The Use of Continuous Wound Infusion Analgesia in Total Knee Arthroplasty

NCT ID: NCT00724074

Last Updated: 2008-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Brief Summary

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The main purpose of this study is to determine if there is improvement in pain and other patient outcomes when using a continuous wound analgesia system after total knee replacement, compared to usual methods of pain control. Another purpose is to determine if the system makes it easier for nurses to care for these patients.

Detailed Description

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Continuous local wound infusion analgesia is a relatively new way of managing post-operative pain, whereby a local anesthetic is continuously infused into the surgical area. Some studies and users have reported decreased pain, decreased opioid use, decreased post-operative nausea and vomiting, decreased length of stay, and improved patient and caregiver satisfaction with the use of continuous local wound infusion analgesia, when compared to placebo, or usual care, in arthroplasty and other surgical interventions.

Hypotheses:

Primary:

The On-Q PainBuster (continuous wound infusion analgesia) in TKA will result in improved patient pain control, compared to usual care.

Secondary:

* Pain scores post-operatively will be better than usual care.
* Fewer narcotics will be ingested post-operatively than with usual care.
* Post-op nausea and vomiting will be less than usual care.
* Length of stay will be shorter compared to usual care.
* Patient satisfaction will be greater than satisfaction with usual care.
* Post-operative infection rates will be no different between groups.
* Fall rates will be no different between groups.
* Subjects will participate in physical therapy the day of surgery.
* Nursing Intensity requirements will be less with the wound infusion due to fewer requests for pain medication.

Conditions

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Total Knee Arthroplasty

Keywords

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Arthritis of the knee Knee replacement Osteoarthritis, knee Arthroplasty, knee

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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S

Patients receive the On-Q local continuous wound infusion system intra-operatively and use it for up to three days post-operatively.

Group Type EXPERIMENTAL

On-Q PainBuster with Bupivacaine

Intervention Type DEVICE

On-Q PainBuster continuous wound infusion analgesia system, using bupivacaine as the local anaesthetic

C

Usual care - post operative pain medications as per the knee arthroplasty care map.

Group Type ACTIVE_COMPARATOR

Usual Care

Intervention Type DEVICE

Usual Care

Interventions

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On-Q PainBuster with Bupivacaine

On-Q PainBuster continuous wound infusion analgesia system, using bupivacaine as the local anaesthetic

Intervention Type DEVICE

Usual Care

Usual Care

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Scheduled for TKA at the Royal Alexandra Hospital
* Patient of Dr. Arnett
* Deemed fit for continuous wound infusion (no allergies to Bupivacaine or related medications) by anesthesia
* Cognitively aware, and provides informed consent
* Elective (not trauma-related) surgery
* Able to read, speak and understand English
* Adult \< 70 years of age
* Intra-operative spinal anaesthesia
* Reside within metropolitan Edmonton, in a bungalow
* Have a caregiver at home
* ASA risk classification of 1 or 2
* Do not regularly use opioid medication pre-operatively
* Have preoperative knee range of motion \> 90 degrees
* Body Mass Index \< 40
* No known hepatic or liver insufficiency

Exclusion Criteria

* Deemed unfit for continuous wound infusion due to allergies
Minimum Eligible Age

18 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Capital Health, Canada

OTHER

Sponsor Role lead

Responsible Party

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Capital Health

Principal Investigators

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Gordon Arnett, MD

Role: PRINCIPAL_INVESTIGATOR

Capital Health, Canada

Locations

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Royal Alexandra Hospital

Edmonton, Alberta, Canada

Site Status

Countries

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Canada

Central Contacts

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Holly Meyer, MSc

Role: CONTACT

Phone: 780-735-1119

Email: [email protected]

Gordon Arnett, MD

Role: CONTACT

Phone: 780-455-5115

Email: [email protected]

Other Identifiers

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garnett

Identifier Type: -

Identifier Source: org_study_id