

Mahidol University

Locations

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Siriraj Hospital

Bangkoknoi, Bangkok, Thailand

Site Status

Countries

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Thailand

References

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Suputtamongkol Y, Premasathian N, Bhumimuang K, Waywa D, Nilganuwong S, Karuphong E, Anekthananon T, Wanachiwanawin D, Silpasakorn S. Efficacy and safety of single and double doses of ivermectin versus 7-day high dose albendazole for chronic strongyloidiasis. PLoS Negl Trop Dis. 2011 May 10;5(5):e1044. doi: 10.1371/journal.pntd.0001044.

Reference Type DERIVED
PMID: 21572981 (View on PubMed)

Other Identifiers

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TM001-2008

Identifier Type: -

Identifier Source: org_study_id

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