Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

10157 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-05-13

Study Completion Date

2032-12-31

Brief Summary

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The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.

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Detailed Description

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Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.

Conditions

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Community Based Study Cardiovascular Disease Sudden Death Blood Pressure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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general population

Observational study of 10157 adult men and women from the general population who benefited from a free extensive health check up in Paris, France

Spider flash ECG, high-precision carotid echo-tracking, step test

Intervention Type OTHER

cardiac rhythm recorded during health check up, vascular aging parameters and baroreflex sensitivity recorded during carotid echotracking of the right common carotid artery , step test during 2 minutes

Interventions

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Spider flash ECG, high-precision carotid echo-tracking, step test

cardiac rhythm recorded during health check up, vascular aging parameters and baroreflex sensitivity recorded during carotid echotracking of the right common carotid artery , step test during 2 minutes

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 50-75 years, French speaking, given consent for genetic analysis,
* written consent for participating in the study

Exclusion Criteria

* \<50 years and \>75 years,
* no French speaking,
* current pregnancy,
* chronic severe disease,
* disagreement for genetic analysis,
* step test considered as non possible or non advisable by medical decision.

Minimum Eligible Age

50 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes